INT9817

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Context Info
Confidence 0.05
First Reported 1991
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Pdia4) endoplasmic reticulum (Pdia4)
Pdia4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 3 99.52 Very High Very High Very High
Kappa opioid receptor 3 99.40 Very High Very High Very High
imagery 1 90.36 High High
Kinase C 1 89.44 High High
antagonist 2 84.20 Quite High
Opioid 1 75.00 Quite High
Delta opioid receptors 1 52.60 Quite High
lidocaine 1 41.52 Quite Low
Analgesic 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation with the muscarinic agonist carbachol (100 microM) caused a clearly biphasic intracellular calcium (Cai) response: Cai was stimulated from resting levels (85 +/- 3 nM, n = 100) to a sudden transient peak (821 +/- 44 nM) followed by a sustained plateau (317 +/- 12 nM).
Positive_regulation (caused) of Positive_regulation (stimulated) of Cai associated with agonist
1) Confidence 0.05 Published 1992 Journal Pflugers Arch. Section Abstract Doc Link 1437524 Disease Relevance 0 Pain Relevance 0.13
Thus an acute and brief kappa-opioid receptor stimulation of cardiac cells leads to an increase in Cai and pHi.
Positive_regulation (leads) of Positive_regulation (increase) of Cai associated with kappa opioid receptor
2) Confidence 0.03 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1659231 Disease Relevance 0 Pain Relevance 0.38

General Comments

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