INT98275

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Context Info
Confidence 0.17
First Reported 2001
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 3.96
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE2A) signal transduction (PDE2A) Golgi apparatus (PDE2A)
endoplasmic reticulum (PDE2A) plasma membrane (PDE2A) nucleus (PDE2A)
Anatomy Link Frequency
colon 1
PDE2A (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor antagonist 2 90.20 High High
nMDA receptor 60 88.92 High High
cINOD 3 87.44 High High
Hippocampus 54 86.68 High High
5HT 26 86.24 High High
antidepressant 2 84.00 Quite High
Glutamate 78 82.56 Quite High
amygdala 8 78.52 Quite High
agonist 3 65.68 Quite High
depression 12 58.56 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 44 99.52 Very High Very High Very High
Cancer 12 98.88 Very High Very High Very High
Apoptosis 12 97.84 Very High Very High Very High
Colon Cancer 7 96.86 Very High Very High Very High
Suicidal Behaviour 2 96.60 Very High Very High Very High
Stress 164 94.16 High High
Solid Tumor 1 93.04 High High
Pancreatic Cancer 2 88.76 High High
INFLAMMATION 7 87.24 High High
Post-traumatic Stress Disorder 176 85.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In colon cancer cells, the antineoplastic effects of exisulind have been attributed, in part, to induction of cyclic guanosine 3',5'-monophosphate (cGMP) signaling through inhibition of cGMP-specific phosphodiesterases, which elevates intracellular cGMP, and novel expression of cGMP-dependent protein kinase (PKG) Ibeta, the presumed downstream effector mediating apoptosis.
Negative_regulation (inhibition) of cGMP in colon associated with colon cancer and apoptosis
1) Confidence 0.17 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731751 Disease Relevance 0.75 Pain Relevance 0.12
Cell biological studies provided circumstantial evidence that the mechanism by which these agents exert their antitumor effect should be attributed to inhibition of cyclic-GMP phosphodiesterase (cGMP-PDE).
Negative_regulation (inhibition) of cGMP
2) Confidence 0.05 Published 2001 Journal Curr Opin Investig Drugs Section Abstract Doc Link 11569947 Disease Relevance 0.56 Pain Relevance 0.09
By specifically inhibiting the action of this particular cGMP-PDE, SAANDs enable various tumor cells to process an apoptotic signal and to commit suicide without affecting normal cells.
Negative_regulation (inhibiting) of cGMP associated with suicidal behaviour, cancer and apoptosis
3) Confidence 0.05 Published 2001 Journal Curr Opin Investig Drugs Section Abstract Doc Link 11569947 Disease Relevance 0.92 Pain Relevance 0
It is in this context noteworthy that several in vitro studies have shown that activation of postsynaptic 5-HT2A/2C receptors decrease cGMP levels generated in response to NMDA administration (Marcoli et al 1997; Maura et al 2000).
Negative_regulation (decrease) of cGMP
4) Confidence 0.01 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.71 Pain Relevance 0.35
Moreover, inhibition of cGMP breakdown by coadministration of the cGMP-selective PDE inhibitor, sildenafil, causes anxiogenic effects in the mouse elevated plus maze (Volke, Wegener, Vasar 2003; Kurt et al 2004).
Negative_regulation (inhibition) of cGMP
5) Confidence 0.01 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 1.00 Pain Relevance 0.23

General Comments

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