INT97949

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Context Info
Confidence 0.06
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (NRP2, CDC42) cell differentiation (NRP2) intracellular (CDC42)
GTPase activity (CDC42) microtubule organizing center (CDC42) cytoplasm (CDC42)
Anatomy Link Frequency
fibroblast 3
NRP2 (Homo sapiens)
CDC42 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 6 100.00 Very High Very High Very High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 6 98.68 Very High Very High Very High
Adhesions 1 96.76 Very High Very High Very High
INFLAMMATION 1 85.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we show that inhibition of endothelial-cell COX-2 by NSAIDs suppresses alpha V beta 3-dependent activation of the small GTPases Cdc42 and Rac, resulting in inhibition of endothelial-cell spreading and migration in vitro and suppression of fibroblast growth factor-2-induced angiogenesis in vivo.
Negative_regulation (inhibition) of endothelial-cell COX-2 in fibroblast Negative_regulation (suppresses) of Positive_regulation (activation) of Cdc42 in fibroblast associated with cinod
1) Confidence 0.06 Published 2001 Journal Nat. Med. Section Abstract Doc Link 11533708 Disease Relevance 0.72 Pain Relevance 0.51

General Comments

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