INT97878

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.73
Pain Relevance 4.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pias1) enzyme binding (Pias1) DNA binding (Pias1)
ligase activity (Pias1)
Anatomy Link Frequency
plasma 1
brain 1
Pias1 (Mus musculus)
Pain Link Frequency Relevance Heat
Gabapentin 50 100.00 Very High Very High Very High
anticonvulsant 2 96.80 Very High Very High Very High
Inflammation 88 96.56 Very High Very High Very High
Neuropathic pain 2 92.88 High High
cerebral cortex 1 91.08 High High
antagonist 2 83.60 Quite High
carbamazepine 1 68.96 Quite High
antiepileptic Drug 1 67.48 Quite High
agonist 17 63.60 Quite High
cytokine 37 57.64 Quite High
Disease Link Frequency Relevance Heat
Convulsion 6 98.84 Very High Very High Very High
Cognitive Disorder 4 97.52 Very High Very High Very High
INFLAMMATION 105 96.56 Very High Very High Very High
Syndrome 2 93.28 High High
Neuropathic Pain 2 92.88 High High
Neurodegenerative Disease 2 87.04 High High
Disease 14 83.76 Quite High
Targeted Disruption 13 82.00 Quite High
Epilepsy 1 75.00 Quite High
Cardiovascular Disease 18 51.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is evidence, however, that the neuroprotective properties attributed to GBP are rather associated with a derivative of GBP, gabapentin-lactam (GBP-L), which opens mitochondrial ATP-dependent K+ channels, in contrast to GBP.
Positive_regulation (derivative) of GBP associated with gabapentin
1) Confidence 0.50 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15322735 Disease Relevance 0.58 Pain Relevance 1.41
There is evidence, however, that the neuroprotective properties attributed to GBP are rather associated with a derivative of GBP, gabapentin-lactam (GBP-L), which opens mitochondrial ATP-dependent K+ channels, in contrast to GBP.
Positive_regulation (derivative) of GBP-L associated with gabapentin
2) Confidence 0.50 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15322735 Disease Relevance 0.59 Pain Relevance 1.43
These results suggest that maintenance of stable GBP plasma levels could protect against seizures without causing memory impairment.
Positive_regulation (maintenance) of GBP in plasma associated with cognitive disorder, convulsion and gabapentin
3) Confidence 0.41 Published 2010 Journal Epilepsy Behav Section Abstract Doc Link 20079694 Disease Relevance 0.45 Pain Relevance 0.82
AEDs either increased (PHT and GBP) or decreased (SVP) brain histamine content in different regions to varying degrees.
Positive_regulation (increased) of GBP in brain associated with gabapentin
4) Confidence 0.26 Published 2001 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11526971 Disease Relevance 0.40 Pain Relevance 0.63
interacts with the protein inhibitor of the activated transcription factor, STAT-1 (PIAS1).
Positive_regulation (activated) of PIAS1
5) Confidence 0.24 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.23 Pain Relevance 0.14
associates with the protein inhibitor of activated STAT1 (PIAS1), which is a small ubiquitin-like modifier (SUMO)-E3 ligase, in a ligand-dependent manner.
Positive_regulation (activated) of PIAS1
6) Confidence 0.18 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 0.48 Pain Relevance 0.21

General Comments

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