INT9822

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Context Info
Confidence 0.36
First Reported 1992
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 3.00
Pain Relevance 3.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Agtr2) plasma membrane (Agtr2) transcription factor binding (Agtr2)
signal transducer activity (Agtr2)
Anatomy Link Frequency
eye 1
brain 1
spleen 1
podocytes 1
Agtr2 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 34 100.00 Very High Very High Very High
Endogenous opioid 1 99.76 Very High Very High Very High
antagonist 14 99.02 Very High Very High Very High
agonist 12 98.70 Very High Very High Very High
opioid receptor 7 98.52 Very High Very High Very High
narcan 3 98.16 Very High Very High Very High
Lasting pain 2 95.84 Very High Very High Very High
Antinociceptive 24 95.04 Very High Very High Very High
Inflammation 14 94.48 High High
member 8 1 92.00 High High
Disease Link Frequency Relevance Heat
Nociception 2 100.00 Very High Very High Very High
Apoptosis 17 99.72 Very High Very High Very High
Diabetes Mellitus 65 99.68 Very High Very High Very High
Natriuresis 1 98.68 Very High Very High Very High
Pain 4 95.84 Very High Very High Very High
INFLAMMATION 22 94.48 High High
Adhesions 20 90.80 High High
Hypothermia 1 88.40 High High
Drug Dependence 2 85.76 High High
Stress 1 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that brain endogenous angiotensin II is likely to be involved in central nociceptive mechanisms by its antagonistic interaction with endogenous opioid system.
angiotensin II Spec (likely) Binding (interaction) of in brain associated with nociception and endogenous opioid
1) Confidence 0.36 Published 1996 Journal Life Sci. Section Abstract Doc Link 8937511 Disease Relevance 0.16 Pain Relevance 0.34
The drugs chosen were, R-phenylisopropyl-adenosine (R-PIA) with high affinity for the A1 receptor, N-ethylcarboxamide-adenosine (NECA) with almost equal affinity for the A1 and A2 receptor and 2-(2-aminoethylamino)-carbonylethylphenylethylamino-adenosin e (APEC) with high affinity for the A2 receptor.
A2 receptor Binding (affinity) of associated with adenocard
2) Confidence 0.15 Published 1992 Journal Pharmacol. Toxicol. Section Abstract Doc Link 1438021 Disease Relevance 0.24 Pain Relevance 0.66
The drugs chosen were, R-phenylisopropyl-adenosine (R-PIA) with high affinity for the A1 receptor, N-ethylcarboxamide-adenosine (NECA) with almost equal affinity for the A1 and A2 receptor and 2-(2-aminoethylamino)-carbonylethylphenylethylamino-adenosin e (APEC) with high affinity for the A2 receptor.
A2 receptor Binding (affinity) of associated with adenocard
3) Confidence 0.15 Published 1992 Journal Pharmacol. Toxicol. Section Abstract Doc Link 1438021 Disease Relevance 0.25 Pain Relevance 0.66
Wild-type mice showed place preference for the compartment previously associated with deltorphin II and this effect was not observed in MOR-deficient mice.
deltorphin II Binding (associated) of associated with opioid receptor
4) Confidence 0.13 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11135013 Disease Relevance 0.09 Pain Relevance 0.67
The effects of adenosine A1 and A2A receptor agonists and antagonists administered intraperitoneally (i.p.) and their interaction with angiotensin II (Ang II) administered intracerebroventricularly (i.c.v.) were studied in mice using the acetic acid-induced abdominal constriction test.
angiotensin II Binding (interaction) of associated with adenocard, antagonist and agonist
5) Confidence 0.11 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11900765 Disease Relevance 0 Pain Relevance 0.48
Interaction of angiotensin II and adenosine A1 and A2A receptor ligands on the writhing test in mice.
angiotensin II Binding (Interaction) of associated with adenocard
6) Confidence 0.11 Published 2002 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 11900765 Disease Relevance 0 Pain Relevance 0.62
Angiotensin II (Ang II) has been recognized as an apoptosis inducer in podocytes, but the mechanism of apoptosis induced by Ang II is unclear.
Angiotensin II Binding (recognized) of in podocytes associated with apoptosis
7) Confidence 0.07 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19546355 Disease Relevance 0.48 Pain Relevance 0.14
Since ERK is known to be one of AT1R's signaling pathways, the present data are compatible with clinical (5,7,28,29) and experimental (4) studies showing increased angiotensin II generation in the diabetic eye.
angiotensin II Binding (generation) of in eye associated with diabetes mellitus
8) Confidence 0.05 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.78 Pain Relevance 0
Vasoconstrictors include endothelin-1 (ET-1), angiotensin II (Ang II), thromboxane A2 (TXA2), and reactive oxygen species (ROS).
angiotensin II Binding (include) of
9) Confidence 0.03 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.93 Pain Relevance 0.09
After oral administration, SR147778 displaced the ex vivo [3H]-CP 55,940 binding to mouse brain membranes (ED50 = 3.8 mg/kg) with a long duration of action, whereas it did not interact with the CB2 receptor expressed in the mouse spleen.
CB2 receptor Neg (not) Binding (interact) of in spleen
10) Confidence 0.00 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15131245 Disease Relevance 0.09 Pain Relevance 0.28

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