INT98110

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Context Info
Confidence 0.62
First Reported 2001
Last Reported 2010
Negated 2
Speculated 5
Reported most in Abstract
Documents 16
Total Number 21
Disease Relevance 11.76
Pain Relevance 17.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a2)
Anatomy Link Frequency
spinal cord 8
spinal 8
dorsal horn 4
motor neurons 2
sciatic nerve 2
Slc1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 353 100.00 Very High Very High Very High
Spinal cord 230 100.00 Very High Very High Very High
Deafferentation 2 100.00 Very High Very High Very High
Neuropathic pain 142 99.84 Very High Very High Very High
Inflammation 122 99.84 Very High Very High Very High
Hyperalgesia 74 99.32 Very High Very High Very High
intrathecal 30 99.08 Very High Very High Very High
withdrawal 52 98.80 Very High Very High Very High
spinal dorsal horn 43 98.80 Very High Very High Very High
Endep 22 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 246 99.84 Very High Very High Very High
INFLAMMATION 122 99.84 Very High Very High Very High
Nociception 136 99.76 Very High Very High Very High
Hyperalgesia 88 99.32 Very High Very High Very High
Stress 104 98.32 Very High Very High Very High
Drug Induced Neurotoxicity 7 98.28 Very High Very High Very High
Congenital Anomalies 13 97.12 Very High Very High Very High
Drug Dependence 4 96.32 Very High Very High Very High
Morphine Dependence 8 95.08 Very High Very High Very High
Nervous System Injury 85 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we assessed (i) the regulation of GLT-1 expression in the spinal cord after peripheral nociceptive stimulation and (ii) the nociceptive behavior of rats following inhibition or transient knockdown of spinal GLT-1.
Regulation (regulation) of Gene_expression (expression) of GLT-1 in spinal cord associated with nociception and spinal cord
1) Confidence 0.62 Published 2003 Journal Neuroscience Section Abstract Doc Link 12535941 Disease Relevance 0.49 Pain Relevance 0.29
In cultured astrocytes, the expression of GLT-1 mRNA was regulated by agents activating the cAMP pathway, as well as beta-adrenergic agonist and dopamine, but not morphine.
Regulation (regulated) of Gene_expression (expression) of GLT-1 mRNA in astrocytes associated with dopamine, agonist and morphine
2) Confidence 0.61 Published 2001 Journal Yakugaku Zasshi Section Abstract Doc Link 11558151 Disease Relevance 0.13 Pain Relevance 1.66
Finally, no expression or change in expression of GLT-1 or GLAST was observed in neurons.
Neg (no) Regulation (change) of Gene_expression (expression) of GLT-1 in neurons
3) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0 Pain Relevance 0.22
Effect of gene transfer of GLT-1, a glutamate transporter, into the locus coeruleus by recombinant adenoviruses on morphine physical dependence in rats.
Regulation (Effect) of Gene_expression (transfer) of GLT-1 in locus coeruleus associated with glutamate, physical dependence, locus ceruleus and morphine
4) Confidence 0.45 Published 2004 Journal Eur. J. Neurosci. Section Title Doc Link 14750980 Disease Relevance 0.42 Pain Relevance 1.40
Changes in the expression of glial glutamate transporters (GLAST and GLT-1) were examined in the spinal cord of rats with chemotherapy (taxol)-induced mechanical hyperalgesia.
Regulation (Changes) of Gene_expression (expression) of GLT-1 in spinal cord associated with hyperalgesia, glutamate, taxol and spinal cord
5) Confidence 0.44 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15975716 Disease Relevance 0.25 Pain Relevance 0.63
Effect of spinal gene transfer of GLT-1 on inflammatory hyperalgesia
Regulation (Effect) of Gene_expression (transfer) of GLT-1 in spinal associated with hyperalgesia and inflammation
6) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 0.90 Pain Relevance 0.38
Using the recombinant adenoviruses, we showed that gene transfer of GLT-1 into the spinal cord had no effect on the acute nociceptive responses to mechanical and thermal stimuli in naive rats.
Neg (no) Regulation (effect) of Gene_expression (transfer) of GLT-1 in spinal cord associated with nociception and spinal cord
7) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 0.66 Pain Relevance 0.48
To investigate the effect of spinal gene transfer of GLT-1 on the induction of neuropathic pain following partial sciatic nerve ligation (pSNL), we performed pSNL 7 days after the intraspinal infusion of the adenoviruses (Fig. 4).
