INT97905

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 33
Total Number 33
Disease Relevance 26.74
Pain Relevance 5.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF2) extracellular space (FGF2) extracellular region (FGF2)
nucleus (FGF2) cytoplasm (FGF2)
Anatomy Link Frequency
plasma 5
coronary artery 2
synovial fluid 1
striatum 1
fibroblast 1
FGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 105 100.00 Very High Very High Very High
ischemia 28 99.80 Very High Very High Very High
rheumatoid arthritis 88 99.44 Very High Very High Very High
depression 46 99.16 Very High Very High Very High
Hippocampus 17 98.32 Very High Very High Very High
fluoxetine 4 96.34 Very High Very High Very High
antidepressant 8 96.12 Very High Very High Very High
sSRI 6 95.82 Very High Very High Very High
cytokine 159 95.68 Very High Very High Very High
metalloproteinase 10 94.16 High High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 102 100.00 Very High Very High Very High
Osteoporosis 17 100.00 Very High Very High Very High
Eosinophilic Esophagitis 954 99.84 Very High Very High Very High
Coronary Artery Disease 225 99.80 Very High Very High Very High
Cv Unclassified Under Development 21 99.76 Very High Very High Very High
Leukemia 25 99.60 Very High Very High Very High
Rheumatoid Arthritis 89 99.44 Very High Very High Very High
Diabetes Mellitus 142 99.32 Very High Very High Very High
Depression 56 99.16 Very High Very High Very High
Cancer 169 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: FGF-2 levels are elevated in the human synovial fluid of TMJs with internal derangement.


