INT97891

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2001
Last Reported 2011
Negated 5
Speculated 2
Reported most in Body
Documents 108
Total Number 113
Disease Relevance 24.85
Pain Relevance 9.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl) extracellular region (Ghrl) cytoplasm (Ghrl)
Anatomy Link Frequency
neurons 10
brain 6
tongue 5
taste buds 4
stomach 3
Ghrl (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor antagonist 12 100.00 Very High Very High Very High
Ventral tegmentum 308 99.98 Very High Very High Very High
Calcium channel 143 99.40 Very High Very High Very High
Somatostatin 333 99.28 Very High Very High Very High
GABAergic 99 98.86 Very High Very High Very High
Endocannabinoid 175 98.72 Very High Very High Very High
antagonist 1092 98.68 Very High Very High Very High
Dopamine 300 98.48 Very High Very High Very High
tolerance 825 98.16 Very High Very High Very High
Glutamate 81 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 2661 100.00 Very High Very High Very High
Insulin Resistance 815 100.00 Very High Very High Very High
Obesity 2483 99.84 Very High Very High Very High
Salivary Gland Disease 72 99.60 Very High Very High Very High
Syndrome 369 99.08 Very High Very High Very High
Impaired Glucose Tolerance 904 98.48 Very High Very High Very High
Stress 69 98.24 Very High Very High Very High
Starvation 53 97.40 Very High Very High Very High
Diabetes Mellitus 1352 96.32 Very High Very High Very High
Hyperphagia 152 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ghrelin is expressed in trigeminal neurons of female mice in phase with the estrous cycle.
Gene_expression (expressed) of Ghrelin in neurons
1) Confidence 0.77 Published 2006 Journal Neuropeptides Section Title Doc Link 16376425 Disease Relevance 0.19 Pain Relevance 0.34
In addition, they were observed to have lower serum leptin and elevated ghrelin levels, where leptin is known to act as an appetite suppressant, whereas ghrelin seems to stimulate hunger.25
Gene_expression (levels) of ghrelin
2) Confidence 0.65 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 0.66 Pain Relevance 0
Ghrelin was present in trigeminal neurons containing peripherin, a marker of neurons with unmyelinated axons, in trigeminal neurons binding IB4, a marker of nonpeptidergic nociceptors, in trigeminal neurons containing neurofilament H, a marker of neurons with myelinated axons, and in trigeminal neurons containing the neuropeptide calcitonin gene-related peptide (CGRP).
Gene_expression (present) of Ghrelin in neurons associated with nociceptor, neuropeptide, unmyelinated and calcitonin gene-related peptide
3) Confidence 0.60 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16376425 Disease Relevance 0.12 Pain Relevance 0.51
Prepro-ghrelin, prohormone convertase 1/3 (PC 1/3), ghrelin, its cognate receptor (GHSR), and ghrelin-O-acyltransferase (GOAT , the enzyme that activates ghrelin) are expressed in Type I, II, III and IV taste cells of mouse taste buds.
Gene_expression (expressed) of ghrelin in taste buds
4) Confidence 0.57 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2939079 Disease Relevance 0 Pain Relevance 0
Ghrelin has also been shown to be produced by human salivary glands and is secreted into saliva [23].
Gene_expression (produced) of Ghrelin in saliva associated with salivary gland disease
5) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.10 Pain Relevance 0
This observation could explain why the GHSR null mice only showed alterations in taste sensitivity to salty and sour tastants, even though ghrelin and GHSR were expressed in all 4 cell types.
Gene_expression (expressed) of ghrelin
6) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0 Pain Relevance 0.03
We found that ghrelin and GHSR are expressed in the fungiform papillae (Figures S5A and S5B).
Gene_expression (re expres) of ghrelin in papillae
7) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0 Pain Relevance 0.06
Prepro-ghrelin, prohormone convertase 1/3 (PC 1/3), ghrelin, its cognate receptor (GHSR), and ghrelin-O-acyltransferase (GOAT , the enzyme that activates ghrelin) are expressed in Type I, II, III and IV taste cells of mouse taste buds.
Gene_expression (expressed) of ghrelin in taste buds
8) Confidence 0.57 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2939079 Disease Relevance 0 Pain Relevance 0
Future studies are needed that may definitely demonstrate that ghrelin (and other additional hormones expressed in TCs) is released from TCs.
Gene_expression (expressed) of ghrelin
9) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.07 Pain Relevance 0.08
The majority of cells that contained the GHSR also expressed ghrelin (Figure 5A–C).
Gene_expression (expressed) of ghrelin
10) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.06 Pain Relevance 0.04
Firstly, TCs express both ghrelin and its receptor.
Gene_expression (express) of ghrelin
11) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.07 Pain Relevance 0.29
Secondly, in the GHSR null mice we demonstrated a hyposensitivity to only CA (sour) and NaCl (salty) tastes, indicating that—despite ghrelin and GHSR being expressed in all four TC types—there was not a widespread effect on all taste qualities.
Gene_expression (expressed) of ghrelin
12) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.06 Pain Relevance 0.26
Ghrelin expression is not limited to the stomach, but is found at many other sites such as the small intestine, brain, pituitary, lung, skeletal muscle, islets of Langerhans, adrenal glands, ovary, and testis [22].
Gene_expression (expression) of Ghrelin in islets of Langerhans
13) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.08 Pain Relevance 0
The cloned receptor for ghrelin (GHS-R1A) is present, however, not only in discrete hypothalamic cell groups regulating energy balance but also in a number of other central nervous system (CNS) sites, such as the hippocampus, brainstem and reinforcement areas (Guan et al. 1997) implying a role for ghrelin in brain reinforcement.
Gene_expression (present) of ghrelin in cell groups associated with medulla, hippocampus and central nervous system
14) Confidence 0.52 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0.09 Pain Relevance 0.35
In this study, we examined expression of the orexigenic peptide ghrelin in trigeminal ganglia of cycling female mice.
Spec (examined) Gene_expression (expression) of ghrelin in trigeminal ganglia
15) Confidence 0.52 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16376425 Disease Relevance 0.16 Pain Relevance 0.38
Prepro-ghrelin, prohormone convertase 1/3 (PC 1/3), ghrelin, its cognate receptor (GHSR), and ghrelin-O-acyltransferase (GOAT , the enzyme that activates ghrelin) are expressed in Type I, II, III and IV taste cells of mouse taste buds.
Gene_expression (expressed) of ghrelin in taste buds
16) Confidence 0.50 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2939079 Disease Relevance 0 Pain Relevance 0
We found that 4% of total taste cells were GOAT immunopositive, 13% of total taste cells were ghrelin immunopositive, and both GOAT and ghrelin were co-expressed in 4% of taste cells.
Gene_expression (expressed) of ghrelin
17) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.06 Pain Relevance 0.03
We found that 4% of total taste cells were GOAT immunopositive, 13% of total taste cells were ghrelin immunopositive, and both GOAT and ghrelin were co-expressed in 4% of taste cells.
Gene_expression (expressed) of ghrelin
18) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0 Pain Relevance 0
In addition, ghrelin and GHSR co-localize in the same taste cells, suggesting that ghrelin works in an autocrine manner in taste cells.
Gene_expression (works) of ghrelin
19) Confidence 0.50 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2939079 Disease Relevance 0 Pain Relevance 0
Alternately, the different hypothalamic effects of ghrelin might evolve independently during development, since ghrelin and GHSR are expressed at early stages in life [34], [35], [63].
Gene_expression (expressed) of ghrelin
20) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox