INT97899

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Context Info
Confidence 0.62
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.99
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FGFR1) extracellular region (FGFR1) cytoplasmic membrane-bounded vesicle (FGFR1)
plasma membrane (FGFR1) nucleus (FGFR1) cytoplasm (FGFR1)
Anatomy Link Frequency
fibroblast 6
epithelium 2
platelet 2
endometrium 2
FGFR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 3 99.72 Very High Very High Very High
Inflammation 48 89.12 High High
chemokine 7 85.88 High High
cytokine 13 84.72 Quite High
metalloproteinase 8 80.16 Quite High
Osteoarthritis 1 73.40 Quite High
ischemia 35 50.44 Quite High
tolerance 2 24.76 Low Low
antagonist 8 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 3 99.72 Very High Very High Very High
Malignant Neoplastic Disease 10 99.42 Very High Very High Very High
Cancer 164 99.32 Very High Very High Very High
Inflammatory Breast Neoplasms 116 98.60 Very High Very High Very High
Pulmonary Disease 52 96.88 Very High Very High Very High
Dermal Scarring 48 93.24 High High
Adhesions 5 93.08 High High
Reprotox - General 3 1 92.52 High High
Uterine Hemorrhage 1 91.44 High High
Metastasis 23 89.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adenomyosis demonstrates increased expression of the basic fibroblast growth factor receptor/ligand system compared with autologous endometrium.
Positive_regulation (increased) of Gene_expression (expression) of basic fibroblast growth factor in endometrium associated with dismenorea
1) Confidence 0.62 Published 2001 Journal Menopause Section Title Doc Link 11528364 Disease Relevance 0.28 Pain Relevance 0.27
An increased expression of FGF-1 and FGF-2 was found by Kranenburg et al. [68] in the bronchial epithelium of COPD patients.
Positive_regulation (increased) of Gene_expression (expression) of FGF-1 in epithelium associated with pulmonary disease
2) Confidence 0.28 Published 2010 Journal Respir Res Section Body Doc Link PMC2955663 Disease Relevance 1.05 Pain Relevance 0
This switch – which is considered a hallmark of the malignancy process – is believed to be stimulated by increased expression of proangiogenic factors such as VEGF, basic fibroblast growth factor, and transforming growth factor ?
Positive_regulation (increased) of Gene_expression (expression) of basic fibroblast growth factor in fibroblast associated with malignant neoplastic disease
3) Confidence 0.07 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 0.89 Pain Relevance 0
P2X receptor antagonism by 100 µM PPADS during OGD led to a peak in SDf-1?
Positive_regulation (led) of Gene_expression (antagonism) of OGD
4) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669296 Disease Relevance 0.05 Pain Relevance 0.07
P2X receptor antagonism by 100 µM PPADS during OGD led to a peak in SDf-1?
Positive_regulation (during) of Gene_expression (antagonism) of OGD
5) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669296 Disease Relevance 0.05 Pain Relevance 0.07
This switch – which is considered a hallmark of the malignancy process – is believed to be stimulated by increased expression of proangiogenic factors such as VEGF, basic fibroblast growth factor, and transforming growth factor ?
Positive_regulation (stimulated) of Gene_expression (expression) of basic fibroblast growth factor in fibroblast associated with malignant neoplastic disease
6) Confidence 0.05 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 0.90 Pain Relevance 0
-actin, basic fibroblast growth factor, vascular endothelial growth factor, platelet-derived growth factor (PDGF), PDGF receptors and integrins ?
Positive_regulation (-) of Gene_expression (receptors) of basic fibroblast growth factor in platelet
7) Confidence 0.04 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.68 Pain Relevance 0.15
Analysis of IBC tumor cell lines and archival tumor specimens demonstrated that high levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor, IL-6, and IL-8 are expressed and secreted by the tumor cells (unpublished data).
Positive_regulation (levels) of Gene_expression (expressed) of basic fibroblast growth factor in fibroblast associated with inflammatory breast neoplasms and cancer
8) Confidence 0.04 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 2.09 Pain Relevance 0.34

General Comments

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