INT98020

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Context Info
Confidence 0.53
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.21
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PCK1) lyase activity (PCK1) carbohydrate metabolic process (PCK1)
lipid metabolic process (PCK1) cytoplasm (PCK1) cytosol (PCK1)
Anatomy Link Frequency
liver 1
PCK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tramadol 11 99.20 Very High Very High Very High
Opioid 3 93.20 High High
Paracetamol 2 88.04 High High
narcan 4 86.28 High High
cytokine 3 84.24 Quite High
tolerance 5 75.68 Quite High
Immobilon 1 15.20 Low Low
agonist 24 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 39 98.84 Very High Very High Very High
Hepatocellular Cancer 3 93.16 High High
Obesity 140 61.56 Quite High
Chronic Disease 2 50.68 Quite High
Cancer 12 50.00 Quite Low
Metabolic Syndrome 10 48.16 Quite Low
Dyslipidemia /

Combined Dyslipidemia

1 47.24 Quite Low
Hypertension 1 46.68 Quite Low
Cardiovascular Disease 2 45.36 Quite Low
Injury 2 12.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This combination of tracers allows three separate elements of hepatic glucose production (GP) to be probed simultaneously in a single study: 1) endogenous GP, 2) the contribution of glycogen, phosphoenolpyruvate (PEP), and glycerol to GP, and 3) flux through PEP carboxykinase, pyruvate recycling, and the TCA cycle.
Gene_expression (contribution) of PEP carboxykinase
1) Confidence 0.53 Published 2001 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 11551863 Disease Relevance 0 Pain Relevance 0.14
For human cell and tissue studies, identifiers were ADFP (Hs00605340_m1), adiponectin/AdipoQ (Hs00605917_m1), Cpt1b (Hs00992664_m1), PEPCK1/Pck1 (Hs00159918_m1), leptin (Hs00174877_m1), ACOX1 (Hs00244515_m1), and LPL (Hs00173425_m1).


Gene_expression (/) of PEPCK1
2) Confidence 0.24 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.06 Pain Relevance 0
Moreover, similar repeated treatments with tramadol reversed the elevated mRNA and protein levels of phosphoenolpyruvate carboxykinase in the liver of STZ-induced diabetic rats.
Gene_expression (levels) of carboxykinase in liver associated with tramadol and diabetes mellitus
3) Confidence 0.07 Published 2001 Journal Diabetes Section Abstract Doc Link 11723065 Disease Relevance 0.53 Pain Relevance 1.15
The investigators showed that EGCG mimics insulin, increases tyrosine phosphorylation of the insulin receptor and the insulin receptor substrate, and reduces gene expression of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase.
Gene_expression (expression) of carboxykinase
4) Confidence 0.01 Published 2010 Journal Chin Med Section Body Doc Link PMC2855614 Disease Relevance 0.61 Pain Relevance 0.08

General Comments

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