INT98225

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 5.07
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il5) extracellular region (Il5)
Anatomy Link Frequency
macrophage 1
skin 1
eosinophils 1
Il5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 170 100.00 Very High Very High Very High
Morphine 12 100.00 Very High Very High Very High
chemokine 12 99.04 Very High Very High Very High
Inflammation 119 98.64 Very High Very High Very High
dexamethasone 13 96.48 Very High Very High Very High
opioid receptor 1 88.84 High High
fibrosis 5 67.84 Quite High
cINOD 1 59.64 Quite High
Etanercept 1 30.64 Quite Low
anesthesia 3 19.12 Low Low
Disease Link Frequency Relevance Heat
Bacterial Meningitis 6 99.08 Very High Very High Very High
INFLAMMATION 121 98.64 Very High Very High Very High
Necrosis 12 98.52 Very High Very High Very High
Cancer 12 98.40 Very High Very High Very High
Immunization 4 96.68 Very High Very High Very High
Apoptosis 95 95.60 Very High Very High Very High
Hyperplasia 10 95.52 Very High Very High Very High
Infection 120 95.36 Very High Very High Very High
Eosinophilia 26 92.20 High High
Asthma 173 91.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We further argue that eosinophilopoiesis offers unique insights of how immune and endocrine effector loops interact to control both the steady-state responses to IL-5 and the susceptibility to modulation of these responses by drugs and cytokines.
Regulation (control) of IL-5 associated with cytokine
1) Confidence 0.45 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17691935 Disease Relevance 0.45 Pain Relevance 0.30
The effect of morphine on TGF-beta, IL-5, and IL-6 mRNA expression in PPs and ileal segments was determined following oral immunization with CT.
Regulation (effect) of IL-5 associated with immunization and morphine
2) Confidence 0.22 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11564781 Disease Relevance 0.31 Pain Relevance 1.02
When either cilostazol (Group C) or sildenafil (Group E) was used alone, this did not alter IL-5 levels in the retrieved BAL fluid.
Neg (not) Regulation (alter) of IL-5
3) Confidence 0.14 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0 Pain Relevance 0.11
The concentrations of IL-4, IL-5, IL-10, and IL-13 (R & D system, Minneapolis, MN, USA) in the BALF were measured using enzyme-linked immunosorbent assay (ELISA) kits, according to the manufacturer's instructions.


Regulation (concentrations) of IL-5
4) Confidence 0.09 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 0 Pain Relevance 0
and IL-2 responses, and 19, 20, and 21 caused IL-10, IL-4 and IL-5 responses by HTLs isolated from Pneumococci-exposed mice.


Regulation (responses) of IL-5 associated with bacterial meningitis
5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.39 Pain Relevance 0.04
, with no significant differences in IL-4 and IL-5 production [41].
Neg (no) Regulation (differences) of IL-5
6) Confidence 0.06 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 1.00 Pain Relevance 0.12
Therefore, IL-5 is an interesting target for experimental therapy in this inflammatory disorder of the skin.
Regulation (target) of IL-5 in skin associated with inflammation
7) Confidence 0.05 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 1.45 Pain Relevance 0.18
Besides its affects on differentiating B cells IL-5 predominantly works on eosinophils by effecting their differentiation, recruitment, activation, and survival in the periphery predisposing this cytokine as a central factor in regulating airway eosinophilia in asthma [7].
Regulation (affects) of IL-5 in eosinophils associated with asthma, eosinophilia and cytokine
8) Confidence 0.05 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.67 Pain Relevance 0.21
Modulation of cytokines (Interleukin (IL)-1 Beta, IL-4, IL-5, IL-6, IL-10, Interferon-gamma, IL-12, Tumor Necrosis Factor-alpha and Granulocyte macrophage colony-stimulating factor (GM-CSF)) in cervical cells and PBMCs upon stimulation with IncB and IncC was determined by real-time reverse-transcriptase (RT)-PCR and ELISA.
Spec (determined) Regulation (Modulation) of IL-5 in macrophage associated with necrosis, cancer and cytokine
9) Confidence 0.02 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2695819 Disease Relevance 0.79 Pain Relevance 0.08

General Comments

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