INT98148

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 11.71
Pain Relevance 5.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lymph nodes 2
joints 1
band 1
ankle 1
T cells 1
IL17 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 286 100.00 Very High Very High Very High
rheumatoid arthritis 211 99.40 Very High Very High Very High
Inflammation 263 99.36 Very High Very High Very High
Neuritis 15 99.08 Very High Very High Very High
Multiple sclerosis 45 98.56 Very High Very High Very High
Arthritis 572 98.52 Very High Very High Very High
imagery 22 96.12 Very High Very High Very High
Sciatic nerve 3 95.44 Very High Very High Very High
Cannabinoid receptor 1 89.76 High High
complementary and alternative medicine 123 88.64 High High
Disease Link Frequency Relevance Heat
Necrosis 10 100.00 Very High Very High Very High
Cancer 7 100.00 Very High Very High Very High
Diabetes Mellitus 68 99.84 Very High Very High Very High
Immunization 35 99.70 Very High Very High Very High
Inflammatory Bowel Disease 21 99.56 Very High Very High Very High
Rheumatoid Arthritis 214 99.40 Very High Very High Very High
INFLAMMATION 268 99.36 Very High Very High Very High
Autoimmune Disease 117 99.18 Very High Very High Very High
Experimental Autoimmune Neuritis 15 99.08 Very High Very High Very High
Multiple Sclerosis 91 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to explore indirect influence of MP on IL-17 production, which could be important for the observed difference in efficiency of MP in inhibition of IL-17 in purified T cells and LNC, CD3- cells were stimulated with LPS in the presence or absence of MP and production of a major IL-17-promoting cytokine – IL-6 was determined.
Negative_regulation (inhibition) of IL-17 in T cells associated with cytokine
1) Confidence 0.49 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.05
FTY720, which has been shown to reduce severity of EAN, attenuated accumulation of IL-17(+) cells in sciatic nerves, decreased IL-17(+) cell proportion in peripheral blood, but increased IL-17(+) cell proportion in lymph nodes, suggesting the involvement of S1P signal pathway in regulating IL-17(+) cell trafficking.
Negative_regulation (decreased) of IL-17 in lymph nodes
2) Confidence 0.42 Published 2009 Journal Neuropathol. Appl. Neurobiol. Section Body Doc Link 19207263 Disease Relevance 0.08 Pain Relevance 0
, even in a minute quantity that persisted after MP inhibition was a negative regulator of IL-17 in our experimental system, and that it cooperated with MP in reduction of IL-17 generation in LNC.


