INT98021

Context Info Confidence 0.31 First Reported 2001 Last Reported 2007 Negated 1 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.07 Pain Relevance 0.16

small molecule metabolic process (PCK1) lyase activity (PCK1) carbohydrate metabolic process (PCK1) lipid metabolic process (PCK1) cytoplasm (PCK1) cytosol (PCK1)

Anatomy Link Frequency liver 1 PCK1 (Homo sapiens)

Pain Link Frequency Relevance Heat Paracetamol 2 99.36 cINOD 1 47.68

Disease Link Frequency Relevance Heat Body Weight 1 69.60 INFLAMMATION 1 47.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, (13)C NMR isotopomer analysis of phenylacetylglutamine and acetaminophen glucuronide reported different values for PEP carboxykinase flux (68.8 +/- 9.8 vs. 37.5 +/- 7.9 micromol.kg(-1).min(-1)), PEP recycling flux (59.1 +/- 9.8 vs. 27.8 +/- 6.8 micromol.kg(-1).min(-1)), and TCA cycle flux (10.9 +/- 1.4 vs. 5.4 +/- 1.4 micromol.kg(-1).min(-1)).

Regulation (values) of PEP carboxykinase associated with paracetamol

1) Confidence 0.31 Published 2001 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 11551863 Disease Relevance 0 Pain Relevance 0.16

Salicylate impact on liver metabolic capacity involved depressed liver glycogen content, whereas no significant changes in liver hexokinase, glucokinase, lactate dehydrogenase, pyruvate kinase, phosphoenolpyruvate carboxykinase, aspartate aminotransferase and alanine aminotransferase activities were observed.

Neg (no) Regulation (changes) of carboxykinase in liver

2) Confidence 0.00 Published 2007 Journal Aquat. Toxicol. Section Abstract Doc Link 17889947 Disease Relevance 0.07 Pain Relevance 0

General Comments

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