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Context Info
Confidence 0.07
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE2A, PRKG1) signal transduction (PDE2A, PRKG1) plasma membrane (PDE2A, PRKG1)
cytoplasm (PDE2A, PRKG1) Golgi apparatus (PDE2A) endoplasmic reticulum (PDE2A)
PDE2A (Homo sapiens)
PRKG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 84.16 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 5 97.64 Very High Very High Very High
Cancer 6 90.88 High High
Colon Cancer 1 87.48 High High
INFLAMMATION 1 83.92 Quite High
Pancreatic Cancer 1 35.12 Quite Low
Suicidal Behaviour 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The secondary increase of cGMP activates protein kinase G (PKG) and induces transcription of caspase genes, resulting in apoptosis. cGMP-PDEs comprise 11 gene families.
Positive_regulation (increase) of cGMP Positive_regulation (activates) of PKG associated with apoptosis
1) Confidence 0.07 Published 2001 Journal Curr Opin Investig Drugs Section Abstract Doc Link 11569947 Disease Relevance 0.57 Pain Relevance 0.08

General Comments

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