INT97943

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Context Info
Confidence 0.28
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 7.40
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleolus (Casp3) nucleus (Casp3) intracellular (Casp3)
Anatomy Link Frequency
poly 6
cleavage 6
brain 2
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 28 97.36 Very High Very High Very High
aspirin 5 94.72 High High
local anesthetic 10 87.88 High High
antagonist 8 85.52 High High
metalloproteinase 2 84.64 Quite High
cINOD 2 75.00 Quite High
Inflammation 4 69.64 Quite High
cytokine 9 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 113 99.56 Very High Very High Very High
Cancer 83 99.04 Very High Very High Very High
Cv Unclassified Under Development 12 97.36 Very High Very High Very High
Hypoxia 102 95.20 Very High Very High Very High
Injury 48 94.56 High High
Death 37 91.44 High High
Alagille Syndrome 2 91.40 High High
Middle Cerebral Artery Infarction 31 88.80 High High
Body Weight 4 88.16 High High
Stomach Cancer 5 82.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
induced cleavage of caspase-3 and promoted apoptosis in cultured brain microvascular endothelial cells.
Positive_regulation (induced) of Protein_catabolism (cleavage) of caspase-3 in brain associated with apoptosis
1) Confidence 0.28 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.92 Pain Relevance 0.18
Specific caspase-3 activity was assessed using a caspase-3 assay, which could measure the cleavage of the caspase-3 specific substrate Ac-DEVD-pNA (Fig. 4).
Positive_regulation (measure) of Protein_catabolism (cleavage) of caspase-3 in cleavage
2) Confidence 0.14 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 1.06 Pain Relevance 0
Specific caspase-3 activity was assessed using a caspase-3 assay, which could measure the cleavage of the caspase-3 specific substrate Ac-DEVD-pNA (Fig. 4).
Positive_regulation (measure) of Protein_catabolism (cleavage) of caspase-3 in cleavage
3) Confidence 0.14 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 1.09 Pain Relevance 0
Apoptosis was accompanied by an increase in caspase-3 activity and cleavage of caspase-3 and poly(ADP-ribose) polymerase.
Positive_regulation (increase) of Protein_catabolism (cleavage) of caspase-3 in poly associated with apoptosis
4) Confidence 0.12 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11532860 Disease Relevance 1.47 Pain Relevance 0.35
Cleaved caspase 3 is an apoptotic marker, and the results showed that BP treatment increased the cleavage of caspase 3 protein to induce apoptosis of tumor cells in vivo (Fig. 3d).
Positive_regulation (increased) of Protein_catabolism (cleavage) of caspase 3 protein in cleavage associated with cancer and apoptosis
5) Confidence 0.06 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 1.51 Pain Relevance 0
The bupivacaine-induced generation of reactive oxygen species (ROS), which was initiated within 5 hrs and preceded the activation of caspase-3 and poly ADP-ribose polymerase (PARP) degradation, was suggested to trigger apoptosis, exhibited by Hoechst 33258 nuclear staining and DNA fragmentation.
Positive_regulation (preceded) of Protein_catabolism (degradation) of caspase-3 in poly associated with apoptosis
6) Confidence 0.04 Published 2005 Journal J. Dent. Res. Section Abstract Doc Link 16109997 Disease Relevance 0.68 Pain Relevance 0.41
The bupivacaine-induced generation of reactive oxygen species (ROS), which was initiated within 5 hrs and preceded the activation of caspase-3 and poly ADP-ribose polymerase (PARP) degradation, was suggested to trigger apoptosis, exhibited by Hoechst 33258 nuclear staining and DNA fragmentation.
Positive_regulation (activation) of Protein_catabolism (degradation) of caspase-3 in poly associated with apoptosis
7) Confidence 0.03 Published 2005 Journal J. Dent. Res. Section Abstract Doc Link 16109997 Disease Relevance 0.67 Pain Relevance 0.41

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