INT97985

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2001
Last Reported 2008
Negated 4
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.15
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Kcna3)
Kcna3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 15 99.82 Very High Very High Very High
Glutamate receptor 2 93.84 High High
addiction 3 88.08 High High
tetrodotoxin 2 87.36 High High
Action potential 2 80.12 Quite High
potassium channel 3 75.52 Quite High
GABAergic 2 65.92 Quite High
Serotonin 1 61.04 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 2 84.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fluoxetine did not affect the ion selectivity of Kv3.1.
Neg (not) Regulation (affect) of Kv3 associated with fluoxetine
1) Confidence 0.45 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18187934 Disease Relevance 0 Pain Relevance 0.90
Norfluoxetine did not affect the ion selectivity of Kv3.1.
Neg (not) Regulation (affect) of Kv3
2) Confidence 0.45 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11543764 Disease Relevance 0 Pain Relevance 0.36
Kv3 protein levels were not changed by exogenous tropomyosin-related kinase B (TrkB) ligands, but the levels decreased upon inhibiting the MAPK signaling suggesting a role for endogenous factors and in particular MEK2 signaling for translation.
Neg (not) Regulation (changed) of Kv3
3) Confidence 0.20 Published 2008 Journal Neuroscience Section Abstract Doc Link 18775767 Disease Relevance 0.06 Pain Relevance 0.19
However, chronic activity deprivation failed to alter Kv3.1b and marginally delayed Kv3.2 protein expression.
Neg (failed) Regulation (alter) of Kv3
4) Confidence 0.12 Published 2008 Journal Neuroscience Section Abstract Doc Link 18775767 Disease Relevance 0.08 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox