INT97973

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2009
Negated 2
Speculated 1
Reported most in Body
Documents 24
Total Number 27
Disease Relevance 30.95
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (XRCC1) nucleus (XRCC1) intracellular (XRCC1)
Anatomy Link Frequency
kidney 2
skin 1
cell component 1
duct 1
XRCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 39 99.64 Very High Very High Very High
imagery 39 99.16 Very High Very High Very High
COX-2 inhibitor 24 98.76 Very High Very High Very High
Analgesic 27 95.68 Very High Very High Very High
spinal inflammation 12 95.68 Very High Very High Very High
Paracetamol 18 94.84 High High
aspirin 9 91.16 High High
Central nervous system 21 90.56 High High
Pain 4 87.60 High High
backache 5 85.28 High High
Disease Link Frequency Relevance Heat
Renal Cancer 1290 100.00 Very High Very High Very High
Cancer 851 100.00 Very High Very High Very High
Carcinoma 143 100.00 Very High Very High Very High
Renal Cell Carcinoma 52 100.00 Very High Very High Very High
Syndrome 139 99.92 Very High Very High Very High
Nicotine Addiction 66 99.84 Very High Very High Very High
Viral Infection 6 99.84 Very High Very High Very High
INFLAMMATION 14 99.36 Very High Very High Very High
Metastasis 155 99.26 Very High Very High Very High
Cv Unclassified Under Development 60 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
coffee consumption does not increase RCC risk.
Neg (not) Positive_regulation (increase) of RCC associated with renal cancer
1) Confidence 0.40 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581742 Disease Relevance 1.06 Pain Relevance 0.06
Having a first and/or second-degree relative with kidney cancer was similarly associated with an increased risk of RCC (OR, 2.9; 95% CI, 1.4-6.3).
Positive_regulation (increased) of RCC in kidney associated with renal cancer
2) Confidence 0.38 Published 2001 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 11535554 Disease Relevance 1.66 Pain Relevance 0.09
On the other hand, the XRCC1 gene is important in DNA base excision repair.
Positive_regulation (important) of XRCC1
3) Confidence 0.37 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.45 Pain Relevance 0.06
A high incidence of RCC in smokers
Positive_regulation (incidence) of RCC associated with nicotine addiction and renal cancer
4) Confidence 0.29 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581742 Disease Relevance 1.12 Pain Relevance 0
oestrogens can induce RCC in the animal model, little evidence supports an
Positive_regulation (induce) of RCC associated with renal cancer
5) Confidence 0.27 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581742 Disease Relevance 1.36 Pain Relevance 0.54
radiation appears to increase the RCC risk slightly, especially among patients
Spec (appears) Positive_regulation (increase) of RCC associated with renal cancer
6) Confidence 0.27 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581742 Disease Relevance 1.29 Pain Relevance 0.18
Smoking, chemical carcinogens like asbestos or organic solvents are some of these factors that increase the risk of the RCC.
Positive_regulation (increase) of RCC associated with nicotine addiction and renal cancer
7) Confidence 0.27 Published 2008 Journal Advances in Urology Section Abstract Doc Link PMC2581742 Disease Relevance 1.30 Pain Relevance 0
or CT scan, and not due to a real increased incidence of RCC.
Positive_regulation (increased) of RCC associated with renal cancer
8) Confidence 0.27 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581742 Disease Relevance 1.07 Pain Relevance 0
In the pathogenesis of conventional RCC, mutations leading to
Positive_regulation (leading) of RCC associated with renal cancer
9) Confidence 0.26 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2467459 Disease Relevance 1.04 Pain Relevance 0.03
Most of the kidney masses are being detected
                 incidentally with smaller size due to widespread use of imaging modalities leading 
                 to increased RCC incidence worldwide with an earlier stage. 
Positive_regulation (increased) of RCC in kidney associated with imagery
10) Confidence 0.24 Published 2008 Journal Advances in Urology Section Abstract Doc Link PMC2467459 Disease Relevance 0.07 Pain Relevance 0.05
This gene may be a potential tumor suppressor protein for RCC as well.
Positive_regulation (potential) of RCC associated with cancer and renal cancer
11) Confidence 0.20 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.86 Pain Relevance 0
Carbonic anhydrase IX (CAIX) expression is HIF dependent and its expression is increased in VHL mutated RCC.
Positive_regulation (increased) of RCC associated with renal cancer
12) Confidence 0.17 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667482 Disease Relevance 0.70 Pain Relevance 0
Local excision is a safe treatment for small RCC,
Positive_regulation (treatment) of RCC associated with carcinoma
13) Confidence 0.17 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2629071 Disease Relevance 1.08 Pain Relevance 0
Aggressive potential of small RCC could increase in tumors greater than 3 cm, so it is suggested that
Positive_regulation (increase) of RCC associated with cancer and carcinoma
14) Confidence 0.15 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2629071 Disease Relevance 1.07 Pain Relevance 0
Nonsteroidal antiinflammatory drugs (NSAIDs) have anticancer effects for the RCC patient, thus, attracting a great deal of attention.
Positive_regulation (effects) of RCC associated with inflammation, renal cancer and cinod
15) Confidence 0.08 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994214 Disease Relevance 0.99 Pain Relevance 0.55
In conclusion, COX-2 expression is strong in RCC, but the anticancer effect of COX-2 inhibitor is very weak in RCC patients in a single administration at a clinical dose.
Positive_regulation (strong) of RCC associated with renal cancer and cox-2 inhibitor
16) Confidence 0.08 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994214 Disease Relevance 1.26 Pain Relevance 0.27
Mungan and colleagues (2006) reported COX-2 expression was significantly higher in RCC and renal intratubular neoplasia than the normal and pyelonephritic cases by immunohistochemisty.
Positive_regulation (higher) of RCC associated with cancer and renal cancer
17) Confidence 0.08 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994214 Disease Relevance 1.26 Pain Relevance 0
thought to be sporadic whereas there has been estimated that hereditary RCC
Positive_regulation (estimated) of RCC
18) Confidence 0.08 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.50 Pain Relevance 0.13
Herein is presented a case of RCC possessing the chromophobe RCC and CDC elements occurring in a 64 year-old Japanese woman.
Positive_regulation (presented) of RCC associated with carcinoma and renal cell carcinoma
19) Confidence 0.07 Published 2005 Journal Pathol. Int. Section Abstract Doc Link 15943794 Disease Relevance 1.43 Pain Relevance 0.12
elucidated, leading to a model of how disruption of the VHL gene results in RCC and
Positive_regulation (results) of RCC
20) Confidence 0.07 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.97 Pain Relevance 0

General Comments

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