Negative_regulation (regulator) of IL-17
3) Confidence 0.36 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.04
Our results suggest that a part of the efficiency of GCs in the therapy of MS, and other autoimmune diseases such as RA and IBD, is achieved through reduction of IL-17 generation.
Negative_regulation (reduction) of IL-17 associated with inflammatory bowel disease, multiple sclerosis, autoimmune disease and rheumatoid arthritis
4) Confidence 0.36 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 1.09 Pain Relevance 0.30
matched with the concurrent reduction in IL-17.
Negative_regulation (reduction) of IL-17
5) Confidence 0.27 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958519 Disease Relevance 0.52 Pain Relevance 0.45
Bone preservation appeared to be one of the main benefits of IL-17 inhibition, and this feature was reflected in the ankle bone volumes calculated quantitatively by micro-CT imaging.
Negative_regulation (inhibition) of IL-17 in ankle associated with imagery
6) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 0.85 Pain Relevance 0.45
Furthermore, HLXL feeding suppressed the proinflammatory IL-17 (Figure 2(b)) (P < .01), but increased both the anti-inflammatory IL-10 (Figure 2(d)) and the proinflammatory IFN-?
Negative_regulation (suppressed) of IL-17 associated with inflammation
7) Confidence 0.20 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958519 Disease Relevance 0.62 Pain Relevance 0.37
Notably, HLXL feeding caused suppression of the proinflammatory cytokines IL-17 and IL-1?
Negative_regulation (suppression) of IL-17 associated with cytokine
8) Confidence 0.20 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958519 Disease Relevance 0.93 Pain Relevance 0.55
RESULTS: Asimadoline significantly decreased arthritis severity at day 13, with a concomitant decrease in synovial membrane expression of cytokines interleukin-17 and transforming growth factor-beta (TGF-beta) mRNA at day 13, and no change in T cell numbers in the joints of arthritic rats.
Negative_regulation (decrease) of cytokines interleukin-17 in joints
9) Confidence 0.17 Published 2001 Journal Rheumatology (Oxford) Section Body Doc Link 11561112 Disease Relevance 0.08 Pain Relevance 0
These effects correlated with inhibition of both IL-17 and IL-6 which, in addition to TNF-?
Negative_regulation (inhibition) of IL-17
10) Confidence 0.12 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 1.42 Pain Relevance 0.65
The in vivo blockade of IL-17 by soluble IL-17 receptors or by neutralizing anti-IL-17 antibody can significantly attenuate arthritis in rodents [126].
Negative_regulation (blockade) of IL-17 associated with arthritis
11) Confidence 0.11 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC3014691 Disease Relevance 0.98 Pain Relevance 0.52
Importantly, feeding rats with green tea [33] or HLXL [34] led to a significant reduction in IL-17 response.
Negative_regulation (reduction) of IL-17
12) Confidence 0.11 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC3014691 Disease Relevance 0.76 Pain Relevance 0.41
VPA (300 mg/kg, intraperitoneally) administration to EAN rats once daily immediately following immunization significantly suppressed mRNA levels of interferon-gamma, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-4, IL-6 and IL-17 in the lymph nodes of EAN rats.
Negative_regulation (suppressed) of IL-17 in lymph nodes associated with necrosis, cancer, immunization and neuritis
13) Confidence 0.10 Published 2008 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 18953683 Disease Relevance 1.38 Pain Relevance 1.01
Fgf2, haptoglobin, and IL-4 levels were elevated in diabetic animals, while IL-17 levels were significantly decreased in diabetic levels.
Negative_regulation (decreased) of IL-17 associated with diabetes mellitus
14) Confidence 0.09 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.84 Pain Relevance 0.04
CP-690,550 treatment dose-dependently decreased both IL-17 and IL-6 showing an approximately 80% inhibition of the AIA-induced increase compared to control levels (Figures 2E).
Negative_regulation (decreased) of IL-17 associated with arthritis
15) Confidence 0.09 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.69 Pain Relevance 0.20
Furthermore, mice deficient in IL-17 [127] or IL-17 receptor [128] were found to be resistant to the induction of CIA.
Negative_regulation (deficient) of IL-17 associated with arthritis
16) Confidence 0.08 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC3014691 Disease Relevance 0.90 Pain Relevance 0.45
The levels of pro-inflammatory cytokines interferon-gamma and interleukin-17 were strongly diminished.
Negative_regulation (diminished) of interleukin-17 associated with inflammation and cytokine
17) Confidence 0.07 Published 2010 Journal Brain Section Abstract Doc Link PMC2892943 Disease Relevance 0.42 Pain Relevance 0.29
A 360 kb loss in band 6p12.3, containing the genes RHAG, CRISP1, 2, and 3, and PGK2, a 1.15 Mb loss in 6p12.2-p12.1, containing the genes PKHD1, IL17, MCM3, EFHC1, and TRAM2 genes, and an 11.9 Mb loss in region 6q14.3-q16.1, reported previously, were mapped on the rearranged chromosome 6.
Negative_regulation (loss) of IL17 in band
18) Confidence 0.04 Published 2009 Journal Eur J Med Genet Section Abstract Doc Link 19041736 Disease Relevance 0.16 Pain Relevance 0.20

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