INT97994

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Context Info
Confidence 0.32
First Reported 2001
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.98
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hmox2) endoplasmic reticulum (Hmox2) plasma membrane (Hmox2)
Anatomy Link Frequency
margin 1
cardiovascular systems 1
liver 1
Hmox2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 50 99.36 Very High Very High Very High
Inflammation 4 99.12 Very High Very High Very High
withdrawal 3 98.88 Very High Very High Very High
Arthritis 5 97.90 Very High Very High Very High
diclofenac 22 97.70 Very High Very High Very High
COX-2 inhibitor 2 94.24 High High
aspirin 15 78.16 Quite High
cva 2 64.08 Quite High
COX2 3 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 33 99.12 Very High Very High Very High
Injury 1 97.96 Very High Very High Very High
Arthritis 5 97.90 Very High Very High Very High
Myocardial Infarction 47 96.96 Very High Very High Very High
Pressure And Volume Under Development 2 96.32 Very High Very High Very High
Acute Liver Failure 1 94.96 High High
Low Back Pain 1 92.92 High High
Thrombosis 1 92.16 High High
Hepatotoxicity 3 86.72 High High
Toxicity 6 85.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, physiological roles for cyclo-oxygenase-2 both in the renal and cardiovascular systems are becoming better recognized.
cyclo-oxygenase-2 Binding (recognized) of in cardiovascular systems
1) Confidence 0.32 Published 2001 Journal Dig Liver Dis Section Abstract Doc Link 11827359 Disease Relevance 0.77 Pain Relevance 0.17
Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which preferentially inhibits cyclo-oxygenase 2 and has been associated with a total of 13 reported cases of severe liver injury including our case.
cyclo-oxygenase 2 Binding (associated) of in liver associated with inflammation, injury and cinod
2) Confidence 0.31 Published 2001 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 11549211 Disease Relevance 0.68 Pain Relevance 0.20
We prespecified a rate ratio of 1.3 as the primary threshold, which was used as non-inferiority margin in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme.16 We used linear regression to test for each outcome whether there was any association with cyclo-oxygenase-2 selectivity (data only shown in web extra appendix 2).
cyclo-oxygenase-2 Binding (association) of in margin associated with diclofenac and arthritis
3) Confidence 0.06 Published 2011 Journal BMJ : British Medical Journal Section Body Doc Link PMC3019238 Disease Relevance 0.10 Pain Relevance 0.10
The recent withdrawal of rofecoxib together with new data showing that other cyclo-oxygenase-2 (COX-2) inhibitors might also be associated with an increased risk of developing adverse cardiovascular events, mainly acute myocardial infarction (MI), has created a climate of uncertainty surrounding the safety of these drugs and traditional non-steroidal anti-inflammatory drugs (tNSAIDs) [1,2].
cyclo-oxygenase-2 Spec (might) Binding (associated) of associated with inflammation, cinod, withdrawal and myocardial infarction
4) Confidence 0.01 Published 2005 Journal BMC Med Section Body Doc Link PMC1310534 Disease Relevance 0.44 Pain Relevance 0.17
OBJECTIVE: Cyclo-oxygenase-2 (COX-2) inhibitors rofecoxib and valdecoxib were withdrawn from the market because of their association with cardiovascular problems.
Cyclo-oxygenase-2 Binding (association) of
5) Confidence 0.01 Published 2007 Journal Curr Med Res Opin Section Abstract Doc Link 17605893 Disease Relevance 0 Pain Relevance 0.40

General Comments

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