INT98131

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Context Info
Confidence 0.31
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.28
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNFRSF1A) extracellular region (TNFRSF1A) plasma membrane (TNFRSF1A)
nucleus (TNFRSF1A) protein complex (TNFRSF1A)
TNFRSF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
visual analogue scale 2 99.40 Very High Very High Very High
Pain 8 98.52 Very High Very High Very High
Inflammation 47 98.16 Very High Very High Very High
cytokine 8 94.72 High High
Inflammatory response 1 90.56 High High
rheumatoid arthritis 65 85.52 High High
cINOD 2 73.28 Quite High
Inflammatory mediators 5 11.84 Low Low
Arthritis 19 5.00 Very Low Very Low Very Low
imagery 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 11 100.00 Very High Very High Very High
Necrosis 8 100.00 Very High Very High Very High
Synovitis 90 99.92 Very High Very High Very High
Apoptosis 18 99.44 Very High Very High Very High
Pain 5 98.52 Very High Very High Very High
INFLAMMATION 56 98.16 Very High Very High Very High
Obesity 117 96.80 Very High Very High Very High
Reprotox - General 1 3 96.72 Very High Very High Very High
Death 6 90.24 High High
Pulmonary Disease 47 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein encoded by tumor necrosis factor receptor superfamily 1A (TNFRSF1A) gene is one of the major receptors in TNF-?
Regulation (encoded) of TNFRSF1A associated with necrosis and cancer
1) Confidence 0.31 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 2.57 Pain Relevance 0.37
Sulindac sulfide specifically up-regulated the DR5 levels but had no effect on the levels of other DRs including DR4, Fas, and tumor necrosis factor receptor 1.
Neg (no) Regulation (effect) of tumor necrosis factor receptor 1 associated with necrosis and cancer
2) Confidence 0.17 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11559570 Disease Relevance 1.78 Pain Relevance 0.07
Changes in RI following treatment with anti-tumour necrosis factor (anti-TNF) have also been demonstrated [18].
Regulation (Changes) of RI associated with necrosis and cancer
3) Confidence 0.02 Published 2007 Journal Skeletal Radiol Section Body Doc Link PMC2141652 Disease Relevance 0.61 Pain Relevance 0.24
Changes in RI can also be induced by increasing probe pressure and by changes in temperature.
Regulation (Changes) of RI
4) Confidence 0.02 Published 2007 Journal Skeletal Radiol Section Body Doc Link PMC2141652 Disease Relevance 0.17 Pain Relevance 0
Therefore, comparable values of PA in the two groups linked the resulting values of RI and ERI to the measures of F1Amp and E1Amp, respectively (RI and ERI indexes were computed from the ratio of F1Amp and E1Amp to the PA; see Methods).


Regulation (values) of RI
5) Confidence 0.01 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693559 Disease Relevance 0.15 Pain Relevance 0.07

General Comments

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