INT98021

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Context Info
Confidence 0.31
First Reported 2001
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PCK1) lyase activity (PCK1) carbohydrate metabolic process (PCK1)
lipid metabolic process (PCK1) cytoplasm (PCK1) cytosol (PCK1)
Anatomy Link Frequency
liver 1
PCK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 2 99.36 Very High Very High Very High
cINOD 1 47.68 Quite Low
Disease Link Frequency Relevance Heat
Body Weight 1 69.60 Quite High
INFLAMMATION 1 47.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, (13)C NMR isotopomer analysis of phenylacetylglutamine and acetaminophen glucuronide reported different values for PEP carboxykinase flux (68.8 +/- 9.8 vs. 37.5 +/- 7.9 micromol.kg(-1).min(-1)), PEP recycling flux (59.1 +/- 9.8 vs. 27.8 +/- 6.8 micromol.kg(-1).min(-1)), and TCA cycle flux (10.9 +/- 1.4 vs. 5.4 +/- 1.4 micromol.kg(-1).min(-1)).
Regulation (values) of PEP carboxykinase associated with paracetamol
1) Confidence 0.31 Published 2001 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 11551863 Disease Relevance 0 Pain Relevance 0.16
Salicylate impact on liver metabolic capacity involved depressed liver glycogen content, whereas no significant changes in liver hexokinase, glucokinase, lactate dehydrogenase, pyruvate kinase, phosphoenolpyruvate carboxykinase, aspartate aminotransferase and alanine aminotransferase activities were observed.
Neg (no) Regulation (changes) of carboxykinase in liver
2) Confidence 0.00 Published 2007 Journal Aquat. Toxicol. Section Abstract Doc Link 17889947 Disease Relevance 0.07 Pain Relevance 0

General Comments

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