INT98072

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Context Info
Confidence 0.68
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 13
Disease Relevance 5.37
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LAT) intracellular (LAT)
Anatomy Link Frequency
monocytes 4
macrophages 3
fibroblasts 1
ganglia 1
LAT (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 111 88.48 High High
Multiple sclerosis 14 83.24 Quite High
Central nervous system 42 80.92 Quite High
Neuritis 2 72.88 Quite High
Spinal cord 8 62.08 Quite High
imagery 54 5.00 Very Low Very Low Very Low
Pain 32 5.00 Very Low Very Low Very Low
Inflammation 24 5.00 Very Low Very Low Very Low
positron emission tomography 24 5.00 Very Low Very Low Very Low
Nerve growth factor 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 742 100.00 Very High Very High Very High
Lysosome Storage Disease 16 99.32 Very High Very High Very High
Pulmonary Alveolar Proteinosis 315 96.88 Very High Very High Very High
Syndrome 13 96.20 Very High Very High Very High
Herpes Simplex Virus 12 95.76 Very High Very High Very High
Spontaneous Remission 9 92.84 High High
Cranial Neuropathy 2 91.68 High High
Injury 6 83.88 Quite High
Demyelinating Disease 20 83.24 Quite High
Granuloma 9 82.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LAT was found on both sides in allTG (100%), on both sides of five subjects (70%) in the GG, and in none of the VG.
Neg (none) Gene_expression (found) of LAT
1) Confidence 0.68 Published 2001 Journal Brain Pathol. Section Abstract Doc Link 11556685 Disease Relevance 0.63 Pain Relevance 0.07
Prevalence of HSV-1 LAT in human trigeminal, geniculate, and vestibular ganglia and its implication for cranial nerve syndromes.
Gene_expression (Prevalence) of LAT in ganglia associated with cold sores and syndrome
2) Confidence 0.68 Published 2001 Journal Brain Pathol. Section Title Doc Link 11556685 Disease Relevance 0.68 Pain Relevance 0.06
Alternatively, GM-CSF-dependent increase of SLC7A7 mRNA may lead to an enhanced synthesis of y+LAT1 protein that ameliorates macrophage function.
Gene_expression (synthesis) of LAT1 in macrophage
3) Confidence 0.42 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.40 Pain Relevance 0
Nevertheless, the link between GM-CSF, impaired y+LAT1 expression and surfactant accumulation in LPI remains to be elucidated, and our report is not conclusive, taking into consideration the single case and the possibility, although rare, of a spontaneous remission of PAP.
Gene_expression (expression) of LAT1 associated with pulmonary alveolar proteinosis and spontaneous remission
4) Confidence 0.42 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.58 Pain Relevance 0
To assess if a different pattern of expression of SLC7A7/y+LAT1 and SLC7A6/y+LAT2 in LPI monocytes, macrophages and fibroblasts may justify the different transport phenotype of these cells, the expression of both genes was evaluated as number of mRNA molecules.
Gene_expression (expression) of LAT1 in monocytes
5) Confidence 0.32 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
We have found that: 1) system y+L activity is markedly lowered in monocytes and alveolar macrophages from the LPI patient, because of the prevailing expression of SLC7A7/y+LAT1 in these cells; 2) on the contrary, fibroblasts isolated from the same patient do not display the transport defect due to compensation by the SLC7A6/y+LAT2 isoform; 3) in both normal and LPI monocytes, GM-CSF induces the expression of SLC7A7, suggesting that the gene is a target of the cytokine; 4) GM-CSF-induced differentiation of LPI monocytes is comparable to that of normal cells, demonstrating that GM-CSF signalling is unaltered; 5) general and respiratory conditions of the patient, along with PAP-associated parameters, markedly improved after GM-CSF therapy through aerosolization.


Gene_expression (expression) of LAT1 in monocytes associated with pulmonary alveolar proteinosis and cytokine
6) Confidence 0.32 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2999609 Disease Relevance 0.34 Pain Relevance 0.04
Hence, whereas a normal expression of SLC7A6/y+LAT2 can compensate for the mutation of SLC7A7/y+LAT1 in LPI fibroblasts, the prevailing expression of y+LAT1 in monocytes and AM explains the typical LPI tissue-specific transport defect in these cells.
Gene_expression (expression) of LAT1 in monocytes
7) Confidence 0.32 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0.04
The present study investigates for the first time the expression and function of y+LAT1 in monocytes and macrophages isolated from a patient affected by LPI-associated PAP.
Gene_expression (expression) of LAT1 in monocytes associated with pulmonary alveolar proteinosis
8) Confidence 0.32 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2999609 Disease Relevance 0.37 Pain Relevance 0
The investigators have demonstrated the capacity of HSV1716 virus expressing GUSB driven by the latency-associated transcript promoter (HSV-1716-LAT-GUSB virus) to correct the lysosomal storage in the adult MPS VII mouse model following intracranial injection.
Gene_expression (expressing) of LAT associated with cold sores and lysosome storage disease
9) Confidence 0.13 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.01 Pain Relevance 0.11
The investigators have demonstrated the capacity of HSV1716 virus expressing GUSB driven by the latency-associated transcript promoter (HSV-1716-LAT-GUSB virus) to correct the lysosomal storage in the adult MPS VII mouse model following intracranial injection.
Gene_expression (virus) of LAT associated with cold sores and lysosome storage disease
10) Confidence 0.13 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.99 Pain Relevance 0.11
The present study investigates for the first time the expression and function of y+LAT1 in monocytes and macrophages isolated from a patient affected by LPI-associated PAP.
Gene_expression (expression) of LAT1 in macrophages associated with pulmonary alveolar proteinosis
11) Confidence 0.11 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2999609 Disease Relevance 0.37 Pain Relevance 0
To assess if a different pattern of expression of SLC7A7/y+LAT1 and SLC7A6/y+LAT2 in LPI monocytes, macrophages and fibroblasts may justify the different transport phenotype of these cells, the expression of both genes was evaluated as number of mRNA molecules.
Gene_expression (expression) of LAT1 in fibroblasts
12) Confidence 0.11 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
To assess if a different pattern of expression of SLC7A7/y+LAT1 and SLC7A6/y+LAT2 in LPI monocytes, macrophages and fibroblasts may justify the different transport phenotype of these cells, the expression of both genes was evaluated as number of mRNA molecules.
Gene_expression (expression) of LAT1 in macrophages
13) Confidence 0.11 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0

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