INT9802

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Context Info
Confidence 0.60
First Reported 1989
Last Reported 2008
Negated 0
Speculated 5
Reported most in Abstract
Documents 9
Total Number 15
Disease Relevance 3.69
Pain Relevance 7.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Mtr) intracellular (Mtr) cytoplasm (Mtr)
Anatomy Link Frequency
plasma 6
liver 2
grey matter 1
cerebrospinal fluid 1
optic nerve 1
Mtr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 61 100.00 Very High Very High Very High
methotrexate 14 99.76 Very High Very High Very High
narcan 5 99.20 Very High Very High Very High
Morphine 10 97.68 Very High Very High Very High
Multiple sclerosis 6 97.48 Very High Very High Very High
Opioid 1 95.12 Very High Very High Very High
Neuritis 7 94.00 High High
alcohol 12 93.68 High High
anesthesia 5 91.80 High High
isoflurane 1 91.36 High High
Disease Link Frequency Relevance Heat
Congenital Anomalies 3 99.96 Very High Very High Very High
Drug-induced Liver Injury 24 99.32 Very High Very High Very High
Hepatotoxicity 4 98.52 Very High Very High Very High
Demyelinating Disease 10 97.48 Very High Very High Very High
Cancer 1 94.20 High High
Optic Neuritis 7 94.00 High High
Breast Cancer 1 93.40 High High
Toxicity 13 86.48 High High
Body Weight 1 66.56 Quite High
Diarrhoea 1 61.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thioacetamide treatment was associated with an 8.7-fold increase in plasma immunoreactive methionine enkephalin levels (P less than or equal to 0.005) 24 h after treatment.
Positive_regulation (increase) of methionine enkephalin in plasma associated with enkephalin
1) Confidence 0.60 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1436641 Disease Relevance 0.26 Pain Relevance 0.69
Potential mechanisms for this include trans-synaptic neuronal degeneration and cortical synaptic morphological changes; such abnormalities may also contribute to MTR abnormalities observed in the normal appearing grey matter in multiple sclerosis.
Spec (may) Positive_regulation (contribute) of MTR in grey matter associated with multiple sclerosis and congenital anomalies
2) Confidence 0.43 Published 2006 Journal Brain Section Abstract Doc Link 16495327 Disease Relevance 0.72 Pain Relevance 0.42
However, this marked elevation in plasma immunoreactive methionine enkephalin levels was not associated with an increase in whole brain or cerebrospinal fluid immunoreactive methionine enkephalin levels.
Positive_regulation (elevation) of methionine enkephalin in plasma associated with enkephalin
3) Confidence 0.40 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1436641 Disease Relevance 0.25 Pain Relevance 0.70
However, this marked elevation in plasma immunoreactive methionine enkephalin levels was not associated with an increase in whole brain or cerebrospinal fluid immunoreactive methionine enkephalin levels.
Positive_regulation (increase) of methionine enkephalin in plasma associated with enkephalin
4) Confidence 0.40 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1436641 Disease Relevance 0.24 Pain Relevance 0.70
These data suggest that increased plasma-to-brain transfer of methionine enkephalin does not occur in this model of acute toxic hepatitis.
Positive_regulation (increased) of methionine enkephalin in plasma associated with drug-induced liver injury and enkephalin
5) Confidence 0.40 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1436641 Disease Relevance 0.33 Pain Relevance 0.68
In order to determine whether acute toxic hepatitis in the rat is associated with an accumulation of methionine enkephalin in plasma and increased blood-to-brain transfer of methionine enkephalin, immunoreactive methionine enkephalin levels were determined by radioimmunoassay in plasma, cerebrospinal fluid and whole brain samples from rats with thioacetamide induced acute toxic hepatitis.
Spec (whether) Positive_regulation (accumulation) of methionine enkephalin in plasma associated with drug-induced liver injury and enkephalin
6) Confidence 0.40 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1436641 Disease Relevance 0.26 Pain Relevance 0.50
Subsequently, diseased optic nerve MTR appeared to rise; after 1 year the diseased optic nerve mean MTR was 45.1 pu (mean lesion ratio 0.93), although the difference was not significant compared with the nadir value.
