INT97956

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Context Info
Confidence 0.27
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.58
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDC42) plasma membrane (CDC42) cytoskeleton (CDC42)
intracellular (CDC42) GTPase activity (CDC42) cell division (CDC42)
CDC42 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 7 99.98 Very High Very High Very High
COX2 1 99.86 Very High Very High Very High
Glutamate 6 9.40 Low Low
antagonist 8 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Glutamate receptor 5 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 6 97.84 Very High Very High Very High
Death 3 97.32 Very High Very High Very High
Cancer 25 93.32 High High
INFLAMMATION 7 91.32 High High
Genomic Instability 9 80.32 Quite High
Adhesions 5 79.44 Quite High
Aneuploidy 22 75.28 Quite High
Polyploidy 8 60.60 Quite High
Chromosomal Instability 1 53.68 Quite High
Obesity 3 32.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis.
Negative_regulation (inhibit) of Cdc42 associated with cinod
1) Confidence 0.27 Published 2001 Journal Nat. Med. Section Title Doc Link 11533708 Disease Relevance 0.69 Pain Relevance 0.55
-treated hFPHEK cells could interfere with the bi-attachment of the kinetochore to microtubules by depleting ECT2 activity toward Cdc42.
Negative_regulation (depleting) of Cdc42
2) Confidence 0.20 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0.60 Pain Relevance 0
In this study, we observed that genes implied in proliferation (SPD35, CDC20, GPC4, CDC42) were downregulated but no variation of gene expression involved in cell apoptosis or death were observed (DAPK3, PDCD2, APAF1, ACIN1).
Negative_regulation (downregulated) of CDC42 associated with apoptosis and death
3) Confidence 0.14 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.29 Pain Relevance 0

General Comments

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