Positive_regulation (elevated) of FGF-2 in synovial fluid
1) Confidence 0.70 Published 2003 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 14676757 Disease Relevance 0 Pain Relevance 0
The level of VEGF in pericardial fluid was increased only in patients with severe rest angina within 2 days before emergency coronary artery bypass graft surgery (CABG), while bFGF was increased in all patients undergoing CABG for coronary artery disease.
Positive_regulation (increased) of bFGF in coronary artery associated with angina, coronary artery disease and emergencies
2) Confidence 0.67 Published 1998 Journal Angiogenesis Section Abstract Doc Link 14517380 Disease Relevance 0.80 Pain Relevance 0.49
Although we reported that basic fibroblast growth factor (bFGF) levels in pericardial fluid of patients with unstable angina are apparently increased, it was unclear whether vascular endothelial growth factor (VEGF) is also increased in patients with myocardial ischemia.
Positive_regulation (increased) of bFGF in pericardial fluid associated with angina, coronary artery disease and ischemia
3) Confidence 0.67 Published 1998 Journal Angiogenesis Section Abstract Doc Link 14517380 Disease Relevance 0.54 Pain Relevance 0.43
FGF-2 activity for IL-6 induction was the same as that of IL-17.
Positive_regulation (activity) of FGF-2
4) Confidence 0.66 Published 2004 Journal Pancreas Section Body Doc Link 15502643 Disease Relevance 0 Pain Relevance 0
BMI resulted in lower levels of VEGF and bFGF, and this fall is the hallmark of the effectiveness of BMI in the treatment of peripheral artery disease.
Positive_regulation (resulted) of bFGF in artery associated with peripheral arterial disease
5) Confidence 0.65 Published 2006 Journal Angiology Section Abstract Doc Link 16518534 Disease Relevance 0.42 Pain Relevance 0.20
Stromal staining for bFGF and PCNA was significantly increased in adenomyosis compared with autologous endometrium.
Positive_regulation (increased) of bFGF in endometrium
6) Confidence 0.49 Published 2001 Journal Menopause Section Body Doc Link 11528364 Disease Relevance 0.15 Pain Relevance 0
FGF-2 activity for IL-6 induction was the same as that of IL-17.
Positive_regulation (induction) of FGF-2
7) Confidence 0.44 Published 2004 Journal Pancreas Section Body Doc Link 15502643 Disease Relevance 0 Pain Relevance 0
Moreover, recent work in rats has shown that a combination of the SSRI antidepressant fluoxetine and the atypical antipsychotic drug olanzapine, which appear in human studies to be more effective for the treatment of resistant depression in combination than individually, led to increased levels of FGF2 mRNA in prefrontal cortex, as well as in hippocampus and striatum [8].
Positive_regulation (increased) of FGF2 in hippocampus associated with antidepressant, depression, hippocampus, ssri and fluoxetine
8) Confidence 0.44 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 0.92 Pain Relevance 0.62
The high level of serum VEGF and bFGF reported in other stages of atherosclerosis should be accredited to other potential sites of production like the atherosclerotic lesion itself.
Positive_regulation (level) of bFGF associated with atherosclerosis
9) Confidence 0.43 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.12 Pain Relevance 0.26
Our findings display a statistically significant association of the increased VEGF and bFGF levels in peripheral monocytes, with stable angina and diabetes in coronary artery disease.
Positive_regulation (increased) of bFGF in coronary artery associated with angina, coronary artery disease and diabetes mellitus
10) Confidence 0.40 Published 2003 Journal J Transl Med Section Abstract Doc Link PMC239962 Disease Relevance 1.23 Pain Relevance 0.26
The plasma fluid assay data provided here show that bFGF was upregulated in EoE subjects.
Positive_regulation (upregulated) of bFGF in plasma associated with eosinophilic esophagitis
11) Confidence 0.38 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.07 Pain Relevance 0
Fluid Assays on plasma show highly elevated bFGF specifically in EoE subjects
Positive_regulation (elevated) of bFGF in plasma associated with eosinophilic esophagitis
12) Confidence 0.38 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.80 Pain Relevance 0
Along with bFGF upregulation, an increase in eotaxin was also seen in EoE subjects.
Positive_regulation (upregulation) of bFGF associated with eosinophilic esophagitis
13) Confidence 0.38 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.98 Pain Relevance 0
In plasma from HC subjects (n = 10), bFGF levels were low (mean 0.13 pg/mL, s.e. 0.09 pg/mL) while bFGF was significantly upregulated in EoE subjects (n = 10, mean 81.98 pg/mL, s.e. 17.23 pg/mL for EoE, p < 0.05).
Positive_regulation (upregulated) of bFGF in plasma associated with eosinophilic esophagitis
14) Confidence 0.38 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.37 Pain Relevance 0
The extent of the increases in ERK was correlated with bFGF increases in expression (R = 0.89, p < 0.05) (Figure 2a) and with eotaxin increases in expression (R= 0.82, p < 0.05) (Figure 2b).
Positive_regulation (increases) of bFGF
15) Confidence 0.38 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.09 Pain Relevance 0
Panutsopulos D et al. were also able to demonstrate an impairment of monocyte migration with an associated increase in basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) mRNA [39].
Positive_regulation (increase) of bFGF in monocyte
16) Confidence 0.35 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 0.95 Pain Relevance 0.22
Following neural induction with bFGF and forskolin, hADSCs were differentiated into various types of neural cells including neurons and glia in vitro.
Positive_regulation (induction) of bFGF in neurons
17) Confidence 0.35 Published 2010 Journal BMC Cell Biol Section Abstract Doc Link PMC2867791 Disease Relevance 0.34 Pain Relevance 0
PGE2 induced by COX-2 exerts several biological properties that may be advantageous for tumorigenesis: 1) Promoting angiogenesis (increased VEGF, bFGF, and PDGF production), 2) Anti-apoptosis mechanism (via increased bcl-2 and Akt activity), 3) Stimulating tumor metastasis (by increasing matrix metalloproteinases) and 4) Decreased immune surveillance (decreased cytokine production and NK activity).
Positive_regulation (increased) of bFGF associated with metalloproteinase, apoptosis, metastasis and cytokine
18) Confidence 0.29 Published 2004 Journal Front. Biosci. Section Abstract Doc Link 15353307 Disease Relevance 0.73 Pain Relevance 0.25
Since we found bFGF and other immune indicators to be specifically increased in PBMCs of EoE subjects, we then performed fluid assays to determine whether they were present systemically in the plasma.
Positive_regulation (increased) of bFGF in plasma associated with eosinophilic esophagitis
19) Confidence 0.27 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.91 Pain Relevance 0
As in primary human MSCs, B10 cells express high levels of NGF, BDNF, CNTF, GDNF, bFGF, IGF-I, HGF and VEGF (Figure 10).
Positive_regulation (levels) of bFGF in HGF
20) Confidence 0.27 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.25 Pain Relevance 0.20

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