INT98016

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Context Info
Confidence 0.18
First Reported 2001
Last Reported 2005
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.07
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pth)
Anatomy Link Frequency
proximal 2
parathyroid 1
Pth (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 1 91.44 High High
Hippocampus 3 60.64 Quite High
fibrosis 21 9.44 Low Low
gABA 12 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
fluoxetine 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
medulla 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Hypophosphatemia 3 94.52 High High
Kidney Stones 6 93.64 High High
Hypophosphatemia 5 92.84 High High
Osteoporosis 1 86.96 High High
Nephrocalcinosis 3 85.88 High High
Renal Failure 3 85.00 Quite High
Targeted Disruption 18 81.12 Quite High
Congenital Anomalies 6 45.36 Quite Low
Kyphosis 3 32.40 Quite Low
Pressure And Volume Under Development 24 27.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, several proteins, such as parathyroid hormone (PTH) and micromolecular proteins are not degraded in the proximal tubules.
Neg (not) Protein_catabolism (degraded) of PTH in proximal
1) Confidence 0.18 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792346 Disease Relevance 0.56 Pain Relevance 0.03
Lack of degradation of megalin and PTH in mice lacking ClC-5 is believed to lead to a high luminal concentration of these calcitropic proteins, resulting in microalbuminuria, hyperphosphaturia and hypercalciuria [93].
Protein_catabolism (degradation) of PTH associated with familial hypophosphatemia and kidney stones
2) Confidence 0.18 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792346 Disease Relevance 0.59 Pain Relevance 0.03
Similarly, several proteins, such as parathyroid hormone (PTH) and micromolecular proteins are not degraded in the proximal tubules.
Neg (not) Protein_catabolism (degraded) of parathyroid hormone in proximal
3) Confidence 0.16 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792346 Disease Relevance 0.56 Pain Relevance 0.03
In addition, membranes expressing rPhex-WT, rPhex-3'M, and the empty vector hydrolyzed parathyroid hormone-(1-34), indicating the lack of Phex-specific cleavage of parathyroid hormone.
Protein_catabolism (cleavage) of parathyroid hormone in parathyroid
4) Confidence 0.09 Published 2001 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 11551862 Disease Relevance 0.37 Pain Relevance 0.09

General Comments

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