INT98099

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Context Info
Confidence 0.02
First Reported 2001
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.72
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (RFFL) ligase activity (RFFL) cytoplasm (RFFL)
Anatomy Link Frequency
motoneurons 2
neuronal 1
RFFL (Homo sapiens)
Pain Link Frequency Relevance Heat
Sciatica 4 100.00 Very High Very High Very High
Paracetamol 9 99.02 Very High Very High Very High
cINOD 7 84.88 Quite High
Analgesic 1 64.64 Quite High
local anesthetic 2 50.00 Quite Low
lidocaine 2 50.00 Quite Low
methotrexate 5 37.60 Quite Low
aspirin 1 25.00 Low Low
rheumatoid arthritis 19 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 6 99.68 Very High Very High Very High
Apoptosis 69 99.38 Very High Very High Very High
Necrosis 7 89.48 High High
Injury 9 82.24 Quite High
Hepatocellular Cancer 2 78.36 Quite High
INFLAMMATION 11 69.68 Quite High
Stress 2 62.88 Quite High
Drug Induced Neurotoxicity 1 49.72 Quite Low
Rheumatoid Arthritis 19 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AAP-induced apoptosis and cell death was blocked by inhibitors of caspases but not by inhibitors of calpains, cathepsins, and serine proteases.
Negative_regulation (inhibitors) of caspases associated with paracetamol, apoptosis and death
1) Confidence 0.02 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15665138 Disease Relevance 1.31 Pain Relevance 0.73
Triptolide-induced DNA fragmentation in RSF was suppressed by Z-DEVD-FMK, Z-IETD-FMK, and Z-LEHD-FMK, inhibitors of caspases-3, -8 and -9, respectively, in concentration dependent manner (Figure 6).


Negative_regulation (inhibitors) of caspases
2) Confidence 0.00 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC373449 Disease Relevance 0.40 Pain Relevance 0
Pretreatment of cells with inhibitors of caspases or protein synthesis suppressed cell death caused by long-term indomethacin treatment, suggesting that apoptosis was induced when the inhibitors were not present.
Negative_regulation (inhibitors) of caspases associated with apoptosis and death
3) Confidence 0.00 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11557530 Disease Relevance 0.68 Pain Relevance 0.38
Treatment with z-VAD-fmk, a specific inhibitor of caspases, prevented caspase activation and delayed but did not prevent neuronal death, but did not inhibit the other indicators of apoptosis.
Negative_regulation (inhibitor) of caspases in neuronal
4) Confidence 0.00 Published 2004 Journal Anesthesiology Section Body Doc Link 15505455 Disease Relevance 0 Pain Relevance 0
Collectively, these data provide evidence that injured neonatal motoneurons can survive and reinnervate peripheral muscle targets following inhibition of caspases.
Negative_regulation (inhibition) of caspases in motoneurons
5) Confidence 0.00 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 12781992 Disease Relevance 0.21 Pain Relevance 0
Inhibition of caspases promotes long-term survival and reinnervation by axotomized spinal motoneurons of denervated muscle in newborn rats.
Negative_regulation (Inhibition) of caspases in motoneurons associated with sciatica
6) Confidence 0.00 Published 2003 Journal Exp. Neurol. Section Title Doc Link 12781992 Disease Relevance 0.13 Pain Relevance 0.20

General Comments

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