INT9794

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Context Info
Confidence 0.43
First Reported 1990
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 1.49
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck) DNA binding (Cck)
Anatomy Link Frequency
striatum 6
hippocampus 2
Cck (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 214 100.00 Very High Very High Very High
Enkephalin 8 100.00 Very High Very High Very High
Dynorphin 2 100.00 Very High Very High Very High
Dopamine 6 99.84 Very High Very High Very High
Neuropeptide 8 99.76 Very High Very High Very High
medulla 54 99.70 Very High Very High Very High
Hippocampus 5 98.24 Very High Very High Very High
antagonist 31 94.76 High High
Pain 77 90.00 High High
Intracerebroventricular 2 81.76 Quite High
Disease Link Frequency Relevance Heat
Convulsion 12 100.00 Very High Very High Very High
Cancer 76 99.08 Very High Very High Very High
Pain 80 90.00 High High
Pancreatic Cancer 17 50.00 Quite Low
Peripheral Arterial Disease 2 34.68 Quite Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Aids-related Complex 10 5.00 Very Low Very Low Very Low
Neuropathic Pain 9 5.00 Very Low Very Low Very Low
Skin Cancer 8 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
g/kg determined in a preliminary study), unlike fasted outbred NMRI mice that were sensitive to CCK-8 dose of 4 ?
Regulation (sensitive) of Gene_expression (dose) of CCK-8 associated with cholecystokinin
1) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0 Pain Relevance 0.55
Fos immunoreactivity in NTS, PVN, and DMH after CART peptide and CCK administration
Regulation (after) of Gene_expression (administration) of CCK associated with medulla and cholecystokinin
2) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0 Pain Relevance 0.55
These results suggest that the dopaminergic nigrostriatal pathway directly, or indirectly, regulates the expression of cholecystokinin messenger RNA in the striatum.
Regulation (regulates) of Gene_expression (expression) of cholecystokinin messenger RNA in striatum associated with cholecystokinin
3) Confidence 0.36 Published 1992 Journal Neuroscience Section Abstract Doc Link 1436504 Disease Relevance 0 Pain Relevance 0.39
Conversely, treatment with either haloperidol or SCH23390 for two weeks did not induce any detectable changes in cholecystokinin messenger RNA expression in the striatum while, as expected, an increase in the striatal enkephalin messenger RNA content was observed.
Neg (not) Regulation (changes) of Gene_expression (expression) of cholecystokinin messenger RNA in striatum associated with enkephalin and cholecystokinin
4) Confidence 0.36 Published 1992 Journal Neuroscience Section Abstract Doc Link 1436504 Disease Relevance 0 Pain Relevance 0.41
In situ hybridization histochemistry was used to investigate the putative regulation of cholecystokinin messenger RNA expression by dopamine in the rat striatum.
Spec (investigate) Regulation (regulation) of Gene_expression (expression) of cholecystokinin messenger RNA in striatum associated with dopamine and cholecystokinin
5) Confidence 0.36 Published 1992 Journal Neuroscience Section Abstract Doc Link 1436504 Disease Relevance 0 Pain Relevance 0.27
In studies described here, we examined the influence of recurrent limbic seizures on the expression of enkephalin, dynorphin, cholecystokinin, and neuropeptide Y (NPY) in rat and mouse hippocampus using immunohistochemical, in situ hybridization and blot hybridization techniques.
Spec (examined) Regulation (influence) of Gene_expression (expression) of cholecystokinin in hippocampus associated with convulsion, dynorphin, neuropeptide, hippocampus, enkephalin and cholecystokinin
6) Confidence 0.33 Published 1990 Journal Prog. Brain Res. Section Abstract Doc Link 2203104 Disease Relevance 0.49 Pain Relevance 0.61
in the cancer-inoculated region, we examined the effect of sulfated CCK-8 injection on IL-1?
Spec (examined) Regulation (sulfated) of Gene_expression (injection) of CCK-8 associated with cancer
7) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 0.99 Pain Relevance 0.32

General Comments

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