INT9797

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Context Info
Confidence 0.48
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 1.14
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Homer1) cytoplasm (Homer1)
Homer1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 5 100.00 Very High Very High Very High
TRP channel 5 99.32 Very High Very High Very High
Glutamate receptor 10 91.96 High High
addiction 5 89.52 High High
Hippocampus 45 80.04 Quite High
amygdala 13 75.60 Quite High
midbrain 2 75.00 Quite High
lidocaine 1 43.84 Quite Low
Pyramidal cell 15 5.00 Very Low Very Low Very Low
Immobilon 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 5 88.00 High High
Convulsion 10 84.28 Quite High
Urological Neuroanatomy 5 83.04 Quite High
Infection 5 80.48 Quite High
Anxiety Disorder 145 57.28 Quite High
Targeted Disruption 20 55.52 Quite High
Shock 75 5.00 Very Low Very Low Very Low
Diphtheria 5 5.00 Very Low Very Low Very Low
Congenital Anomalies 5 5.00 Very Low Very Low Very Low
Nociception 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vesl-1L/Homer1c contains additional C-terminal sequences, which include a coiled-coil domain and a leucine zipper, via which they associate to form homo- and heteromultimers to function as a scaffold protein and interact with receptors [11,12,14].
Homer1c Binding (interact) of
1) Confidence 0.48 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.20 Pain Relevance 0.15
Vesl-1L/Homer1c contains additional C-terminal sequences, which include a coiled-coil domain and a leucine zipper, via which they associate to form homo- and heteromultimers to function as a scaffold protein and interact with receptors [11,12,14].
Vesl-1L Binding (interact) of
2) Confidence 0.48 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.20 Pain Relevance 0.15
Although the short forms of the Vesl protein contain the EVH-1 domain, they lack the C-terminal coiled-coil domain; therefore, the inducible short form Vesl-1 proteins are believed to act as endogenous dominant-negative regulators, as they compete with the long form Vesl protein to bind to receptors and channels.
Vesl protein Binding (bind) of
3) Confidence 0.42 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.23 Pain Relevance 0.16
Furthermore, binding to Vesl directly modulates the antagonist-independent activity of mGluRs [43], thus, the KO of the short form of Vesl-1 may lead to improper regulation of synaptic mGluR function, which in turn disturbs the establishment of L-LTP.
Vesl-1 Binding (binding) of associated with antagonist
4) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.11 Pain Relevance 0.09
Immunocytochemical methods were used to localize the protein product of the immediate-early gene, c-fos, in male rats after exposure to, or direct physical interaction with, oestrous females.
immediate-early gene Binding (interaction) of
5) Confidence 0.35 Published 1992 Journal Neuroscience Section Abstract Doc Link 1436507 Disease Relevance 0.16 Pain Relevance 0.18
Although the short forms of the Vesl protein contain the EVH-1 domain, they lack the C-terminal coiled-coil domain; therefore, the inducible short form Vesl-1 proteins are believed to act as endogenous dominant-negative regulators, as they compete with the long form Vesl protein to bind to receptors and channels.
Vesl-1 Binding (bind) of
6) Confidence 0.31 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.24 Pain Relevance 0.16

General Comments

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