INT97960

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Context Info
Confidence 0.11
First Reported 2001
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.09
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ST3GAL3) Golgi apparatus (ST3GAL3)
Anatomy Link Frequency
endothelial cells 1
ST3GAL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 7 99.98 Very High Very High Very High
COX2 2 99.86 Very High Very High Very High
antagonist 3 88.64 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 99.38 Very High Very High Very High
Necrosis 1 97.12 Very High Very High Very High
Cancer 19 96.94 Very High Very High Very High
Adhesions 2 88.88 High High
Apoptosis 1 84.48 Quite High
Metastasis 1 69.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis.
Negative_regulation (inhibit) of alpha V beta 3 associated with cinod
1) Confidence 0.11 Published 2001 Journal Nat. Med. Section Title Doc Link 11533708 Disease Relevance 0.68 Pain Relevance 0.54
Selective disruption of the tumor vasculature by high doses of tumor necrosis factor (TNF) and interferon gamma (IFN-gamma), and the antiangiogenic activity of nonsteroidal anti-inflammatory drugs are associated with the suppression of integrin alpha V beta 3 function and signaling in endothelial cells.
Negative_regulation (suppression) of alpha V beta 3 in endothelial cells associated with necrosis, inflammation, cancer and cinod
2) Confidence 0.11 Published 2002 Journal Endothelium Section Abstract Doc Link 12380640 Disease Relevance 1.41 Pain Relevance 0.22

General Comments

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