INT98096

Context Info Confidence 0.42 First Reported 2001 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 14 Total Number 14 Disease Relevance 12.23 Pain Relevance 1.61

signal transduction (CHKA) lipid metabolic process (CHKA) cytoplasm (CHKA) signal transducer activity (CHKA)

Anatomy Link Frequency blood 1 plasma 1 thyroid 1 CHKA (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammatory marker 3 98.32 Pain 14 97.68 fibrosis 6 90.16 Angina 14 86.68 Inflammation 55 83.64 imagery 41 79.76 cINOD 3 78.80 Inflammatory response 7 78.32 drug abuse 2 73.84 alcohol 3 70.28

Disease Link Frequency Relevance Heat Disorders Of Creatine Metabolism 1 99.88 Myocardial Infarction 142 99.86 Death 79 99.30 Heart Rate Under Development 101 99.10 INFLAMMATION 63 98.00 Pain 12 97.68 Cancer 82 97.12 Hepatocellular Cancer 66 97.04 Carcinoma 18 96.96 Hemangioma 6 95.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In keeping with prior studies, we were able to demonstrate a graded risk of adverse cardiovascular outcomes (defined as new CHF and death) with a statistically significant increase of events in patients in higher quintiles of peak and AUC measurements for both CK and CK-MB.

Positive_regulation (increase) of CK associated with heart rate under development and death

1) Confidence 0.42 Published 2005 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC1236947 Disease Relevance 0.81 Pain Relevance 0.09

SPECT infarct size also correlated with the AUC measurements for both CK (r = 0.63, P < 0.0001) and CK-MB (r = 0.58, P < 0.0001) (Table 2).

Positive_regulation (measurements) of CK

2) Confidence 0.42 Published 2005 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC1236947 Disease Relevance 0.23 Pain Relevance 0.04

In keeping with prior studies, we were able to demonstrate a graded risk of adverse cardiovascular outcomes (defined as new CHF and death) with a statistically significant increase of events in patients in higher quintiles of peak and AUC measurements for both CK and CK-MB.

Positive_regulation (increase) of CK associated with heart rate under development and death

3) Confidence 0.42 Published 2005 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC1236947 Disease Relevance 0.81 Pain Relevance 0.09

SPECT infarct size also correlated with the AUC measurements for both CK (r = 0.63, P < 0.0001) and CK-MB (r = 0.58, P < 0.0001) (Table 2).

Positive_regulation (measurements) of CK

4) Confidence 0.42 Published 2005 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC1236947 Disease Relevance 0.23 Pain Relevance 0.04

In addition, LDH and CK activities were elevated to a greater extent in the vitamin C and NAC group.

Positive_regulation (elevated) of CK

5) Confidence 0.41 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11557312 Disease Relevance 1.26 Pain Relevance 0.26

Patients from both trials were excluded from analyses if they had a history of MI or no elevation of CK or CK-MB due to confounding.

Neg (no) Positive_regulation (elevation) of CK associated with myocardial infarction

6) Confidence 0.39 Published 2005 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC1236947 Disease Relevance 0.33 Pain Relevance 0

Patients from both trials were excluded from analyses if they had a history of MI or no elevation of CK or CK-MB due to confounding.

Neg (no) Positive_regulation (elevation) of CK associated with myocardial infarction

7) Confidence 0.39 Published 2005 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC1236947 Disease Relevance 0.33 Pain Relevance 0

The concentrations of lactate dehydrogenase (LDH), creatine kinase (CK), and myoglobin were significantly elevated 2, 3, and 4 d postinjury and returned to baseline levels by day 7.

Positive_regulation (elevated) of CK

8) Confidence 0.30 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11557312 Disease Relevance 1.31 Pain Relevance 0.27

In scattered areas, cells were immunochemically positive for cytokeratin (CK) 7 and negative for CK 20.

Positive_regulation (negative) of CK

9) Confidence 0.16 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2246133 Disease Relevance 1.78 Pain Relevance 0.04

Elevated ALT, AST, creatine kinase (CK), creatine phosphokinase isoenzymes (CPK), lactic dehydrogenase (LDH), and plasma glucose concentration, and decreased albumin levels were observed in more than half of cases at admission, and developed in nearly all cases during hospitalization.

Positive_regulation (Elevated) of CK in plasma associated with disorders of creatine metabolism

10) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515635 Disease Relevance 0.51 Pain Relevance 0.03

In our case, the thyroid sample was negative for TTF-1, CK 7, and CK 20, but positive for alpha-fetoprotein, which is relatively specific for HCC, although of low sensitivity [14].

Positive_regulation (negative) of CK in thyroid associated with hepatocellular cancer

11) Confidence 0.14 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2246133 Disease Relevance 1.01 Pain Relevance 0.07

In scattered areas, cells were immunochemically positive for cytokeratin (CK) 7 and negative for CK 20.

Positive_regulation (negative) of CK

12) Confidence 0.14 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2246133 Disease Relevance 1.79 Pain Relevance 0.04

All patients had a routine measurement of CK and troponin I at enrolment, none of them reaching the positive threshold as per local hospital reference ( >0.032 ng/ml).

Positive_regulation (measurement) of CK

13) Confidence 0.06 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2820266 Disease Relevance 0.77 Pain Relevance 0.24

The LDH, CK-CPK, myoglobinemia, aldolase, GOT and GPT blood tests were very elevated (CPK 9,351 U/l).

Positive_regulation (elevated) of CK-CPK in blood

14) Confidence 0.04 Published 2008 Journal J Orthop Traumatol Section Body Doc Link PMC2656963 Disease Relevance 1.07 Pain Relevance 0.40

General Comments

This test has worked.