INT9821

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Context Info
Confidence 0.33
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.32
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Bcl2a1a)
Anatomy Link Frequency
endothelial cells 1
brain 1
striatum 1
Bcl2a1a (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 116 100.00 Very High Very High Very High
Opioid 95 99.68 Very High Very High Very High
cannabis 30 99.52 Very High Very High Very High
alcohol 16 99.48 Very High Very High Very High
addiction 111 99.20 Very High Very High Very High
Lasting pain 1 95.84 Very High Very High Very High
agonist 17 95.28 Very High Very High Very High
antagonist 21 94.56 High High
Inflammation 34 93.96 High High
Dopamine 25 90.76 High High
Disease Link Frequency Relevance Heat
Opiate Addiction 120 99.48 Very High Very High Very High
Alcohol Addiction 5 99.48 Very High Very High Very High
Nicotine Addiction 10 98.04 Very High Very High Very High
Adult Respiratory Distress Syndrome 61 97.72 Very High Very High Very High
Drug Dependence 70 95.92 Very High Very High Very High
Pain 4 95.84 Very High Very High Very High
Injury 52 94.96 High High
INFLAMMATION 24 93.96 High High
Pneumonia 20 92.64 High High
Increased Venous Pressure Under Development 4 83.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that BCL2 or BCL2A1 protein engages a co-receptor and that co-operative signaling by this receptor and TLR2 (engaged by endogenous ligands generated with tissue injury) promotes cytoprotection.
BCL2A1 Binding (engages) of associated with injury
1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816997 Disease Relevance 0.48 Pain Relevance 0.18
The drugs chosen were, R-phenylisopropyl-adenosine (R-PIA) with high affinity for the A1 receptor, N-ethylcarboxamide-adenosine (NECA) with almost equal affinity for the A1 and A2 receptor and 2-(2-aminoethylamino)-carbonylethylphenylethylamino-adenosin e (APEC) with high affinity for the A2 receptor.
A1 Binding (affinity) of associated with adenocard
2) Confidence 0.33 Published 1992 Journal Pharmacol. Toxicol. Section Abstract Doc Link 1438021 Disease Relevance 0.25 Pain Relevance 0.66
The A1 allele is associated with a reduction in the density of D2 receptors at the striatum [8-10], although one study failed to replicate this finding [11].
A1 Binding (associated) of in striatum
3) Confidence 0.22 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1892032 Disease Relevance 0.73 Pain Relevance 0.43
1) The associations found could be related more to the progression and severity of heroin dependence than vulnerability to this disorder [28], because patients had a long history of heroin use; 2) Type II error is a potential explanation for our findings, since the differences detected did not reach the significance threshold (i.e.: P < 0.008) when the Bonferroni correction was applied to the six genetic comparisons performed (Tables 2 and 3); however, type II error could occur in any direction (i.e., either A1 or A2 could have been associated with heroin use), while we found that the associated allele was A1, just as in previous reports; 3) The male-limited association of A1 allele with heroin dependence must be considered as a preliminary finding, because more males than females participated in the present study and there is no indication of gender dimorphism in regard with the TaqI A alleles in the literature; 4) The findings of the present study may not be generalizable, because all study participants belonged to the same population.
A1 Binding (association) of associated with addiction and opiate addiction
4) Confidence 0.22 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1892032 Disease Relevance 0.57 Pain Relevance 0.27
However, in the particular case of opioid use disorders, associations with the A1 allele have been found in some studies [17,18], but not in others [19,20].
A1 Binding (associations) of associated with opioid
5) Confidence 0.21 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1892032 Disease Relevance 0.40 Pain Relevance 0.42
Male-limited associations of the DRD2 A1 allele with alcohol dependence [26] and tobacco smoking [27] have been reported previously.
A1 Binding (associations) of associated with addiction, nicotine addiction and alcohol
6) Confidence 0.19 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1892032 Disease Relevance 0.40 Pain Relevance 0.50
However, associations between the DRD2 A1 allele and cannabis use disorders have not been published.
A1 Binding (associations) of associated with cannabis
7) Confidence 0.19 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1892032 Disease Relevance 0.45 Pain Relevance 0.62
In low doses, which are the most relevant to human use, caffeine effects are exerted by antagonizing brain adenosine A1 and A2A receptors with secondary effects on dopaminergic neurotransmission [1].
A1 Binding (antagonizing) of in brain associated with adenocard
8) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0.32 Pain Relevance 0.14
Interestingly, LPS has been shown to be a ligand for A1 on human pulmonary endothelial cells.
A1 Binding (ligand) of in endothelial cells
9) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.72 Pain Relevance 0.24

General Comments

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