INT98018

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Context Info
Confidence 0.65
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.58
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (FGF23) extracellular space (FGF23) extracellular region (FGF23)
Anatomy Link Frequency
osteoblast 1
cleavage 1
FGF23 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 1 96.24 Very High Very High Very High
Enkephalin 1 75.68 Quite High
Disease Link Frequency Relevance Heat
Hypophosphatemia 6 100.00 Very High Very High Very High
Osteoporosis 2 99.24 Very High Very High Very High
Fatigue 1 96.76 Very High Very High Very High
Arthralgia 1 96.24 Very High Very High Very High
Rickets 7 94.28 High High
Congenital Anomalies 1 93.08 High High
Syndrome 1 91.52 High High
Rare Diseases 1 85.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is caused by mutations in a consensus sequence for proteolytic cleavage of the FGF23 protein.
Protein_catabolism (cleavage) of FGF23 protein in cleavage
1) Confidence 0.65 Published 2010 Journal J. Bone Miner. Metab. Section Abstract Doc Link 19655082 Disease Relevance 1.16 Pain Relevance 0.10
Neither casein, a substrate for the related endopeptidase thermolysin, human stanniocalcin 1 (hSTC-1), an osteoblast-derived phosphate-regulating factor, nor FGF-23 peptide (amino acid 172-186), comprising the region mutated in autosomal dominant hypophosphatemia, was cleaved by rPhex-WT.
Protein_catabolism (cleaved) of nor FGF-23 peptide in osteoblast associated with hypophosphatemia and osteoporosis
2) Confidence 0.05 Published 2001 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 11551862 Disease Relevance 0.42 Pain Relevance 0.08

General Comments

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