INT98251

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Context Info
Confidence 0.37
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 16.03
Pain Relevance 4.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12A) extracellular region (IL12A) cytoplasm (IL12A)
Anatomy Link Frequency
T cells 4
plaque 1
lung 1
IL12A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 270 100.00 Very High Very High Very High
spinal inflammation 3 99.76 Very High Very High Very High
Inflammation 221 99.26 Very High Very High Very High
Pain 21 98.44 Very High Very High Very High
psoriasis 123 95.64 Very High Very High Very High
endometriosis 168 95.12 Very High Very High Very High
rheumatoid arthritis 111 91.96 High High
Arthritis 60 91.52 High High
Inflammatory response 15 88.24 High High
beta blocker 1 86.48 High High
Disease Link Frequency Relevance Heat
Low Back Pain 3 99.76 Very High Very High Very High
Disease 248 99.56 Very High Very High Very High
Adenocarcinoma 234 99.46 Very High Very High Very High
Endometriosis 224 99.44 Very High Very High Very High
Rupture 9 99.40 Very High Very High Very High
INFLAMMATION 227 99.26 Very High Very High Very High
Cancer 419 98.64 Very High Very High Very High
Injury 18 98.56 Very High Very High Very High
Inflammatory Bowel Disease 95 97.48 Very High Very High Very High
Autoimmune Disease 15 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Negligible adjuvant effect for antibody responses and frequent adverse events associated with IL-12 treatment in humans vaccinated with pneumococcal polysaccharide.
IL-12 Binding (associated) of associated with pain
1) Confidence 0.37 Published 2001 Journal Vaccine Section Title Doc Link 11567761 Disease Relevance 0 Pain Relevance 0.10
To date the IL12A gene has not been associated with ankylosing spondylitis.
IL12A Binding (associated) of associated with spinal inflammation
2) Confidence 0.36 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3002762 Disease Relevance 1.21 Pain Relevance 0.46
Within 1 month of injury, low interferon-gamma (IFN-gamma)-positive T cells (Th1) were found in association with low interleukin-12 (IL-12) and absent IFN-gamma cytokine levels in the serum.
interleukin-12 Binding (association) of in T cells associated with injury and cytokine
3) Confidence 0.27 Published 2006 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 16542140 Disease Relevance 1.64 Pain Relevance 0.32
Within 1 month of injury, low interferon-gamma (IFN-gamma)-positive T cells (Th1) were found in association with low interleukin-12 (IL-12) and absent IFN-gamma cytokine levels in the serum.
IL-12 Binding (association) of in T cells associated with injury and cytokine
4) Confidence 0.27 Published 2006 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 16542140 Disease Relevance 1.65 Pain Relevance 0.32
In addition, we have already demonstrated the presence of IL-12 as a contributory factor in inducing the IFN-?
IL-12 Binding (presence) of
5) Confidence 0.25 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.84 Pain Relevance 0.50
Furthermore, IL-18 acts in synergy with IL-12 to promote the development of T helper 1 responses.55 Recently, increased IL-18 expression has been reported in human atherosclerotic plaque, mediating INF-?
IL-12 Binding (synergy) of in plaque associated with atherosclerotic plaque
6) Confidence 0.13 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.03 Pain Relevance 0.31
Yet, embracing the complexity that constitutes the human immune milieu, the recognition of IL-12 and IL-23 in orchestrating the development of TH1 and TH17 subsets, respectively, pose new questions in T-cell decision making [reviewed in (84)].
IL-12 Binding (recognition) of in T-cell
7) Confidence 0.12 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 0.37 Pain Relevance 0.08
In principle, IL-12 might be administered to lung adenocarcinoma patients (selected on the ground of IL-12R?
IL-12R Binding (ground) of in lung associated with adenocarcinoma
8) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702099 Disease Relevance 0.93 Pain Relevance 0.17
Six primary ADC cell suspensions selected on the ground of high level IL-12R?
IL-12R Binding (ground) of associated with adenocarcinoma
9) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702099 Disease Relevance 1.07 Pain Relevance 0.03
We first investigated IL-12R?
IL-12R Binding (investigated) of
10) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702099 Disease Relevance 1.00 Pain Relevance 0.10
These experiments demonstrated unambiguously that the IL-12R expressed by primary ADC cells was functional since their incubation with IL-12 strongly damped angiogenic activity while unaffecting cell proliferation or survival.
IL-12 Binding (incubation) of associated with adenocarcinoma
11) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702099 Disease Relevance 1.00 Pain Relevance 0
, IL-12, or IL-21, that foster commitment to Th1 or Th17 subsets, enhance IL-4+TGF-?
IL-12 Binding (commitment) of
12) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.05 Pain Relevance 0.05
It is suggested that certain genetic alteration of the IL-23 (p40 and p19) or IL-12 (p40 and p35) subunits as well as the IL-23 receptor or its ligand will lead to enhanced IL-23 production and subsequent psoriasis susceptibility.
p35 Binding (alteration) of associated with psoriasis
13) Confidence 0.07 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.02 Pain Relevance 0.51
As IL-9 is a pro-inflammatory cytokine, we then hypothesized that cytokines IL-12, IL-1?
IL-12 Binding (cytokines) of associated with inflammation and cytokine
14) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.41 Pain Relevance 0.39
IL-2 from T cells and IL-12 from mature LCs also bind to their receptors on the activated T cells.
IL-12 Binding (bind) of in T cells
15) Confidence 0.06 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 0.09 Pain Relevance 0.12
In addition, studies using the humanized anti-IL-2 receptor antibody daclizumab showed this agent to be ineffective as a treatment for ulcerative colitis.82 Early studies with anti-IL-12 antibody appear to demonstrate some activity in active CrohnÂ’s disease.83 This agent, which binds to epitopes in the p40 subunit of IL-12, may also bind to the same subunit as a component of the heterodimeric proinflammatory cytokine IL-23.
IL-12 Binding (binds) of associated with inflammatory bowel disease, disease and cytokine
16) Confidence 0.05 Published 2007 Journal J Gastroenterol Section Body Doc Link PMC2780674 Disease Relevance 0.94 Pain Relevance 0.18
IL-12 is associated with the cell-mediated immune response.
IL-12 Binding (associated) of
17) Confidence 0.04 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 0.61 Pain Relevance 0.13
IL-12 binds to the high-affinity ?
IL-12 Binding (binds) of
18) Confidence 0.03 Published 2006 Journal J Transl Med Section Body Doc Link PMC1479838 Disease Relevance 0.82 Pain Relevance 0.10
In contrast, intraperitoneal injection of the Th1-like cytokine IL-12 also reduces endometriotic lesions in vivo [66], probably by enhancing cytotoxic activity.
IL-12 Binding (injection) of associated with endometriosis and cytokine
19) Confidence 0.03 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 1.16 Pain Relevance 0.48
This suggested that IL-12 is closely associated with schizont rupture.
IL-12 Binding (associated) of associated with rupture
20) Confidence 0.02 Published 2008 Journal Malar J Section Body Doc Link PMC2443373 Disease Relevance 0.19 Pain Relevance 0.13

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