Spec (investigate) Regulation (effect) of Gene_expression (transfer) of GLT-1 in sciatic nerve associated with neuropathic pain and sciatic nerve
8) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 0.94 Pain Relevance 0.77
Effect of spinal gene transfer of GLT-1 on neuropathic pain
Regulation (Effect) of Gene_expression (transfer) of GLT-1 in spinal associated with neuropathic pain
9) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 0.90 Pain Relevance 0.71
To further determine whether the above anti-nociceptive effects of Cef are a result of the up-regulation of spinal GLT-1 expression and its function, we further observed the effects of intrathecal administration of Cef in the same model.
Spec (whether) Regulation (regulation) of Gene_expression (expression) of GLT-1 in spinal associated with nociception and intrathecal
10) Confidence 0.42 Published 2010 Journal Pain Section Abstract Doc Link 20022427 Disease Relevance 1.16 Pain Relevance 1.09
It was found that intrathecal administration of Cef led to the specific up-regulation of GLT-1 expression and glutamate uptake ((3)H-glutamate) in the spinal dorsal horn, and similar anti-nociceptive effects to those of intraperitoneal administration of Cef.
Regulation (regulation) of Gene_expression (expression) of GLT-1 in dorsal horn associated with nociception, glutamate, spinal dorsal horn and intrathecal
11) Confidence 0.42 Published 2010 Journal Pain Section Abstract Doc Link 20022427 Disease Relevance 1.07 Pain Relevance 1.03
These results indicate that Cef plays an anti-nociceptive role by up-regulating spinal GLT-1 expression and its function.
Regulation (regulating) of Gene_expression (expression) of GLT-1 in spinal associated with nociception
12) Confidence 0.42 Published 2010 Journal Pain Section Abstract Doc Link 20022427 Disease Relevance 0.70 Pain Relevance 0.73
This long-term hyperalgesia was accompanied by significant down-regulation of GLT-1 expression in the L4-L6 segments of the spinal dorsal horn, as revealed by immunohistochemistry and Western blot.
Regulation (regulation) of Gene_expression (expression) of GLT-1 in dorsal horn associated with hyperalgesia and spinal dorsal horn
13) Confidence 0.42 Published 2010 Journal Pain Section Abstract Doc Link 20022427 Disease Relevance 1.19 Pain Relevance 0.95
Given the key role played by uptake processes in glutamate neurotransmission, this study examined the effects of nigrostriatal deafferentation and of levodopa treatment on the striatal expression of the glutamate transporters GLT1, GLAST and EAAC1 in the rat.
Spec (examined) Regulation (effects) of Gene_expression (expression) of GLT1 associated with glutamate and deafferentation
14) Confidence 0.41 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11723182 Disease Relevance 0.09 Pain Relevance 0.23
The present study examined the role of nuclear transcription factor-kappaB (NF-kappaB) in the regulation of the expression of GLAST, GLT-1, and EAAC1 following long-term amitriptyline/morphine co-infusion.
Spec (examined) Regulation (role) of Gene_expression (expression) of GLT-1 associated with endep and morphine
15) Confidence 0.39 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.25
These results suggest that the changes of GLT-1 expression, which alter the glutamate uptake and affect the glutamatergic transmission efficiency, play a role in the development of morphine dependence and the expression of morphine withdrawal.
Regulation (changes) of Gene_expression (expression) of GLT-1 associated with addiction, glutamate, withdrawal and morphine
16) Confidence 0.27 Published 2001 Journal Yakugaku Zasshi Section Abstract Doc Link 11558151 Disease Relevance 0.22 Pain Relevance 1.62
These findings support the idea that altered expression or function of GLT-1 in the spinal cord contributes to the pathogenesis of inflammatory and neuropathic pain.
Regulation (altered) of Gene_expression (expression) of GLT-1 in spinal cord associated with inflammation, neuropathic pain and spinal cord
17) Confidence 0.26 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 1.36 Pain Relevance 1.49
Although we did not determine the influence of GLT-1 gene transfer in motor neurons in this study, at least, it did not induce behavioral abnormalities and abnormal gait, and had no effect on the escape behaviors from the mechanical and thermal nociceptive stimuli.
Spec (determine) Regulation (influence) of Gene_expression (transfer) of GLT-1 gene in motor neurons associated with nociception and congenital anomalies
18) Confidence 0.26 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 0.48 Pain Relevance 0.28
These data provide the first evidence that levodopa therapy may interfere with striatal glutamate transmission through change in expression of the primarily glial glutamate transporter GLT1.
Regulation (change) of Gene_expression (expression) of GLT1 associated with glutamate
19) Confidence 0.24 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11723182 Disease Relevance 0.06 Pain Relevance 0.31
The present study examined the role of nuclear transcription factor-kappaB (NF-kappaB) in the regulation of the expression of GLAST, GLT-1, and EAAC1 following long-term amitriptyline/morphine co-infusion.
Regulation (regulation) of Gene_expression (expression) of GLT-1 associated with endep and morphine
20) Confidence 0.17 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.23

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