INT98111

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 10.85
Pain Relevance 9.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
neurons 2
dorsal root ganglion 2
DA neurons 1
CSF 1
spinal cords 1
Gdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 1 99.90 Very High Very High Very High
Somatostatin 12 99.80 Very High Very High Very High
Neuropeptide 5 99.66 Very High Very High Very High
Spinal cord 58 99.60 Very High Very High Very High
Pain 60 99.38 Very High Very High Very High
Lasting pain 7 99.36 Very High Very High Very High
Migraine 14 98.96 Very High Very High Very High
Causalgia 1 98.92 Very High Very High Very High
Inflammation 26 98.68 Very High Very High Very High
headache 7 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 7 99.92 Very High Very High Very High
Pain 56 99.38 Very High Very High Very High
Headache 20 98.96 Very High Very High Very High
Causalgia 1 98.92 Very High Very High Very High
INFLAMMATION 44 98.68 Very High Very High Very High
Nociception 27 98.16 Very High Very High Very High
Arthritis 3 97.60 Very High Very High Very High
Ganglion Cysts 3 96.60 Very High Very High Very High
Schizophrenia 220 96.36 Very High Very High Very High
Fibromyalgia 6 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that GDNF was down-regulated in both dorsal root ganglia and spinal cords 2 weeks after arthritis induction.
Negative_regulation (down-regulated) of GDNF in dorsal root ganglia associated with arthritis
1) Confidence 0.59 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617957 Disease Relevance 1.00 Pain Relevance 1.06
The effect of this antibody coincided with the down-regulation of GDNF immunoreactivity in response to inflammation, suggesting that GDNF supports biochemical changes that contribute to hyperalgesia.
Negative_regulation (down-regulation) of GDNF associated with hyperalgesia and inflammation
2) Confidence 0.43 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617957 Disease Relevance 1.11 Pain Relevance 1.04
However, the locomotion function in the hindlimbs decreased effectively in GDNF-antibody treated rats.
Negative_regulation (decreased) of GDNF in hindlimbs
3) Confidence 0.43 Published 2007 Journal Neurochem Res Section Abstract Doc Link PMC2270371 Disease Relevance 0.25 Pain Relevance 0.04
Also, the neuropeptide substance P and glial cell line-derived neurotrophic factor and its receptor significantly decreased (p < 0.02) with increasing load in the small nociceptive neurons of the dorsal root ganglion, suggesting that axonal damage may also decrease neurotrophic support in injured nociceptive afferent fibers.
Negative_regulation (decreased) of glial cell line-derived neurotrophic factor in dorsal root ganglion associated with ganglion cysts, nociception, dorsal root ganglion, neuropeptide and substance p
4) Confidence 0.37 Published 2008 Journal Stapp Car Crash J Section Abstract Doc Link 19085157 Disease Relevance 1.18 Pain Relevance 0.72
GDNF levels decreased in ipsilateral DRG, whereas the constriction did not modify its expression in the central nervous system districts.
Negative_regulation (decreased) of GDNF in central nervous system associated with central nervous system
5) Confidence 0.34 Published 2010 Journal Neuroscience Section Abstract Doc Link 20302919 Disease Relevance 1.25 Pain Relevance 1.03
The comparison of histograms of treated and untreated neurons allowed the definition of NGF and GDNF responsive neurons.
Negative_regulation (definition) of GDNF in neurons
6) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0 Pain Relevance 0
We found that GDNF was down-regulated in both dorsal root ganglia and spinal cords 2 weeks after arthritis induction.
Negative_regulation (down-regulated) of GDNF in spinal cords associated with arthritis
7) Confidence 0.20 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617957 Disease Relevance 1.00 Pain Relevance 1.06
Our findings suggest that TPS neurons should be particularly sensitive to GDNF, LIF, and CNTF during the first week p.i., and these are the growth factors most likely to be effective in protecting TPS neurons from apoptosis and maintaining a regenerative response within a CNS environment.
Negative_regulation (sensitive) of GDNF in neurons associated with apoptosis
8) Confidence 0.13 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.44 Pain Relevance 0.23
Glial cell lineĀ–derived neurotrophic factor (GDNF) may play a role in schizophrenia as certain GDNF alleles appear to protect against schizophrenia.216 GDNF, a dopaminergic neuron development factor, protects DA neurons from toxic effects of amphetamine in animal models.217 Chronic and prenatal BPA exposures both significantly decrease GDNF.175

Galanin.

Negative_regulation (decrease) of GDNF in DA neurons associated with dopamine and schizophrenia
9) Confidence 0.11 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.41 Pain Relevance 0.14
Pain was associated with levels of GDNF that were increased intrathecally, but decreased in blood.
Negative_regulation (decreased) of GDNF in blood associated with pain
10) Confidence 0.07 Published 2010 Journal J. Neuroimmunol. Section Abstract Doc Link 20129677 Disease Relevance 0.69 Pain Relevance 0.84
Based on experimental findings, it can be postulated that reduced CSF levels of GDNF and somatostatin in both CM and PCM + PAAH patients can contribute to sustained central sensitization underlying chronic head pain.
Negative_regulation (reduced) of GDNF in CSF associated with central sensitization, migraine, somatostatin and headache
11) Confidence 0.06 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16556241 Disease Relevance 2.09 Pain Relevance 2.57
While further studies are required, these findings suggest that accumulation of SNS/PN3 and/or loss of GDNF may contribute to pain in causalgia, and that selective blockers of SNS/PN3 and/or rhGDNF may provide effective novel treatments.
Negative_regulation (loss) of GDNF associated with pain and causalgia
12) Confidence 0.05 Published 2001 Journal Eur J Pain Section Abstract Doc Link 11558987 Disease Relevance 0.44 Pain Relevance 0.56

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