INT9801

Context Info Confidence 0.45 First Reported 1992 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 1.40 Pain Relevance 0.48

transport (TTR) extracellular space (TTR) extracellular region (TTR) cytoplasm (TTR)

Anatomy Link Frequency liver 1 TTR (Homo sapiens)

Pain Link Frequency Relevance Heat carpal tunnel syndrome 5 94.24 diclofenac 6 62.88 cINOD 14 58.28 Central nervous system 2 12.40 Inflammation 13 5.00 cOX1 2 5.00 Potency 2 5.00 Pain 1 5.00 Gabapentin 1 5.00 peripheral neuropathy 1 5.00

Disease Link Frequency Relevance Heat Disease 13 96.76 Carpal Tunnel Syndrome 5 94.24 Restrictive Cardiomyopathy 5 94.16 Neuropathy 4 91.96 Neuropathic Pain 2 91.04 Rare Diseases 1 89.88 Familial Amyloidotic Polyneuropathy 32 88.04 INFLAMMATION 15 57.72 Alzheimer's Dementia 45 50.00 Heart Rate Under Development 2 42.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The most common hereditary amyloidogenic protein, transthyretin, is synthesized in the liver and lies on Chromosome 18.

Regulation (lies) of transthyretin in liver

1) Confidence 0.45 Published 2008 Journal J Med Case Reports Section Abstract Doc Link PMC2248590 Disease Relevance 0.84 Pain Relevance 0

Affected subjects were heterozygous for a novel mutation in serum transthyretin (TTR), resulting in an asparagine for lysine substitution at residue 70 of the TTR monomer.

Regulation (heterozygous) of TTR

2) Confidence 0.44 Published 1992 Journal Neurology Section Abstract Doc Link 1436517 Disease Relevance 0.50 Pain Relevance 0.34

Six halogen binding pockets (HBP1, HBP1', HBP2, HBP2', HBP3 and HBP3') were also defined within each hormone binding pocket based on the positions of the halogen atoms of T4 in the TTR?

Regulation (positions) of TTR

3) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709434 Disease Relevance 0.06 Pain Relevance 0.15

Based on the inhibitor efficacy data of aryl compounds 22, 23, 24, 28, 29, and 31 it is clear that further lengthening of the linker affects TTR fibril formation.

Regulation (affects) of TTR

4) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709434 Disease Relevance 0 Pain Relevance 0

General Comments

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