INT97894

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 11.82
Pain Relevance 4.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
hypothalamus 6
brain 4
visceral 2
tail 2
striatum 2
Crh (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 43 100.00 Very High Very High Very High
cytokine 147 99.98 Very High Very High Very High
Eae 32 99.84 Very High Very High Very High
amygdala 141 99.36 Very High Very High Very High
Dynorphin 49 99.22 Very High Very High Very High
depression 128 99.20 Very High Very High Very High
Neuropeptide 114 98.80 Very High Very High Very High
Catecholamine 10 98.56 Very High Very High Very High
Kinase C 134 96.96 Very High Very High Very High
Glutamate receptor 4 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 582 100.00 Very High Very High Very High
Targeted Disruption 217 99.98 Very High Very High Very High
Nociception 3 99.90 Very High Very High Very High
Anxiety Disorder 169 99.84 Very High Very High Very High
Depression 146 99.20 Very High Very High Very High
Disease 27 97.44 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 3 97.32 Very High Very High Very High
Convulsion 20 92.84 High High
Starvation 93 92.20 High High
Cystitis 3 89.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that visceral nociception may upregulate both galanin and CRH gene expression in the hypothalamic and limbic nuclei.
Spec (may) Positive_regulation (upregulate) of Gene_expression (expression) of CRH gene in visceral associated with nociception
1) Confidence 0.70 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17335920 Disease Relevance 0.52 Pain Relevance 0.59
The activation of the PKA signaling also increases the CRH gene expression in rat fetal hypothalamic cultures (Emanuel et al. 1992), or primary amygdalar cultures (Kasckow et al. 1997).
Positive_regulation (increases) of Gene_expression (expression) of CRH gene
2) Confidence 0.57 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.11 Pain Relevance 0
Adrenalectomy induces the CRH mRNA expression in the PVN; however, the CRH gene expression was decreased by glucocorticoid replacement (Jingami et al. 1985; Bayer et al. 1988).
Positive_regulation (induces) of Gene_expression (expression) of CRH mRNA
3) Confidence 0.57 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.22 Pain Relevance 0
The latter interesting observation suggests that a physiological concentration of glucocorticoid is important for the stress-induced CRH expression.
Positive_regulation (important) of Gene_expression (expression) of CRH associated with stress
4) Confidence 0.57 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.25 Pain Relevance 0.06
The vasopressin and CRH gene expression is activated by numerous physiological stimuli, as described above.
Positive_regulation (activated) of Gene_expression (expression) of CRH gene
5) Confidence 0.57 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.49 Pain Relevance 0.17
TPA stimulates the CRH gene expression in heterologous NPLC cells through the elongation of the additional poly (A) tail (Adler et al. 1992).
Positive_regulation (stimulates) of Gene_expression (expression) of CRH gene in tail
6) Confidence 0.57 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.09 Pain Relevance 0.26
Microarray results indicated the inhibitory effects of corticotropin-releasing factor (CRF) receptor 1 (CRFR1) and GR antagonists (antalarmin and RU486, respectively, blocked 65% of ethanol activation, P < 0.05) on gene expression activation of the B3 subcluster (Figure 4f, g).
Positive_regulation (activation) of Gene_expression (effects) of corticotropin-releasing factor associated with antagonist
7) Confidence 0.49 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.17
Effects of transgenic overproduction of CRH on anxiety-like behaviour.
Positive_regulation (overproduction) of Gene_expression (overproduction) of CRH associated with targeted disruption and anxiety disorder
8) Confidence 0.49 Published 2002 Journal Eur. J. Neurosci. Section Title Doc Link 12099906 Disease Relevance 0.99 Pain Relevance 0.10
Conditioned fear was decreased 1 h but not 24 h after conditioning in transgenic mice, and immobility was decreased [corrected] in forced swimming in corticotropin-releasing hormone overexpressors.
