INT97909

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Context Info
Confidence 0.37
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 5.98
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COMP) extracellular region (COMP) cell adhesion (COMP)
proteinaceous extracellular matrix (COMP)
Anatomy Link Frequency
cartilage 2
chondrocytes 1
joint 1
extracellular matrix 1
COMP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 42 97.68 Very High Very High Very High
anesthesia 2 96.58 Very High Very High Very High
epidural 3 96.36 Very High Very High Very High
Pain 15 94.32 High High
rheumatoid arthritis 46 86.64 High High
Inflammation 13 83.64 Quite High
analgesia 1 79.36 Quite High
cINOD 1 71.40 Quite High
Arthritis 56 56.72 Quite High
cytokine 2 39.28 Quite Low
Disease Link Frequency Relevance Heat
Osteochondrodysplasias 69 99.90 Very High Very High Very High
Congenital Anomalies 15 99.68 Very High Very High Very High
Cleidocranial Dysplasia 8 99.20 Very High Very High Very High
Growth Problems 6 99.08 Very High Very High Very High
Disease 47 98.56 Very High Very High Very High
Heart Rate Under Development 39 97.92 Very High Very High Very High
Frailty 6 97.68 Very High Very High Very High
Chondrodysplasia 2 97.04 Very High Very High Very High
Osteoarthritis 40 96.08 Very High Very High Very High
Arthralgia 2 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
70° for subsequent assay of COMP and C-reactive protein (CRP).
COMP Binding (assay) of
1) Confidence 0.37 Published 2010 Journal Clin Med Insights Arthritis Musculoskelet Disord Section Body Doc Link PMC2989640 Disease Relevance 0.36 Pain Relevance 0.14
Functional studies have shown that COMP binds types II and IX collagens but the role of COMP in the extracellular matrix remains to be defined.
COMP Binding (binds) of in extracellular matrix
2) Confidence 0.36 Published 2004 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 15094116 Disease Relevance 0.26 Pain Relevance 0.04
Multiple epiphyseal dysplasia (MED) is a rare autosomal dominant skeletal dysplasia caused by abnormalities in the gene(s) coding for type IX collagen and cartilage oligomeric matrix protein.
cartilage oligomeric matrix protein Binding (coding) of in cartilage associated with osteochondrodysplasias, congenital anomalies and cleidocranial dysplasia
3) Confidence 0.36 Published 2009 Journal J Arthroplasty Section Abstract Doc Link 18789631 Disease Relevance 0.87 Pain Relevance 0.22
Only infected cells were considered in this analysis because the shRNA targets the human COMP transcript and does not cross-react with rat COMP.
COMP Neg (not) Binding (cross) of
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.24 Pain Relevance 0
Only infected cells were considered in this analysis because the shRNA targets the human COMP transcript and does not cross-react with rat COMP.
COMP Binding (react) of
5) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.24 Pain Relevance 0
Serum COMP during intervention
COMP Binding (intervention) of
6) Confidence 0.33 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712338 Disease Relevance 0.05 Pain Relevance 0
Pseudoachondroplasia (PSACH) is a well-characterized dwarfing condition associated with disproportionate short stature, abnormal joints and osteoarthritis requiring joint replacement.
PSACH Binding (associated) of in joint associated with frailty, osteoarthritis and growth problems
7) Confidence 0.32 Published 2004 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 15094116 Disease Relevance 0.29 Pain Relevance 0.05
Recently, using flouresence deconvolution analysis, these retained proteins were shown to be organized into a matrix network suggesting that the stalled mutant COMP inappropriately interacts intracellularly with matrix protein partners [9], [10], [11].
mutant COMP Binding (interacts) of
8) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.63 Pain Relevance 0.04
Recently there has been much speculation about the reason for this genetic heterogeneity, and a number of hypotheses have been suggested; i.e., 1) some mutations disrupt specific interactions between matrilin-3, type IX collagen, and COMP in the cartilage ECM [Briggs and Chapman, 2002]; 2) the blocked/delayed secretion of one mutant protein results in a cascade of protein retention within the rER of chondrocytes [Unger and Hecht, 2001]; or 3) a combination of both mechanisms [Dinser et al., 2002].
COMP Binding (interactions) of in chondrocytes
9) Confidence 0.31 Published 2005 Journal Human Mutation Section Body Doc Link PMC2726956 Disease Relevance 0.37 Pain Relevance 0
The type I collagen degradation marker ICTP (C-terminal telopeptide of type I collagen) and the cartilage markers CTX-II (C-terminal telopeptide fragments of type II collagen) and cartilage oligomeric matrix protein (COMP) were associated with the Larsen score at baseline.
cartilage oligomeric matrix protein Binding (associated) of in cartilage
10) Confidence 0.24 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0.46 Pain Relevance 0.17
Based on discordant inheritance among affected individuals linkage of the phenotype to the COMP, COL9A1, COL9A2, COL9A3 genes was excluded.
COMP Binding (linkage) of
11) Confidence 0.15 Published 2001 Journal Eur. J. Hum. Genet. Section Abstract Doc Link 11528506 Disease Relevance 0.89 Pain Relevance 0.09
Clinical and radiographic features of multiple epiphyseal dysplasia not linked to the COMP or type IX collagen genes.
COMP Binding (linked) of associated with osteochondrodysplasias
12) Confidence 0.15 Published 2001 Journal Eur. J. Hum. Genet. Section Title Doc Link 11528506 Disease Relevance 0.94 Pain Relevance 0.07
The baseline bias on the Bland-Altman plot in that study was nearly identical to the bias seen for male patients in our study.[17] However, following institution of lumbar epidural anesthesia, the EDM actually overestimated cardiac output relative to the PAC by approximately 0.51 liters/min.[17] Summary of major published series demonstrating measurement bias associated with EDM in various clinical setting use can be found in Table 3.
EDM Binding (associated) of associated with heart rate under development, anesthesia and epidural
13) Confidence 0.01 Published 2007 Journal Annals of Thoracic Medicine Section Body Doc Link PMC2732095 Disease Relevance 0.38 Pain Relevance 0.39

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