INT9795

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Context Info
Confidence 0.50
First Reported 1992
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.34
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck) DNA binding (Cck)
Anatomy Link Frequency
striatum 4
brain 2
forebrain 2
body 2
Cck (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 36 100.00 Very High Very High Very High
Enkephalin 11 100.00 Very High Very High Very High
Neuropeptide 5 100.00 Very High Very High Very High
antagonist 2 100.00 Very High Very High Very High
Dopamine 6 97.30 Very High Very High Very High
Opioid 2 78.96 Quite High
Hippocampus 2 53.16 Quite High
cerebral cortex 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Thalamus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurological Disease 1 95.84 Very High Very High Very High
Hypertrophy 1 90.96 High High
Convulsion 1 88.28 High High
Targeted Disruption 2 63.72 Quite High
Pain 1 5.00 Very Low Very Low Very Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: The high expression of the CCK gene in the brain can decrease body weight and increase plasma glucose.
Positive_regulation (increase) of Gene_expression (expression) of CCK gene in body
1) Confidence 0.50 Published 2009 Journal Chin. Med. J. Section Body Doc Link 19781389 Disease Relevance 0.06 Pain Relevance 0
In contrast, 3R[+]-N-[2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-benzodiazepin-3-yl ]-N'- [3-methyl-phenyl]urea (L365,260), a selective CCKB receptor antagonist, blocked the action of CCK4(30-33) and SNF 9007 (phase I), and also antagonized CCK8(s), though to a lesser degree.
Positive_regulation (selective) of Gene_expression (antagonist) of CCK associated with antagonist
2) Confidence 0.49 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8113956 Disease Relevance 0 Pain Relevance 0.31
Dopamine depletion caused by a 6-hydroxydopamine injection in the medical forebrain bundle induced, two and four weeks after the injection, an increase of cholecystokinin messenger RNA expression in the ipsilateral striatum.
Positive_regulation (increase) of Gene_expression (expression) of cholecystokinin messenger RNA in forebrain associated with dopamine and cholecystokinin
3) Confidence 0.41 Published 1992 Journal Neuroscience Section Abstract Doc Link 1436504 Disease Relevance 0 Pain Relevance 0.36
Lesion of the nigrostriatal pathway induces cholecystokinin messenger RNA expression in the rat striatum.
Positive_regulation (induces) of Gene_expression (expression) of cholecystokinin messenger RNA in striatum associated with enkephalin and cholecystokinin
4) Confidence 0.41 Published 1992 Journal Neuroscience Section Title Doc Link 1436504 Disease Relevance 0 Pain Relevance 0.49
Expression of cholecystokinin, enkephalin, galanin and neuropeptide Y is markedly changed in the brain of the megencephaly mouse.
Positive_regulation (changed) of Gene_expression (Expression) of cholecystokinin in brain associated with neuropeptide, enkephalin and cholecystokinin
5) Confidence 0.31 Published 2000 Journal Neuroscience Section Title Doc Link 11008168 Disease Relevance 0.28 Pain Relevance 0.69
Conversely, treatment with either haloperidol or SCH23390 for two weeks did not induce any detectable changes in cholecystokinin messenger RNA expression in the striatum while, as expected, an increase in the striatal enkephalin messenger RNA content was observed.
Neg (not) Positive_regulation (induce) of Gene_expression (expression) of cholecystokinin messenger RNA in striatum associated with enkephalin and cholecystokinin
6) Confidence 0.27 Published 1992 Journal Neuroscience Section Abstract Doc Link 1436504 Disease Relevance 0 Pain Relevance 0.42

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