INT98176

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Context Info
Confidence 0.33
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.85
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleolus (Casp3) nucleus (Casp3) intracellular (Casp3)
Anatomy Link Frequency
cleavage 6
neurons 2
nerve 2
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 312 100.00 Very High Very High Very High
Paracetamol 14 99.00 Very High Very High Very High
Sciatic nerve 6 98.60 Very High Very High Very High
adenocard 1 91.52 High High
Hippocampus 14 84.24 Quite High
Demyelination 1 80.96 Quite High
Hyperalgesia 5 76.60 Quite High
antagonist 27 76.08 Quite High
diabetic neuropathy 6 75.00 Quite High
metalloproteinase 3 71.36 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 287 100.00 Very High Very High Very High
Death 202 99.72 Very High Very High Very High
Diabetes Mellitus 67 99.40 Very High Very High Very High
Neurodegenerative Disease 31 98.80 Very High Very High Very High
Toxicity 15 97.80 Very High Very High Very High
Convulsion 134 95.20 Very High Very High Very High
Necrosis 4 93.32 High High
Demyelinating Disease 1 80.96 Quite High
Sprains And Strains 1 80.92 Quite High
Stress 35 80.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, activation of calpain precedes that of caspase-3, glutamate-induced LDH release (cell death) and DNA fragmentation in these cells.
Positive_regulation (induced) of Localization (release) of caspase-3 associated with glutamate and death
1) Confidence 0.33 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 1.34 Pain Relevance 0.32
Taken together, these findings indicate that the proteolytic cleavage of caspase-3 into active caspase-3 fragments is induced by PTZ and ethanol exposure during pregnancy.


Positive_regulation (induced) of Localization (cleavage) of caspase-3 in cleavage
2) Confidence 0.28 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.59 Pain Relevance 0.04
Taken together, these findings indicate that the proteolytic cleavage of caspase-3 into active caspase-3 fragments is induced by PTZ and ethanol exposure during pregnancy.


Positive_regulation (induced) of Localization (cleavage) of caspase-3 in cleavage
3) Confidence 0.28 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.59 Pain Relevance 0.04
Cytochrome c release and active caspase 3 were markedly increased in nerve from diabetic animals suggesting activation of apoptotic pathway.
Positive_regulation (increased) of Localization (release) of caspase 3 in nerve associated with diabetes mellitus and apoptosis
4) Confidence 0.25 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 19840221 Disease Relevance 1.67 Pain Relevance 0.50
Effect of estrogens on the activation of calpain and caspase-3
Positive_regulation (activation) of Localization (calpain) of caspase-3
5) Confidence 0.24 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 0.62 Pain Relevance 0.15
exerts potent proapoptotic effects in cardiomyocytes in vitro and in the myocardium in vivo, characterized by the activation of caspase-3 and the cleavage of PARP.
Positive_regulation (activation) of Localization (cleavage) of caspase-3 in cleavage
6) Confidence 0.19 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570581 Disease Relevance 0.71 Pain Relevance 0.08
M) did not induce any cytotoxic effect but attenuated the stauro-sporine-induced caspase-3 activity and LDH release in hippocampal cultured neurons in vitro [111].
Positive_regulation (induced) of Localization (release) of caspase-3 in neurons
7) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.29 Pain Relevance 0.10
AAP-induced apoptosis was preceded by the sequential elevation of the pro-apoptotic Bax protein, cytochrome c release, and caspase-3 activity.
Positive_regulation (elevation) of Localization (release) of caspase-3 associated with paracetamol and apoptosis
8) Confidence 0.02 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11562448 Disease Relevance 1.04 Pain Relevance 0.89

General Comments

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