INT9801

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Context Info
Confidence 0.45
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.40
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (TTR) extracellular space (TTR) extracellular region (TTR)
cytoplasm (TTR)
Anatomy Link Frequency
liver 1
TTR (Homo sapiens)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 5 94.24 High High
diclofenac 6 62.88 Quite High
cINOD 14 58.28 Quite High
Central nervous system 2 12.40 Low Low
Inflammation 13 5.00 Very Low Very Low Very Low
cOX1 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Gabapentin 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 13 96.76 Very High Very High Very High
Carpal Tunnel Syndrome 5 94.24 High High
Restrictive Cardiomyopathy 5 94.16 High High
Neuropathy 4 91.96 High High
Neuropathic Pain 2 91.04 High High
Rare Diseases 1 89.88 High High
Familial Amyloidotic Polyneuropathy 32 88.04 High High
INFLAMMATION 15 57.72 Quite High
Alzheimer's Dementia 45 50.00 Quite Low
Heart Rate Under Development 2 42.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most common hereditary amyloidogenic protein, transthyretin, is synthesized in the liver and lies on Chromosome 18.
Regulation (lies) of transthyretin in liver
1) Confidence 0.45 Published 2008 Journal J Med Case Reports Section Abstract Doc Link PMC2248590 Disease Relevance 0.84 Pain Relevance 0
Affected subjects were heterozygous for a novel mutation in serum transthyretin (TTR), resulting in an asparagine for lysine substitution at residue 70 of the TTR monomer.
Regulation (heterozygous) of TTR
2) Confidence 0.44 Published 1992 Journal Neurology Section Abstract Doc Link 1436517 Disease Relevance 0.50 Pain Relevance 0.34
Six halogen binding pockets (HBP1, HBP1', HBP2, HBP2', HBP3 and HBP3') were also defined within each hormone binding pocket based on the positions of the halogen atoms of T4 in the TTR?
Regulation (positions) of TTR
3) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709434 Disease Relevance 0.06 Pain Relevance 0.15
Based on the inhibitor efficacy data of aryl compounds 22, 23, 24, 28, 29, and 31 it is clear that further lengthening of the linker affects TTR fibril formation.
Regulation (affects) of TTR
4) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709434 Disease Relevance 0 Pain Relevance 0

General Comments

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