INT98017

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Context Info
Confidence 0.11
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.16
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
myoblast 1
muscle 1
cartilage 1
osteoblast 1
thymus 1
Gtf3a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 134 97.16 Very High Very High Very High
Snapping jaw 1 94.92 High High
Central nervous system 51 94.04 High High
cytokine 116 87.12 High High
Enkephalin 1 75.68 Quite High
cva 1 45.80 Quite Low
Dopamine 61 25.28 Quite Low
addiction 1 18.88 Low Low
Multiple sclerosis 160 5.00 Very Low Very Low Very Low
imagery 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 44 100.00 Very High Very High Very High
Hypophosphatemia 5 100.00 Very High Very High Very High
Osteoporosis 5 99.40 Very High Very High Very High
Hypoxia 45 99.24 Very High Very High Very High
Pulmonary Disease 196 98.60 Very High Very High Very High
Wallerian Degeneration 174 98.58 Very High Very High Very High
INFLAMMATION 161 97.16 Very High Very High Very High
Stress 54 97.08 Very High Very High Very High
Injury 47 96.74 Very High Very High Very High
Apoptosis 40 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transforming growth factor-beta (TGF-beta), is a multifactorial growth factor affecting matrix synthesis and cell proliferation in bone and cartilage, whereas interleukin-1 (IL-1) is involved in cartilage degradation.
Protein_catabolism (degradation) of factor in cartilage
1) Confidence 0.11 Published 1997 Journal Arch Gerontol Geriatr Section Abstract Doc Link 15374127 Disease Relevance 0.28 Pain Relevance 0.09
Second, the growth factors can be released in a controlled, sequenced, and time-dependent manner by controlled growth factor diffusion, polymer degradation, and the composition of the polymer.
Protein_catabolism (degradation) of factor
2) Confidence 0.03 Published 2009 Journal Pharm Res Section Body Doc Link PMC2812420 Disease Relevance 0.42 Pain Relevance 0
Neither casein, a substrate for the related endopeptidase thermolysin, human stanniocalcin 1 (hSTC-1), an osteoblast-derived phosphate-regulating factor, nor FGF-23 peptide (amino acid 172-186), comprising the region mutated in autosomal dominant hypophosphatemia, was cleaved by rPhex-WT.
Protein_catabolism (cleaved) of factor in osteoblast associated with hypophosphatemia and osteoporosis
3) Confidence 0.01 Published 2001 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 11551862 Disease Relevance 0.42 Pain Relevance 0.08
trigger the phosphorylation and degradation of the inhibitory factor, I?
Protein_catabolism (degradation) of factor
4) Confidence 0.01 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.56 Pain Relevance 0.41
Some of these findings were demonstrated in a model accounting for the degradation of the NRF2 transcription factor by CRIF1 and KEAP1 (see Fig. 9 and its legend).
Protein_catabolism (degradation) of factor
5) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.33 Pain Relevance 0
We reasoned that depletion should trigger Wallerian-like degeneration without injury, its natural half-life should be consistent with the latent phase of Wallerian degeneration (WldS should be much more stable to extend this period), the survival factor should be degraded by the proteasome to explain why proteasome inhibition extends axonal survival, it should be present in axons, and it should significantly prolong injured axon survival when highly overexpressed (to outweigh its short half-life).
Protein_catabolism (degraded) of factor associated with injury and wallerian degeneration
6) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.35 Pain Relevance 0
The critical rate-limiting factor following translation inhibition is protein half-life, but for siRNA-mediated knock-down additional time is needed for mRNA degradation.
Protein_catabolism (degradation) of factor associated with targeted disruption
7) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2811159 Disease Relevance 0.65 Pain Relevance 0
Dicer facilitates, in a cell-autonomous fashion, the development of Treg cells in the thymus and the efficient induction of Foxp3 by transforming growth factor-beta (TGF-?).
Protein_catabolism (growth) of factor in thymus
8) Confidence 0.01 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.05 Pain Relevance 0.03
In addition, it has been reported in cell culture studies that hypoxia inhibits myoblast differentiation by degradation of MyoD, a myogenic transcription factor, via the ubiquitin proteasome pathway (Di Carlo et al 2004).
Protein_catabolism (degradation) of factor in myoblast associated with hypoxia
9) Confidence 0.01 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695204 Disease Relevance 1.42 Pain Relevance 0.08
However, it might well be that an impaired regenerative potential of the muscle rather than the increased protein degradation is the crucial factor in the loss of muscle mass during COPD with a high degree of systemic inflammation.
Protein_catabolism (degradation) of factor in muscle associated with pulmonary disease and inflammation
10) Confidence 0.01 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Abstract Doc Link PMC2695204 Disease Relevance 1.68 Pain Relevance 0.14

General Comments

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