INT98226

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.99
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd79a)
Anatomy Link Frequency
lymphoid tissue 2
Cd79a (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 36 99.98 Very High Very High Very High
opioid receptor 3 95.12 Very High Very High Very High
cytokine 16 7.36 Low Low
Inflammation 10 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunodeficiency 2 99.80 Very High Very High Very High
Hypersensitivity 17 98.36 Very High Very High Very High
Deficiency Diseases 2 95.76 Very High Very High Very High
Immunization 32 94.40 High High
Ebola Virus Infection 55 91.20 High High
Skin Allergy 1 88.44 High High
Sinusitis 1 87.68 High High
Syndrome 25 87.04 High High
Mycoses 1 86.52 High High
Disease 22 85.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine also inhibited CT-specific IgA and IgG levels in serum.
Negative_regulation (inhibited) of IgA associated with morphine
1) Confidence 0.49 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11564781 Disease Relevance 0.31 Pain Relevance 1.03
These results indicate that morphine inhibits Ag-specific IgA responses in gut-associated lymphoid tissue at least partially through the inhibition of TGF-beta, a putative IgA switch factor, in the gastrointestinal tract.
Negative_regulation (inhibition) of IgA in lymphoid tissue associated with morphine
2) Confidence 0.35 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11564781 Disease Relevance 0.28 Pain Relevance 0.80
These results indicate that morphine inhibits Ag-specific IgA responses in gut-associated lymphoid tissue at least partially through the inhibition of TGF-beta, a putative IgA switch factor, in the gastrointestinal tract.
Negative_regulation (inhibits) of IgA in lymphoid tissue associated with morphine
3) Confidence 0.35 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11564781 Disease Relevance 0.29 Pain Relevance 0.83
IgA levels, however, were also reduced by 25% in mice with pre-existing immunity to Ad5.


Negative_regulation (reduced) of IgA
4) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2569416 Disease Relevance 0.58 Pain Relevance 0
These include selective IgA deficiency and Common Variable Immunodeficiency.
Negative_regulation (deficiency) of IgA associated with immunodeficiency
5) Confidence 0.03 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 2.53 Pain Relevance 0

General Comments

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