INT9796

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Context Info
Confidence 0.78
First Reported 1982
Last Reported 2010
Negated 5
Speculated 4
Reported most in Abstract
Documents 63
Total Number 67
Disease Relevance 11.44
Pain Relevance 32.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck) DNA binding (Cck)
Anatomy Link Frequency
neurons 6
brain 5
striatum 5
mossy fiber 4
fat 2
Cck (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 1263 100.00 Very High Very High Very High
medulla 376 100.00 Very High Very High Very High
antagonist 198 100.00 Very High Very High Very High
Neuropeptide 69 100.00 Very High Very High Very High
Enkephalin 56 100.00 Very High Very High Very High
Dynorphin 17 100.00 Very High Very High Very High
bradykinin 4 100.00 Very High Very High Very High
antinociception 10 99.98 Very High Very High Very High
analgesia 33 99.96 Very High Very High Very High
GABAergic 28 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 7 100.00 Very High Very High Very High
Convulsion 65 99.84 Very High Very High Very High
Nociception 27 99.82 Very High Very High Very High
Pain 207 99.42 Very High Very High Very High
Epilepsy 9 99.16 Very High Very High Very High
Neurodegenerative Disease 6 98.92 Very High Very High Very High
Cancer 167 98.90 Very High Very High Very High
Body Weight 60 97.16 Very High Very High Very High
Targeted Disruption 65 96.88 Very High Very High Very High
Obesity 163 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: The high expression of the CCK gene in the brain can decrease body weight and increase plasma glucose.
Gene_expression (expression) of CCK gene in body
1) Confidence 0.78 Published 2009 Journal Chin. Med. J. Section Body Doc Link 19781389 Disease Relevance 0.06 Pain Relevance 0
CB1 is very highly coexpressed with CCK.
Gene_expression (coexpressed) of CCK associated with cholecystokinin
2) Confidence 0.74 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10594647 Disease Relevance 0 Pain Relevance 0.74
The group of ß-gal+ cells in this hindbrain area was localized within a region of CCK immunoreactivity and some, but not all, ß-gal+ cells appeared to express CCK (Fig. 5B).
Gene_expression (express) of CCK in hindbrain associated with cholecystokinin
3) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.34
Taken together with their rostral position, these data suggest that the group of Runx1-expressing neurons in the dorsolateral rostral hindbrain is located within the LPBS and at least a subset of these neurons likely express CCK but not Lmx1b.


