INT98068

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 14.42
Pain Relevance 3.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN2A)
Anatomy Link Frequency
cerebellum 2
blood 1
plasma 1
neurons 1
Paw 1
SCN2A (Homo sapiens)
Pain Link Frequency Relevance Heat
nav1.8 9 100.00 Very High Very High Very High
Nav1.6 7 100.00 Very High Very High Very High
Nav1.7 7 100.00 Very High Very High Very High
nav1.3 7 100.00 Very High Very High Very High
Nav1.2 6 100.00 Very High Very High Very High
Nav1.9 4 100.00 Very High Very High Very High
Nav1.1 8 99.78 Very High Very High Very High
Hyperalgesia 3 97.84 Very High Very High Very High
Chronic pancreatitis 6 96.60 Very High Very High Very High
withdrawal 2 96.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sickle Cell Anemia 68 99.80 Very High Very High Very High
Diabetes Mellitus 38 99.28 Very High Very High Very High
Thalassemia 376 99.06 Very High Very High Very High
Disease 56 97.96 Very High Very High Very High
Hyperalgesia 3 97.84 Very High Very High Very High
Pancreatitis 6 96.60 Very High Very High Very High
Stress 24 96.56 Very High Very High Very High
Malaria 129 94.72 High High
Fever 17 93.60 High High
Hypoglycemia 3 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paw withdrawal threshold and withdrawal latency (to mechanical and thermal stimuli, respectively) and grip force were lower in homozygous and hemizygous Berkley mice (BERK and hBERK1, respectively) compared with control mice expressing human hemoglobin A (HbA-BERK), indicating deep/musculoskeletal and cutaneous hyperalgesia.
Gene_expression (expressing) of HbA in Paw associated with hyperalgesia and withdrawal
1) Confidence 0.75 Published 2010 Journal Blood Section Abstract Doc Link 20304807 Disease Relevance 0.66 Pain Relevance 0.92
The results demonstrate (a) the high quality of whole-cell recordings obtainable from cell lines expressing human Nav1.2 or hERG ion channels, (b) the advantages of the methodology for increasing throughput, and (c) examples of how these assays support ion channel drug discovery.
Gene_expression (expressing) of Nav1.2 associated with nav1.2
2) Confidence 0.75 Published 2009 Journal Methods Mol. Biol. Section Abstract Doc Link 19551364 Disease Relevance 0 Pain Relevance 0.10
subunits SCN1A (Nav1.1, 225 bp), SCN2A (Nav1.2, 297 bp), SCN3A (Nav1.3, 367 bp), SCN4A (Nav1.4, 317 bp), SCN5A (Nav1.5, 294 bp), SCN8A (Nav1.6, 207 bp), SCN9A (Nav1.7, 289 bp), SCN10A (Nav1.8, 347 bp), SCN11A (Nav1.9, 272 bp) and the related isoform SCN7A (Nax, 327 bp) were all expressed in human sperm cDNA (Fig 1).
Gene_expression (expressed) of SCN2A in sperm associated with nav1.3, nav1.1, nav1.2, nav1.8, nav1.7, nav1.6 and nav1.9
3) Confidence 0.74 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.98
The results of the present study indicate that miglitol reduces fasting and postprandial plasma glucose levels, Improving glycaemic control, which is reflected in a reduced HbA(1C) level in patients with type 2 diabetes mellitus.
Gene_expression (level) of HbA in plasma associated with diabetes mellitus
4) Confidence 0.65 Published 2007 Journal J Indian Med Assoc Section Abstract Doc Link 18232183 Disease Relevance 1.27 Pain Relevance 0.14
RESULTS: The patients had similar baseline characteristics for pain intensity, HbA(1c), and duration of DSP.
Gene_expression (duration) of HbA
5) Confidence 0.65 Published 2004 Journal Diabetes Care Section Body Doc Link 15047649 Disease Relevance 0.30 Pain Relevance 0
The apo A-IV concentration was positively correlated with hemoglobin A(1c) (HbA(1c)) percentage in each group of diabetic patients (CP-DM, r =.35; P =.046; type 1 DM, r =.53; P =.010), in both groups of diabetic patients (r =.472; P <.0001) and negatively correlated with ceruloplasmin concentration in each group of diabetic patients (CP-DM, r = -.48; P =.0052; type 1 DM, r = -.66; P =.003), in both groups of diabetic patients (r = -.561; P <.0001), and in the whole population (r = -.463; P <.0001).
