INT97900

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 8.37
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF2) extracellular space (FGF2) extracellular region (FGF2)
nucleus (FGF2) cytoplasm (FGF2)
Anatomy Link Frequency
osteoblast 4
bone marrow 2
pituitary 2
endometrium 2
FGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 3 100.00 Very High Very High Very High
Morphine 6 99.36 Very High Very High Very High
Inflammation 32 91.36 High High
Angina 31 90.56 High High
Dopamine 30 79.76 Quite High
COX-2 inhibitor 8 79.36 Quite High
Central nervous system 1 75.00 Quite High
anesthesia 1 72.44 Quite High
opiate 1 68.08 Quite High
cytokine 21 57.52 Quite High
Disease Link Frequency Relevance Heat
Pituitary Cancer 26 100.00 Very High Very High Very High
Dysmenorrhea 3 100.00 Very High Very High Very High
Eosinophilic Esophagitis 106 99.64 Very High Very High Very High
Gastroesophageal Reflux Disease 36 99.32 Very High Very High Very High
Metastasis 16 98.96 Very High Very High Very High
Osteoporosis 14 98.72 Very High Very High Very High
Leukemia 29 97.70 Very High Very High Very High
Hyperlipidemia 7 97.36 Very High Very High Very High
Hypertension 10 96.28 Very High Very High Very High
Cancer 112 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of note, we observed a decrease in FGF-2 protein expression in response to morphine.
Negative_regulation (decrease) of Gene_expression (expression) of FGF-2 associated with morphine
1) Confidence 0.57 Published 2010 Journal J. Cell. Biochem. Section Abstract Doc Link 20564181 Disease Relevance 0.86 Pain Relevance 0.77
This study was designed to evaluate if adenomyosis expresses bFGF and FGF-R, and if present, to compare bFGF and FGF-R expression in adenomyosis and autologous endometrium.
Negative_regulation (compare) of Gene_expression (expression) of bFGF in endometrium associated with dismenorea
2) Confidence 0.41 Published 2001 Journal Menopause Section Abstract Doc Link 11528364 Disease Relevance 0.46 Pain Relevance 0.27
Bonferroni post hoc comparisons were performed to compare the adjusted levels of VEGF, bFGF and TGF-?
Negative_regulation (compare) of Gene_expression (levels) of bFGF
3) Confidence 0.37 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.22 Pain Relevance 0.22
Differences in bFGF levels between EoE and GERD were also significant (n = 10, mean 1.74 pg/mL, s.e. 0.64 for GERD, p < 0.05) (Figure 3a).
Negative_regulation (Differences) of Gene_expression (levels) of bFGF associated with gastroesophageal reflux disease and eosinophilic esophagitis
4) Confidence 0.20 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.47 Pain Relevance 0.03
In the same manner, the production of bFGF was decreased through the use of all single, double and triple therapy combinations by 60-80%, but without an additional or synergistic effect.
Negative_regulation (decreased) of Gene_expression (production) of bFGF
5) Confidence 0.20 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2841144 Disease Relevance 0.40 Pain Relevance 0.07
"Angiogenesis switch" in leukemia is documented by increased bone marrow MVD, increased expression of HIF-1, multiple pro-angiogenic factors (VEGF, bFGF, angiopoietin-2), soluble VEGFR, and decreased expression of endogenous angiogenesis inhibitors, such as thrombospondin-1 [50,51].
Negative_regulation (decreased) of Gene_expression (expression) of bFGF in bone marrow associated with leukemia
6) Confidence 0.17 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.50 Pain Relevance 0
EGCG inhibited basic fibroblast growth factor-2-induced IL-6 synthesis dose dependently and, in part, via suppression of ERK1/2 and p38 mitogen-activated protein kinase pathways in osteoblast cells [34].
Negative_regulation (inhibited) of Gene_expression (synthesis) of basic fibroblast growth factor-2-induced in osteoblast associated with osteoporosis
7) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.78 Pain Relevance 0
EGCG inhibited basic fibroblast growth factor-2-induced IL-6 synthesis dose dependently and, in part, via suppression of ERK1/2 and p38 mitogen-activated protein kinase pathways in osteoblast cells [34].
Negative_regulation (suppression) of Gene_expression (synthesis) of basic fibroblast growth factor-2-induced in osteoblast associated with osteoporosis
8) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.78 Pain Relevance 0
In fact, abundant and concordant PTTG and bFGF expression in different human pituitary tumors was described [4].
Negative_regulation (described) of Gene_expression (expression) of bFGF in pituitary associated with pituitary cancer
9) Confidence 0.05 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 0.91 Pain Relevance 0.12

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