Spec (appeared) Positive_regulation (rise) of MTR in optic nerve
7) Confidence 0.40 Published 2004 Journal Brain Section Abstract Doc Link 14736754 Disease Relevance 0.35 Pain Relevance 0.25
In the U-50,488H-abstinent rats, methionine-enkephalin concentration was elevated in the heart.
Positive_regulation (elevated) of methionine-enkephalin in heart associated with enkephalin
8) Confidence 0.37 Published 1994 Journal Pharmacology Section Abstract Doc Link 8177908 Disease Relevance 0 Pain Relevance 1.05
D* and its volume fraction decreased at values of w>or=0.3 s, and the normalized apparent diffusion coefficient (ADC) increased with MTR, suggesting that D* is closely correlated with CBVa.
Positive_regulation (increased) of MTR
9) Confidence 0.22 Published 2006 Journal Magn Reson Med Section Abstract Doc Link 16596632 Disease Relevance 0 Pain Relevance 0.14
This phenomenon may be attributed to the synergistic effects of nitrous oxide, which inactivates the cobalamin coenzyme of methionine synthase, and MTX, which inhibits dihydrofolate reductase, on folate metabolism.
Positive_regulation (inactivates) of methionine synthase associated with methotrexate
10) Confidence 0.21 Published 1989 Journal Cancer Res. Section Abstract Doc Link 2804978 Disease Relevance 0.84 Pain Relevance 0.44
In order to determine whether acute toxic hepatitis in the rat is associated with an accumulation of methionine enkephalin in plasma and increased blood-to-brain transfer of methionine enkephalin, immunoreactive methionine enkephalin levels were determined by radioimmunoassay in plasma, cerebrospinal fluid and whole brain samples from rats with thioacetamide induced acute toxic hepatitis.
Spec (whether) Positive_regulation (accumulation) of methionine enkephalin in cerebrospinal fluid associated with drug-induced liver injury and enkephalin
11) Confidence 0.14 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1436641 Disease Relevance 0.26 Pain Relevance 0.50
In vitro study with rat liver methionine synthase has demonstrated that inactivation of methionine synthase was induced by acetaldehyde and ethanol did not inhibit methionine synthase directly (12) (Kenyon et al., 1998).
Positive_regulation (induced) of methionine synthase in liver
12) Confidence 0.12 Published 2008 Journal Nutrition Research and Practice Section Body Doc Link PMC2788200 Disease Relevance 0.09 Pain Relevance 0.04
It has been extensively documented that in vivo inhibition of methionine synthase induced by ethanol plays a critical role in hepatotoxicity and the administration of ethanol depletes hepatic S-adenosylmethionine which protects the liver from ethanol-induced fatty infiltration (Barak et al., 2001; Barak et al., 2003).
Positive_regulation (induced) of methionine synthase in liver associated with hepatotoxicity
13) Confidence 0.12 Published 2008 Journal Nutrition Research and Practice Section Body Doc Link PMC2788200 Disease Relevance 0.10 Pain Relevance 0.05
During abrupt and naloxone-precipitated abstinence, the levels of methionine-enkephalin in the thymus gland are significantly elevated possibly due to an inhibition of their release.
Spec (possibly) Positive_regulation (elevated) of methionine-enkephalin in gland associated with narcan and enkephalin
14) Confidence 0.10 Published 1989 Journal Life Sci. Section Abstract Doc Link 2533311 Disease Relevance 0 Pain Relevance 1.29
Plasma 5-methyl-tetrahydrofolate concentrations increased uniformly by 20% after nitrous oxide anesthesia, indicating the inactivation of methionine synthase and subsequent folate trapping.
Positive_regulation (inactivation) of methionine synthase in Plasma
15) Confidence 0.04 Published 2008 Journal Anesthesiology Section Body Doc Link 18580170 Disease Relevance 0 Pain Relevance 0

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