INT9803

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Context Info
Confidence 0.60
First Reported 1989
Last Reported 1992
Negated 0
Speculated 4
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 1.45
Pain Relevance 4.36

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methyltransferase activity (Mtr) intracellular (Mtr) cytoplasm (Mtr)
Anatomy Link Frequency
plasma 9
gland 2
cerebrospinal fluid 1
Mtr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 46 100.00 Very High Very High Very High
narcan 5 99.40 Very High Very High Very High
Opioid 1 95.12 Very High Very High Very High
Morphine 9 94.20 High High
withdrawal 1 49.56 Quite Low
Disease Link Frequency Relevance Heat
Drug-induced Liver Injury 20 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that increased plasma-to-brain transfer of methionine enkephalin does not occur in this model of acute toxic hepatitis.
Positive_regulation (transfer) of Gene_expression (transfer) of methionine enkephalin in plasma associated with drug-induced liver injury and enkephalin
1) Confidence 0.60 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1436641 Disease Relevance 0.33 Pain Relevance 0.68
These data suggest that increased plasma-to-brain transfer of methionine enkephalin does not occur in this model of acute toxic hepatitis.
Positive_regulation (increased) of Gene_expression (transfer) of methionine enkephalin in plasma associated with drug-induced liver injury and enkephalin
2) Confidence 0.60 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1436641 Disease Relevance 0.33 Pain Relevance 0.68
In order to determine whether acute toxic hepatitis in the rat is associated with an accumulation of methionine enkephalin in plasma and increased blood-to-brain transfer of methionine enkephalin, immunoreactive methionine enkephalin levels were determined by radioimmunoassay in plasma, cerebrospinal fluid and whole brain samples from rats with thioacetamide induced acute toxic hepatitis.
Spec (whether) Positive_regulation (increased) of Gene_expression (transfer) of methionine enkephalin in plasma associated with drug-induced liver injury and enkephalin
3) Confidence 0.40 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1436641 Disease Relevance 0.27 Pain Relevance 0.57
In order to determine whether acute toxic hepatitis in the rat is associated with an accumulation of methionine enkephalin in plasma and increased blood-to-brain transfer of methionine enkephalin, immunoreactive methionine enkephalin levels were determined by radioimmunoassay in plasma, cerebrospinal fluid and whole brain samples from rats with thioacetamide induced acute toxic hepatitis.
Spec (whether) Positive_regulation (transfer) of Gene_expression (transfer) of methionine enkephalin in plasma associated with drug-induced liver injury and enkephalin
4) Confidence 0.40 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1436641 Disease Relevance 0.27 Pain Relevance 0.57
In order to determine whether acute toxic hepatitis in the rat is associated with an accumulation of methionine enkephalin in plasma and increased blood-to-brain transfer of methionine enkephalin, immunoreactive methionine enkephalin levels were determined by radioimmunoassay in plasma, cerebrospinal fluid and whole brain samples from rats with thioacetamide induced acute toxic hepatitis.
Spec (whether) Positive_regulation (increased) of in cerebrospinal fluid Gene_expression (transfer) of methionine enkephalin in plasma associated with drug-induced liver injury and enkephalin
5) Confidence 0.14 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1436641 Disease Relevance 0.27 Pain Relevance 0.57
During abrupt and naloxone-precipitated abstinence, the levels of methionine-enkephalin in the thymus gland are significantly elevated possibly due to an inhibition of their release.
Spec (possibly) Positive_regulation (elevated) of Gene_expression (levels) of methionine-enkephalin in gland associated with narcan and enkephalin
6) Confidence 0.07 Published 1989 Journal Life Sci. Section Abstract Doc Link 2533311 Disease Relevance 0 Pain Relevance 1.29

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