INT9798

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Context Info
Confidence 0.41
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 2.04
Pain Relevance 3.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Homer1) cytoplasm (Homer1)
Anatomy Link Frequency
neuronal 4
dorsal 2
brain 2
brainstem 2
cerebellum 2
Homer1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 1 100.00 Very High Very High Very High
dopamine receptor 1 99.66 Very High Very High Very High
antagonist 6 99.56 Very High Very High Very High
medulla 6 99.16 Very High Very High Very High
Raphe 6 99.12 Very High Very High Very High
Glutamate 3 98.12 Very High Very High Very High
parabrachial 1 98.08 Very High Very High Very High
Botox 11 96.36 Very High Very High Very High
long-term potentiation 45 95.36 Very High Very High Very High
Enkephalin 4 95.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pseudorabies 10 100.00 Very High Very High Very High
Targeted Disruption 13 99.88 Very High Very High Very High
Ataxia 3 96.68 Very High Very High Very High
Hyperphagia 1 87.04 High High
Cognitive Disorder 19 84.76 Quite High
Headache 5 84.16 Quite High
Anxiety Disorder 43 82.60 Quite High
Urological Neuroanatomy 5 77.36 Quite High
Pain 7 75.00 Quite High
Muscular Spasm 1 63.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of the immediate early gene, c-fos, was used to determine the distribution of brainstem neurons activated by stimulation of the distal hypoglossal nerve (XIIn) trunk.
Spec (determine) Negative_regulation (determine) of Gene_expression (expression) of immediate early gene in brainstem associated with medulla
1) Confidence 0.41 Published 2000 Journal Somatosens Mot Res Section Abstract Doc Link 10994593 Disease Relevance 0 Pain Relevance 0.08
Previously, we showed that unilateral blockade of D1 dopamine receptors in the striatum inhibits immediate-early gene expression bilaterally throughout large parts of the cortex, including sensory-evoked expression in the barrel cortex.
Negative_regulation (inhibits) of in cortex Gene_expression (expression) of immediate-early gene in barrel cortex associated with dopamine receptor
2) Confidence 0.41 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11703467 Disease Relevance 0 Pain Relevance 0.21
Immunocytochemical methods were used to localize the protein product of the immediate-early gene, c-fos, in male rats after exposure to, or direct physical interaction with, oestrous females.
Negative_regulation (localize) of Gene_expression (product) of immediate-early gene
3) Confidence 0.41 Published 1992 Journal Neuroscience Section Abstract Doc Link 1436507 Disease Relevance 0.15 Pain Relevance 0.17
Immediate early gene expression is normal in GluR2-cKO mice
Negative_regulation (is) of Gene_expression (expression) of Immediate early gene
4) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.30 Pain Relevance 0.16
Motor-Coordination-Dependent Learning, More than Others, Is Impaired in Transgenic Mice Expressing Pseudorabies Virus Immediate-Early Protein IE180

The cerebellum in transgenic mice expressing pseudorabies virus immediate-early protein IE180 (TgIE96) was substantially diminished in size, and its histoarchitecture was severely disorganized, resulting in severe ataxia.

Negative_regulation (diminished) of Gene_expression (expressing) of immediate-early protein in cerebellum associated with targeted disruption, ataxia and pseudorabies
5) Confidence 0.11 Published 2010 Journal PLoS ONE Section Title Doc Link PMC2920824 Disease Relevance 0.79 Pain Relevance 0
The stimulatory effect of the MS extract was determined by detecting the expression of the immediate early gene, cfos, in the dorsal raphe nucleus of male Wistar rats.
Negative_regulation (detecting) of Gene_expression (expression) of immediate early gene in dorsal associated with raphe
6) Confidence 0.07 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17316993 Disease Relevance 0 Pain Relevance 0.30
The activity-dependent immediate early gene protein Krox-24, expressed in the neocortex at high basal levels, decreases rapidly upon neuronal deactivation (Chaudhuri et al. [1995] Vis.
Negative_regulation (decreases) of Gene_expression (expressed) of immediate early gene protein Krox-24 in neuronal
7) Confidence 0.07 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9520106 Disease Relevance 0 Pain Relevance 0.06
In Experiment 2, detection of the expression of the immediate early gene, c-fos, was used to examine brain areas activated following intra-striatal microinfusion of D-Ala(2), NMe-Phe(4),Glyol(5)-enkephalin.
Negative_regulation (detection) of Gene_expression (expression) of immediate early gene in brain associated with enkephalin
8) Confidence 0.03 Published 2000 Journal Neuroscience Section Abstract Doc Link 10938432 Disease Relevance 0.09 Pain Relevance 0.71
Regionally, CREB was dephosphorylated wherever immediate-early gene expression went up.
Negative_regulation (wherever) of Gene_expression (expression) of immediate-early gene
9) Confidence 0.02 Published 2002 Journal Exp. Neurol. Section Abstract Doc Link 12009775 Disease Relevance 0 Pain Relevance 0.16
The non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) attenuates morphine-induced immediate-early gene expression in the rat striatum in a sexually dimorphic manner that depends in part on gonadal steroids.
Negative_regulation (attenuates) of in striatum Gene_expression (expression) of immediate-early gene in gonadal associated with antagonist and morphine
10) Confidence 0.01 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 12464400 Disease Relevance 0 Pain Relevance 0.33
Furthermore, Fos, a product of the immediate early gene, c-fos, expressed with neuronal stimuli was prevented upon peripheral exposure to the toxin.
Negative_regulation (prevented) of Gene_expression (expressed) of early gene in neuronal
11) Confidence 0.00 Published 2003 Journal Headache Section Abstract Doc Link 12887389 Disease Relevance 0.71 Pain Relevance 1.59

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