INT98134

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Context Info
Confidence 0.39
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 11.45
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAX) cytosol (BAX) mitochondrion (BAX)
endoplasmic reticulum (BAX) nucleus (BAX) cytoplasm (BAX)
Anatomy Link Frequency
endothelial cells 1
pore 1
BAX (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 23 93.24 High High
cINOD 48 92.44 High High
dexamethasone 63 86.96 High High
vincristine 2 80.88 Quite High
Ventral tegmentum 2 80.80 Quite High
antagonist 63 79.60 Quite High
Substantia nigra 18 76.84 Quite High
Restless leg syndrome 1 76.72 Quite High
Catecholamine 2 76.00 Quite High
Dopamine 6 68.64 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 1014 99.66 Very High Very High Very High
Stress 30 97.68 Very High Very High Very High
Death 210 95.48 Very High Very High Very High
Chronic Lymphoid Leukemia 11 94.60 High High
Cv Unclassified Under Development 22 93.24 High High
INFLAMMATION 111 92.24 High High
Cv General 4 Under Development 1 91.36 High High
Colon Cancer 87 89.72 High High
Pancreatic Cancer 33 89.08 High High
Cancer 518 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Short peptides representing alpha-helical BH3 domains of Bid or Bim are capable of inducing oligomerization of Bak and Bax to release cytochrome c.
Bax Binding (oligomerization) of
1) Confidence 0.39 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.73 Pain Relevance 0
G(2)-M arrest was associated with phosphorylation of Bcl2 (but not BAD, Bax, or Bcl-XL): both of these end points were abrogated by treatment with a calcium chelator.
Bax Binding (associated) of
2) Confidence 0.36 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12384529 Disease Relevance 0.80 Pain Relevance 0.12
Our findings are consistent with the hypothesis that alterations in bax: bcl-2 ratio with exercise regulate downstream caspase-driven apoptosis during the exercise.
bax Binding (alterations) of associated with apoptosis
3) Confidence 0.36 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.51 Pain Relevance 0
Cells from mice deficient for both Bax and Bak, but not cells deficient for one or the other only, are almost completely resistant to mitochondria-mediated apoptosis [37], suggesting that these proteins have redundant functions in this pathway.
Bax Binding (deficient) of associated with apoptosis
4) Confidence 0.35 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 0.70 Pain Relevance 0.16
The antibody we used in this investigation could recognize 21 kD Bax?
Bax Binding (recognize) of
5) Confidence 0.29 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 0.48 Pain Relevance 0.18
Survivin expression was not associated with p53 or Bax expression (p = 0.9969 and 0.0931, respectively, Table 4)

Survivin, p53, and bax expression and clinico-pathologic characteristics

Bax Binding (associated) of
6) Confidence 0.29 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1266027 Disease Relevance 0.32 Pain Relevance 0
Recent evidence suggests that sulindac sulfide engages the mitochondrial pathway involving caspase 9 and Bax to mediate its apoptotic effects [Zhang et al., Science (Wash.
Bax Binding (engages) of associated with apoptosis
7) Confidence 0.24 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11559570 Disease Relevance 0.99 Pain Relevance 0.09
Cleaved caspase-8 is involved in initiating the extrinsic pathway, while BAX polymerization mediates mitochondrial cytochrome c release as an early step in the intrinsic pathway (Riedl and Shi, 2004).
BAX Binding (polymerization) of
8) Confidence 0.17 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0.41 Pain Relevance 0.15
A second hypothesis is that upon activation, pro-apoptotic members such as Bax and Bak are inserted into the outer mitochondrial membrane where they oligomerize to form a protein-permeant pore of their own (Mattson and Kroemer 2003).
Bax Binding (oligomerize) of in pore associated with apoptosis
9) Confidence 0.15 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 0.85 Pain Relevance 0.11
We identified dying cells by the presence of cleaved caspase-8, cleaved caspase-3, and oligomerized BAX (Figures 4A–4F).
BAX Binding (oligomerized) of
10) Confidence 0.15 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0.66 Pain Relevance 0
Anti-rabbit Bcl-2, Bid, Bax, cytochrome c, and ?
Bax Binding (rabbit) of
11) Confidence 0.15 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.33 Pain Relevance 0
Increase in cyclic AMP and decrease in TNF-alpha levels were identified in the ipsilateral cortex under treatment with cilostazol accompanied by decreased Bax formation and cytochrome c release with increased Bcl-2 production in the penumbral area as well as in the in vitro human umbilical endothelial cells.
Bax Binding (formation) of in endothelial cells
12) Confidence 0.13 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 16472148 Disease Relevance 0.62 Pain Relevance 0.12
The interaction between Bax/Bak and the Bcl-2 family anti-apoptotic members is carefully regulated by the BH-3-only proteins.
Bax Binding (interaction) of associated with apoptosis
13) Confidence 0.13 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.01 Pain Relevance 0
Bax can form also a complex with the anti-apoptotic protein Bcl-xL [53] and Mcl-1 [14].
Bax Binding (complex) of associated with apoptosis
14) Confidence 0.13 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.08 Pain Relevance 0
proapoptotic molecules such as Bax and Bak through heterodimerization through
Bax Binding (heterodimerization) of
15) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.67 Pain Relevance 0
BH3 domain binding which inhibits the proapoptotic function of Bax and Bak [43, 44].
Bax Binding (binding) of
16) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.80 Pain Relevance 0
Under normal conditions, Bax is constitutively associated with ly-XL.
Bax Binding (associated) of
17) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.50 Pain Relevance 0

General Comments

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