Positive_regulation (overexpressors) of Gene_expression (overexpressors) of corticotropin-releasing hormone associated with targeted disruption and anxiety disorder
9) Confidence 0.49 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12099906 Disease Relevance 1.12 Pain Relevance 0.23
Interestingly, in a transgenic mouse model overexpressing CRH in the entire brain, REM sleep was also significantly enhanced [65], along with a clearly increased responsiveness of the HPA axis to stressors and alterations in emotional behaviour [66], hence largely overlapping with our observations in HR mice (see also [30]).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of CRH in brain associated with targeted disruption
10) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627900 Disease Relevance 0.55 Pain Relevance 0.18
Based on the published data cited above, we would have expected to see increased Npy and decreased Crh expression in the hypothalami of deprived pups.
Positive_regulation (increased) of Gene_expression (expression) of Crh
11) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.23 Pain Relevance 0.03
In P8 pups after 4hr or 8hr of maternal separation, glucose injection led to a 40% and 60% reduction in corticosterone level, respectively, and also reduced the changes in circulating ACTH and hypothalamic CRH levels by half [10].
Positive_regulation (circulating) of Gene_expression (levels) of CRH
12) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.38 Pain Relevance 0.05
In postnatal day 8 or 9 mice, prolonged (>4 hr) maternal separation leads to increased stress as indicated by elevated corticosterone and ACTH in the circulation, as well as reduced corticotropin releasing hormone (CRH) expression in the arcuate nucleus of the hypothalamus [10], [17].
Positive_regulation (elevated) of Gene_expression (expression) of CRH in hypothalamus associated with stress
13) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.36 Pain Relevance 0.03
It is generally accepted that catecholamines which are derived from the nucleus tractus solitaris (NTS)-PVN pathway increase the expression of CRF mRNA, activate CRF releasing neurons, and facilitate the secretion of CRF into the portal blood [for review see [60]].
Positive_regulation (increase) of Gene_expression (expression) of CRF mRNA in blood associated with catecholamine
14) Confidence 0.43 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2845127 Disease Relevance 0.86 Pain Relevance 0.35
In postnatal day 8 or 9 mice, prolonged (>4 hr) maternal separation leads to increased stress as indicated by elevated corticosterone and ACTH in the circulation, as well as reduced corticotropin releasing hormone (CRH) expression in the arcuate nucleus of the hypothalamus [10], [17].
Positive_regulation (elevated) of Gene_expression (expression) of corticotropin releasing hormone in hypothalamus associated with stress
15) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.36 Pain Relevance 0.03
It is also known that exposure to cytokines augments the expression and/or secretion of CRH.
Positive_regulation (augments) of Gene_expression (expression) of CRH associated with cytokine
16) Confidence 0.38 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.22 Pain Relevance 0.12
The latter interesting observation suggests that a physiological concentration of glucocorticoid is important for the stress-induced CRH expression.
Positive_regulation (induced) of Gene_expression (expression) of CRH associated with stress
17) Confidence 0.38 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.25 Pain Relevance 0.06
Moreover, cAMP activator stimulates the endogenous CRH mRNA expression and secretes CRH in culture medium in homologous BE(2)M17 (Kasckow et al. 1994) and BE(2)C cell lines (Kasckow et al. 1995).
Positive_regulation (stimulates) of Gene_expression (expression) of CRH mRNA in C cell
18) Confidence 0.38 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.14 Pain Relevance 0
Consistent with the above findings, most of the vasopressin-positive cells in PVN and SON are co-localized with IL-6, whereas the expression pattern of the CRH-positive cells depends on the type of cells (Gonzalez-Hernandez et al. 2006).
Positive_regulation (depends) of Gene_expression (expression) of CRH
19) Confidence 0.38 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.24 Pain Relevance 0.10
The latter interesting observation suggests that a physiological concentration of glucocorticoid is important for the stress-induced CRH expression.
Positive_regulation (-) of Gene_expression (expression) of CRH associated with stress
20) Confidence 0.38 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.25 Pain Relevance 0.06

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