Gene_expression (percentage) of HbA associated with diabetes mellitus
6) Confidence 0.65 Published 2001 Journal Metab. Clin. Exp. Section Abstract Doc Link 11555832 Disease Relevance 2.66 Pain Relevance 0.62
Reverse transcriptase-polymerase chain reaction (RT-PCR) and real-time PCR analysis of MPM cells transcripts showed significant expression of the mRNAs encoding for Na(V)1.2, and Na(V)1.6, and Na(V)1.7 (and less so for Na(V)1.3, Na(V)1.4, and Na(V)1.5) main voltage-gated sodium channel (VGSC) alpha-subunit(s).
Gene_expression (expression) of Na(V)1.2 associated with sodium channel
7) Confidence 0.58 Published 2006 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 16458569 Disease Relevance 0.30 Pain Relevance 0.43
The developmentally increasing expression of Na(V)1.2 in cerebellum may be responsible for the later onset of episodic ataxia.


Gene_expression (expression) of Na(V)1.2 in cerebellum
8) Confidence 0.58 Published 2010 Journal Neurology Section Body Doc Link 20956790 Disease Relevance 0.17 Pain Relevance 0
We studied the developmental expression of Na(V)1.2 in cerebellum by immunohistochemical analysis.
Gene_expression (expression) of Na(V)1.2 in cerebellum
9) Confidence 0.58 Published 2010 Journal Neurology Section Body Doc Link 20956790 Disease Relevance 0.26 Pain Relevance 0
Immunohistochemical studies suggest a developmentally increasing expression of Na(V)1.2 in granule cell axons projecting to Purkinje neurons.
Gene_expression (expression) of Na(V)1.2 in neurons
10) Confidence 0.58 Published 2010 Journal Neurology Section Body Doc Link 20956790 Disease Relevance 0.20 Pain Relevance 0
We found that four of the five investigated genes, HBA, HBB, HBE and HEBP1, showed decreased expression levels in foxes selected for tameness compared to non-selected farm foxes.
Gene_expression (expression) of HBA
11) Confidence 0.37 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0 Pain Relevance 0
For three of the genes, HBA, HBE and HEBP1, an additive genetic component did indeed appear to explain the observed expression variation.
Gene_expression (expression) of HBA
12) Confidence 0.32 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0 Pain Relevance 0
C) mutation had significant levels of HbA, indicating that this mutation is a relatively milder ?
Gene_expression (levels) of HbA
13) Confidence 0.28 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009427 Disease Relevance 1.31 Pain Relevance 0
C) mutation had low HbA levels (3–5%) similar to that observed with the IVS II-745 mutation and it had been concluded that this level of HbA does not influence the clinical expression of the disease compared to sickle cell disease in the community.[14] In the present study, codon 15 (G?
Gene_expression (levels) of HbA associated with sickle cell anemia and disease
14) Confidence 0.28 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009427 Disease Relevance 1.36 Pain Relevance 0
C) mutation had low HbA levels (3–5%) similar to that observed with the IVS II-745 mutation and it had been concluded that this level of HbA does not influence the clinical expression of the disease compared to sickle cell disease in the community.[14] In the present study, codon 15 (G?
Gene_expression (level) of HbA associated with sickle cell anemia and disease
15) Confidence 0.28 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009427 Disease Relevance 1.38 Pain Relevance 0
Thus to evaluate the potential effect of blood perfusion on HBE and HEBP1 expression levels, we assumed that the average HBA and HBB levels (HB) could represent the maximum effect of blood perfusion caused by e.g. a systemic stress response.
Gene_expression (levels) of HBA in blood associated with stress
16) Confidence 0.28 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0.10 Pain Relevance 0
The simulated frequencies of HbA and HbS alleles for Massalit, reached equilibrium (0.52 for HbA and0.48 for HbS) in the fourth generation(Figure 2).
Gene_expression (alleles) of HbA
17) Confidence 0.19 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829010 Disease Relevance 0.57 Pain Relevance 0
A total of 546 individuals (261 from Hausa and 285 from Massalit) were screened for the normal haemoglobin HbA and haemoglobin HbS variants.
Gene_expression (screened) of HbA
18) Confidence 0.19 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829010 Disease Relevance 1.14 Pain Relevance 0.08
The most prevalent polymorphic variants of the HbB gene consist of the normal gene (HbA) in which SNPs in the same amino acid position give rise to either the sickle haemoglobin S, (HbS, Glu to Val at c6 (E6V)) or the common west-African haemoglobin C (HbC, Glu to Lys at c6 (E6K)).
Gene_expression (consist) of HbA
19) Confidence 0.10 Published 2005 Journal Malar J Section Body Doc Link PMC1326224 Disease Relevance 0.54 Pain Relevance 0.04
In beta+ thalassemia homozygotes and beta+/beta0 genetic compounds HbA levels are between 10 and 30% and HbF between 70-90%.
Gene_expression (levels) of HbA associated with thalassemia
20) Confidence 0.03 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2893117 Disease Relevance 1.03 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox