INT97902

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Context Info
Confidence 0.11
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 13.45
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (AGGF1) cell adhesion (AGGF1) intracellular (AGGF1)
cytoplasm (AGGF1)
Anatomy Link Frequency
bone marrow 2
chondrocytes 1
myometrium 1
TMJ 1
endometrium 1
AGGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 107 99.96 Very High Very High Very High
Inflammation 77 99.36 Very High Very High Very High
Snapping jaw 6 99.24 Very High Very High Very High
chemokine 76 95.12 Very High Very High Very High
Dismenorea 6 85.12 High High
metalloproteinase 122 83.52 Quite High
Osteoarthritis 100 81.44 Quite High
Potency 6 78.24 Quite High
imagery 11 73.44 Quite High
palliative 4 60.36 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 84 99.98 Very High Very High Very High
Asthma 57 99.68 Very High Very High Very High
Leukemia 92 99.42 Very High Very High Very High
INFLAMMATION 87 99.36 Very High Very High Very High
Temporomandibular Joint Syndrome 6 99.24 Very High Very High Very High
Osteoarthritis 6 98.68 Very High Very High Very High
Multiple Myeloma 132 98.32 Very High Very High Very High
Metastasis 98 98.28 Very High Very High Very High
Ovarian Cancer 3 97.84 Very High Very High Very High
Osteogenic Sarcomas 58 97.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVES: Basic fibroblast growth factor (bFGF) is an angiogenic growth factor present in human endometrium and myometrium.
Gene_expression (present) of angiogenic growth factor in endometrium
1) Confidence 0.11 Published 2001 Journal Menopause Section Abstract Doc Link 11528364 Disease Relevance 0.27 Pain Relevance 0.24
Many inflammatory cells are probably involved as angiogenic growth factor sources in the asthmatic airways.
Gene_expression (sources) of angiogenic growth factor associated with asthma and inflammation
2) Confidence 0.06 Published 2010 Journal Respir Res Section Body Doc Link PMC2955663 Disease Relevance 0.67 Pain Relevance 0.27
Knockdown of Her-2/neu expression by siRNA is associated with increased expression of the anti-angiogenic factor THBS-1 and decreased expression of VEGF in human breast and ovarian cancer.
Gene_expression (expression) of anti-angiogenic factor THBS-1 associated with ovarian cancer
3) Confidence 0.05 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.73 Pain Relevance 0
Protease inhibitor upregulation alongside increased angiogenic factor expression however may moderate osteochondral angiogenesis, for example by inhibiting receptor shedding or growth factor activation.
Gene_expression (expression) of angiogenic factor
4) Confidence 0.04 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2877870 Disease Relevance 0.34 Pain Relevance 0.14
OBJECTIVES: Basic fibroblast growth factor (bFGF) is an angiogenic growth factor present in human endometrium and myometrium.
Gene_expression (present) of angiogenic growth factor in myometrium
5) Confidence 0.04 Published 2001 Journal Menopause Section Abstract Doc Link 11528364 Disease Relevance 0.27 Pain Relevance 0.24
We have shown that osteoarthritic articular cartilage contains chondrocytes that display increased expression of the angiogenic factor VEGF, and also of a variety of protease inhibitors that are known to have anti-angiogenic activity.
Gene_expression (expression) of angiogenic factor in chondrocytes associated with osteoarthritis
6) Confidence 0.03 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2877870 Disease Relevance 0.39 Pain Relevance 0.10
In this study, we investigated the expression of the anti-angiogenic factor, chondromodulin-1 (ChM-1), in TMJ cartilage and evaluate its potential role in TMJ remodeling.
Spec (investigated) Gene_expression (expression) of anti-angiogenic factor in TMJ associated with snapping jaw
7) Confidence 0.02 Published 2010 Journal J. Oral Pathol. Med. Section Abstract Doc Link 19903245 Disease Relevance 0.54 Pain Relevance 0.54
Local angiogenesis is determined by an imbalance in the over-expression of pro-angiogenic factors, as compared to inhibitors of angiogenesis.
Gene_expression (expression) of pro-angiogenic
8) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.76 Pain Relevance 0.23
Local angiogenesis is determined by an imbalance in the over-expression of pro-angiogenic factors, as compared to inhibitors of angiogenesis.
Gene_expression (over) of pro-angiogenic
9) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.76 Pain Relevance 0.23
-TCP and angiogenic factor-enriched PRP showed a 59% higher periosteal perfusion than those grafted with ?
Gene_expression (showed) of angiogenic factor-enriched
10) Confidence 0.01 Published 2010 Journal The Journal of Advanced Prosthodontics Section Body Doc Link PMC2984511 Disease Relevance 0.09 Pain Relevance 0.04
Pancreatic cancers expressing high levels of vascular endothelial growth factor, a potent pro-angiogenic cytokine, also have a higher incidence of metastasis and poorer prognosis.
Gene_expression (expressing) of pro-angiogenic associated with pancreatic cancer, metastasis and cytokine
11) Confidence 0.01 Published 2003 Journal Mol Cancer Section Abstract Doc Link PMC150383 Disease Relevance 1.77 Pain Relevance 0.05
In this present study, we attempted to determine by immunohistochemistry, whether increased microvessel density or the expression of pro-angiogenic factors, such as VEGF, in older patients might be an attributable factor in the poorer prognosis in this age group.
Gene_expression (expression) of pro-angiogenic
12) Confidence 0.01 Published 2006 Journal Int Semin Surg Oncol Section Body Doc Link PMC1435760 Disease Relevance 0.63 Pain Relevance 0
In this present study, the aims were two-fold; firstly to describe our institution's experience with the management of osteosarcoma in older patients, and secondly to determine whether there was any correlation between the intratumoural microvessel density or the degree of pro-angiogenic factor expression (VEGF) and patient age.
Gene_expression (expression) of pro-angiogenic factor associated with osteogenic sarcomas
13) Confidence 0.01 Published 2006 Journal Int Semin Surg Oncol Section Body Doc Link PMC1435760 Disease Relevance 0.73 Pain Relevance 0
"Angiogenesis switch" in leukemia is documented by increased bone marrow MVD, increased expression of HIF-1, multiple pro-angiogenic factors (VEGF, bFGF, angiopoietin-2), soluble VEGFR, and decreased expression of endogenous angiogenesis inhibitors, such as thrombospondin-1 [50,51].
Gene_expression (expression) of pro-angiogenic in bone marrow associated with leukemia
14) Confidence 0.01 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.49 Pain Relevance 0
Moreover, it was also shown that urine and peripheral blood samples from ALL patients contained elevated levels of pro-angiogenic growth factors, namely bFGF and VEGF, which correlated with the increase of bone marrow angiogenesis [48].
Gene_expression (levels) of pro-angiogenic in urine associated with leukemia
15) Confidence 0.01 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.35 Pain Relevance 0
Thalidomide and the newer immunomodulatory drugs (IMiDs) (e.g. lenalidomide) have been shown to significantly decrease the expression of the pro-angiogenic factors VEGF and Interleukin-6 (IL-6) in MM [87].
Gene_expression (expression) of pro-angiogenic associated with multiple myeloma
16) Confidence 0.01 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 0.50 Pain Relevance 0.06
"Angiogenesis switch" in leukemia is documented by increased bone marrow MVD, increased expression of HIF-1, multiple pro-angiogenic factors (VEGF, bFGF, angiopoietin-2), soluble VEGFR, and decreased expression of endogenous angiogenesis inhibitors, such as thrombospondin-1 [50,51].
Gene_expression (expression) of pro-angiogenic in bone marrow associated with leukemia
17) Confidence 0.01 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.56 Pain Relevance 0
One of the mechanisms modulated by COX-2 during carcinogenesis is angiogenesis, presumably through increased production of the most potent and extensively studied pro-angiogenic factor, VEGF [45].
Gene_expression (production) of pro-angiogenic factor
18) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.60 Pain Relevance 0.36

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