INT98109

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Context Info
Confidence 0.52
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 6.87
Pain Relevance 14.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a3)
Anatomy Link Frequency
spinal cord 2
dorsal root 1
spinal 1
nerve 1
brain 1
Slc1a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 742 100.00 Very High Very High Very High
Spinal cord 141 100.00 Very High Very High Very High
Antinociceptive 21 99.78 Very High Very High Very High
Morphine 28 99.42 Very High Very High Very High
Endep 7 99.04 Very High Very High Very High
excitatory amino acid 10 98.92 Very High Very High Very High
qutenza 17 98.88 Very High Very High Very High
Analgesic 3 98.78 Very High Very High Very High
Pain 143 98.76 Very High Very High Very High
sodium channel 6 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 31 99.36 Very High Very High Very High
Diabetes Mellitus 70 99.32 Very High Very High Very High
Pain 185 98.76 Very High Very High Very High
Nociception 59 96.68 Very High Very High Very High
Cv Unclassified Under Development 46 96.00 Very High Very High Very High
Hypoxia 8 95.48 Very High Very High Very High
Ganglion Cysts 45 94.04 High High
Hypersensitivity 26 91.56 High High
Anxiety Disorder 4 90.88 High High
Pathologic Processes 5 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amitriptyline preserves morphine's antinociceptive effect by regulating the glutamate transporter GLAST and GLT-1 trafficking and excitatory amino acids concentration in morphine-tolerant rats.
Regulation (regulating) of GLAST associated with glutamate, antinociceptive, endep, excitatory amino acid and morphine
1) Confidence 0.52 Published 2007 Journal Pain Section Title Doc Link 17346885 Disease Relevance 0 Pain Relevance 1.88
However, studies have suggested that a change of glutamate transporter function plays a critical role in the sustained elevation of extracellular glutamate levels during ischemia and hypoxia [9,15].
Regulation (change) of glutamate transporter associated with glutamate, hypoxia and ischemia
2) Confidence 0.44 Published 2007 Journal Mol Pain Section Body Doc Link PMC1864984 Disease Relevance 1.63 Pain Relevance 1.08
The glutamate transporter inhibitor l-trans-pyrrolidine-2,4-dicarboxylic acid either increased or reduced the basal frequency of sIPSCs but did not significantly alter the potentiating effect of capsaicin on sIPSCs.
Neg (not) Regulation (alter) of glutamate transporter associated with glutamate and qutenza
3) Confidence 0.42 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18079355 Disease Relevance 0.28 Pain Relevance 1.13
Thus, glutamate transporter currents elicited in response to dorsal root entry zone stimulation is dependent on the synaptic release of glutamate.
Regulation (dependent) of glutamate transporter in dorsal root associated with glutamate
4) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2713213 Disease Relevance 0 Pain Relevance 0.44
We directly tested this hypothesis by comparing the effects of glutamate transporter inhibition on excitatory post-synaptic currents (EPSCs) in the spinal cord dorsal horn of opiate naïve and opiate tolerant rats.
Regulation (effects) of glutamate transporter in spinal cord dorsal horn associated with glutamate, dorsal horn, opiate and spinal cord
5) Confidence 0.29 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16949209 Disease Relevance 0.16 Pain Relevance 2.00
Several mechanisms potentially contribute to the role of the glutamate transporter inhibitors under pathological pain states (Fig. 4).
Regulation (role) of glutamate transporter associated with pain and glutamate
6) Confidence 0.27 Published 2005 Journal Mol Pain Section Body Doc Link PMC1274343 Disease Relevance 0.76 Pain Relevance 1.23
Thus, more selective drugs that promote spinal glutamate transporter function are needed to demonstrate whether glutamate transporter activators have possible efficacy in the treatment of chronic pain.
Regulation (promote) of glutamate transporter in spinal associated with glutamate and lasting pain
7) Confidence 0.27 Published 2005 Journal Mol Pain Section Body Doc Link PMC1274343 Disease Relevance 0.83 Pain Relevance 1.19
Importantly, the cellular location of GLT-1 and GLAST was also altered in response to nerve injury.
Regulation (altered) of GLAST in nerve associated with nervous system injury
8) Confidence 0.22 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2676254 Disease Relevance 0.27 Pain Relevance 0.30
Role of spinal cord glutamate transporter during normal sensory transmission and pathological pain states

Glutamate is a neurotransmitter critical for spinal excitatory synaptic transmission and for generation and maintenance of spinal states of pain hypersensitivity via activation of glutamate receptors.

Regulation (Role) of glutamate transporter in spinal cord associated with pain, neurotransmitter, glutamate, glutamate receptor, hypersensitivity, stimulus evoked pain and spinal cord
9) Confidence 0.14 Published 2005 Journal Mol Pain Section Title Doc Link PMC1274343 Disease Relevance 0.70 Pain Relevance 1.14
Role of the spinal cord glutamate transporter in normal sensory transmission
Regulation (Role) of glutamate transporter in spinal cord associated with glutamate and spinal cord
10) Confidence 0.14 Published 2005 Journal Mol Pain Section Body Doc Link PMC1274343 Disease Relevance 0.66 Pain Relevance 0.97
The glutamate/aspartate transporter GLAST/EAAT1 plays the major role in glutamate removal and is regulated at different levels: transcription, post-translational modifications and cytoplasmic trafficking.
Regulation (regulated) of GLAST associated with glutamate
11) Confidence 0.13 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18336953 Disease Relevance 0.33 Pain Relevance 0.37
On the other hand, there were no significant changes in GLAST mRNA levels in any brain regions.
Neg (no) Regulation (changes) of GLAST mRNA in brain
12) Confidence 0.06 Published 2001 Journal Yakugaku Zasshi Section Abstract Doc Link 11558151 Disease Relevance 0.15 Pain Relevance 1.45
The aim of this work was to gain insight into a plausible effect of valproate in GLAST function.
Regulation (effect) of GLAST
13) Confidence 0.06 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18336953 Disease Relevance 0.30 Pain Relevance 0.33
Although alterations in glutamate transporter activity during diabetes remain controversial, impairment of GS activity has been previously reported [38-40].
Regulation (alterations) of glutamate transporter associated with glutamate and diabetes mellitus
14) Confidence 0.04 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925907 Disease Relevance 0.81 Pain Relevance 0.24
Regulation of the glutamate transporter EAAC1 by expression and activation of delta-opioid receptor.
Regulation (Regulation) of glutamate transporter associated with glutamate and opioid receptor
15) Confidence 0.02 Published 2006 Journal Eur. J. Neurosci. Section Title Doc Link 16882010 Disease Relevance 0 Pain Relevance 0.67

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