INT97898

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Context Info
Confidence 0.60
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.85
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF2) extracellular space (FGF2) extracellular region (FGF2)
nucleus (FGF2) cytoplasm (FGF2)
Anatomy Link Frequency
fibroblast 2
neuronal 1
monocytes 1
uterine 1
FGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 3 95.12 Very High Very High Very High
Morphine 12 92.24 High High
Angina 93 91.56 High High
Inflammation 13 84.88 Quite High
anesthesia 2 76.56 Quite High
Central nervous system 2 75.00 Quite High
opiate 2 72.20 Quite High
Neurotransmitter 8 58.24 Quite High
cytokine 16 56.32 Quite High
cva 50 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ankylosis 4 99.56 Very High Very High Very High
Uterine Hemorrhage 1 99.52 Very High Very High Very High
Reprotox - General 3 1 97.68 Very High Very High Very High
Diabetes Mellitus 96 96.92 Very High Very High Very High
Cv General 3 Under Development 90 91.56 High High
Coronary Artery Disease 219 90.76 High High
INFLAMMATION 16 84.88 Quite High
Neurodegenerative Disease 7 80.20 Quite High
Infection 7 77.68 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 10 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Women with leiomyoma-related abnormal uterine bleeding have local dysregulation of bFGF and its type 1 receptor (FGF-R).
Regulation (dysregulation) of bFGF in uterine associated with uterine hemorrhage
1) Confidence 0.60 Published 2001 Journal Menopause Section Abstract Doc Link 11528364 Disease Relevance 0.27 Pain Relevance 0.26
We observed no significant effect on VEGF or bFGF during the 48 hour in vitro fluvastatin treatment.
Neg (no) Regulation (effect) of bFGF
2) Confidence 0.53 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 0.24 Pain Relevance 0
Based on effective concentrations of FGF-2 for periodontal tissue regeneration in animal trials, in addition to the results of our Phase I trial in which FGF-2 was administered intravenously to healthy adult humans, we determined the concentrations and doses administered to periodontal regions of patients in the present clinical trial.
Spec (determined) Regulation (effective) of FGF-2
3) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432040 Disease Relevance 0.16 Pain Relevance 0.05
More specifically, the results of testing with artificial defect models of periodontal tissue in beagles led us to estimate that an effective FGF-2 concentration for stimulation of periodontal tissue regeneration was 0.03–0.3%.
Regulation (effective) of FGF-2
4) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432040 Disease Relevance 0.08 Pain Relevance 0
Computational analysis predicted fibroblast growth factor-2 (FGF-2) as the strongest target gene for hsa-miR15b.
Regulation (target) of fibroblast growth factor-2 in fibroblast
5) Confidence 0.26 Published 2010 Journal J. Cell. Biochem. Section Abstract Doc Link 20564181 Disease Relevance 0.85 Pain Relevance 0.75
Computational analysis predicted fibroblast growth factor-2 (FGF-2) as the strongest target gene for hsa-miR15b.
Regulation (target) of FGF-2 in fibroblast
6) Confidence 0.26 Published 2010 Journal J. Cell. Biochem. Section Abstract Doc Link 20564181 Disease Relevance 0.84 Pain Relevance 0.74
Although the initial values of bFGF and VEGF differed slightly, consistent with the donor variation, the trend for decline of expression was the same.
Regulation (values) of bFGF
7) Confidence 0.23 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 0.07 Pain Relevance 0
Furthermore, we demonstrated with an in vitro cell culture model that the levels of VEGF and bFGF in monocytes of healthy donors are not affected by short term exposure to increased glucose levels (usually observed in the diabetic patients) and/or statin.


Neg (not) Regulation (affected) of bFGF in monocytes associated with diabetes mellitus
8) Confidence 0.23 Published 2003 Journal J Transl Med Section Abstract Doc Link PMC239962 Disease Relevance 1.25 Pain Relevance 0.26
-tubulin III and NF-L in MSCs following bFGF treatment as shown in the present study suggests that B10 differentiate into neuronal progenitor cells and neurons via bFGF-mediated differentiation pathway.
Regulation (following) of bFGF in neuronal
9) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.08 Pain Relevance 0.03

General Comments

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