Gene_expression (express) of CCK in neurons associated with cholecystokinin
4) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.33
The expression of PDGF-CCK was analyzed by Western blotting.
Spec (analyzed) Gene_expression (expression) of PDGF-CCK
5) Confidence 0.68 Published 2009 Journal Chin. Med. J. Section Body Doc Link 19781389 Disease Relevance 0.09 Pain Relevance 0
Sulfated cholecystokinin (CCK, from 0.05 to 0.5 ng) injected i.t. significantly reduced the inhibition of the tail-flick response induced by DSC (30 microg) administered i.t.
Gene_expression (injected) of CCK in tail associated with tail-flick and cholecystokinin
6) Confidence 0.68 Published 2000 Journal J Ethnopharmacol Section Abstract Doc Link 10904165 Disease Relevance 0 Pain Relevance 1.08
In contrast, 3R[+]-N-[2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-benzodiazepin-3-yl ]-N'- [3-methyl-phenyl]urea (L365,260), a selective CCKB receptor antagonist, blocked the action of CCK4(30-33) and SNF 9007 (phase I), and also antagonized CCK8(s), though to a lesser degree.
Gene_expression (antagonized) of CCK8 associated with antagonist
7) Confidence 0.68 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8113956 Disease Relevance 0 Pain Relevance 0.29
CCK8(s) and SNF 9007 (phase I) were active at low nanomolar concentrations, whereas CCK4(30-33) was active only at high nanomolar concentrations: the rank order of potencies to increase Isc was CCK8(s) > SNF 9007 > CCK4(30-33).
Gene_expression (active) of CCK8
8) Confidence 0.68 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8113956 Disease Relevance 0 Pain Relevance 0.50
Devazepide (L364,718), a selective antagonist of CCKA receptors, effectively blocked the action of CCK8(s), but not that of CCK4(30-33) or SNF 9007 (phase I).
Gene_expression (action) of CCK8 associated with antagonist
9) Confidence 0.68 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8113956 Disease Relevance 0 Pain Relevance 0.46
Four days after injections of 0.2 or 0.25 microgram kainic acid, mossy fiber ENK-I was greatly elevated, dynorphin immunoreactivity was reduced, but, unlike the situation with lower kainic acid doses, CCK-I was only modestly reduced in the mossy fibers and was clearly reduced in other hippocampal systems as well.
Gene_expression (reduced) of CCK-I in mossy fiber associated with dynorphin and cholecystokinin
10) Confidence 0.67 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2898512 Disease Relevance 0.07 Pain Relevance 0.50
In mice, intraperitoneally injected chlordiazepoxide and proglumide, both of which are regarded as cholecystokinin (CCK) receptor antagonists in the peripheral tissues, dose-dependently inhibited the satiety induced by 200 ng of intracisternally administered CCK octapeptide (CCK8).
Gene_expression (antagonists) of CCK associated with antagonist and cholecystokinin
11) Confidence 0.67 Published 1987 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2883334 Disease Relevance 0.08 Pain Relevance 0.41
Therefore, CCK receptors in brain may be involved in the apparent antinociception produced by CCK-8-U and CCK-4.
Gene_expression (produced) of CCK-4 in brain associated with antinociception
12) Confidence 0.67 Published 1986 Journal Neuropharmacology Section Abstract Doc Link 3774112 Disease Relevance 0.17 Pain Relevance 0.63
OBJECTIVE: The aim of the present work was to study the pain sensitivity, morphine-induced antinociception and density of opioid receptors in mice lacking CCK(2) receptors.
Neg (lacking) Gene_expression (lacking) of CCK
13) Confidence 0.67 Published 2003 Journal Psychopharmacology (Berl.) Section Body Doc Link 12545332 Disease Relevance 0.09 Pain Relevance 0
We did not find any of these changes in CCK(2) receptor-deficient homozygous mice.
Gene_expression (deficient) of CCK associated with cholecystokinin
14) Confidence 0.67 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18412633 Disease Relevance 0.32 Pain Relevance 1.27
In contrast, 3R[+]-N-[2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-benzodiazepin-3-yl ]-N'- [3-methyl-phenyl]urea (L365,260), a selective CCKB receptor antagonist, blocked the action of CCK4(30-33) and SNF 9007 (phase I), and also antagonized CCK8(s), though to a lesser degree.
Gene_expression (antagonist) of CCK associated with antagonist
15) Confidence 0.65 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8113956 Disease Relevance 0 Pain Relevance 0.31
Altered pain sensitivity and morphine-induced anti-nociception in mice lacking CCK2 receptors.
Neg (lacking) Gene_expression (lacking) of CCK associated with nociception, pain and morphine
16) Confidence 0.65 Published 2003 Journal Psychopharmacology (Berl.) Section Title Doc Link 12545332 Disease Relevance 0.20 Pain Relevance 0.34
Cholecystokinin octapeptide (CCK-8), caerulein and seven out of ten analogues of caerulein produced in mice, after subcutaneous administration, a dose-dependent drop in rectal temperature.
Gene_expression (produced) of Cholecystokinin associated with cholecystokinin
17) Confidence 0.65 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6289160 Disease Relevance 0 Pain Relevance 0.30
Experiment 2 Individual and combined administration of CCK receptor antagonists and CART(61-102)
Gene_expression (antagonists) of CCK associated with antagonist and cholecystokinin
18) Confidence 0.64 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0 Pain Relevance 0.18
g/kg determined in a preliminary study), unlike fasted outbred NMRI mice that were sensitive to CCK-8 dose of 4 ?
Gene_expression (dose) of CCK-8 associated with cholecystokinin
19) Confidence 0.64 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0 Pain Relevance 0.55
Fos immunoreactivity in NTS, PVN, and DMH after CART peptide and CCK administration
Gene_expression (administration) of CCK associated with medulla and cholecystokinin
20) Confidence 0.64 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0 Pain Relevance 0.54

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