INT98283

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.26
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (STON1)
Anatomy Link Frequency
STN 3
neuronal 1
STON1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2 97.84 Very High Very High Very High
gABA 4 97.44 Very High Very High Very High
lidocaine 10 96.86 Very High Very High Very High
deep brain stimulation 118 84.48 Quite High
Thalamus 62 83.76 Quite High
Calcium channel 4 77.84 Quite High
Serotonin 2 76.44 Quite High
Glutamate 2 74.72 Quite High
Opioid 2 74.28 Quite High
Cannabinoid 2 73.96 Quite High
Disease Link Frequency Relevance Heat
Disease 150 99.36 Very High Very High Very High
Tremor 30 98.04 Very High Very High Very High
Hypokinesia 14 97.72 Very High Very High Very High
Parkinson's Disease 56 82.36 Quite High
Burns 4 27.16 Quite Low
Poisoning 2 11.52 Low Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low
Convulsion 4 5.00 Very Low Very Low Very Low
Epilepsy 4 5.00 Very Low Very Low Very Low
Brain Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings also suggest that a focal block of the STN might alter the oscillatory activity of neurones located beyond the inhibited region.
Negative_regulation (block) of STN in STN
1) Confidence 0.48 Published 2001 Journal Brain Section Abstract Doc Link 11571226 Disease Relevance 0.44 Pain Relevance 0.29
A summary of in vitro studies is given, describing STN spontaneous activity as well as responses to depolarizing and hyperpolarizing inputs and high-frequency stimulation.
Negative_regulation (describing) of STN in STN
2) Confidence 0.39 Published 2008 Journal Adv Anat Embryol Cell Biol Section Abstract Doc Link 18727483 Disease Relevance 0.08 Pain Relevance 0.37
A summary of in vitro studies is given, describing STN spontaneous activity as well as responses to depolarizing and hyperpolarizing inputs and high-frequency stimulation.
Negative_regulation (describing) of STN in STN
3) Confidence 0.39 Published 2008 Journal Adv Anat Embryol Cell Biol Section Abstract Doc Link 18727495 Disease Relevance 0.08 Pain Relevance 0.37
In this study, microinjections of lidocaine (n = 4) and muscimol, a GABA(A) receptor agonist (n = 2), were performed in the STN of six patients with Parkinson's disease to determine whether the focal suppression of STN neuronal activity can lead to an improvement in tremor, bradykinesia and rigidity.
Negative_regulation (suppression) of STN in neuronal associated with tremor, gaba, agonist, hypokinesia, disease and lidocaine
4) Confidence 0.35 Published 2001 Journal Brain Section Abstract Doc Link 11571226 Disease Relevance 0.86 Pain Relevance 0.43
GPe cells inhibit each other as well as the STN.
Negative_regulation (inhibit) of STN
5) Confidence 0.11 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.41 Pain Relevance 0.07
When STN cells are inhibited, they also demonstrate an exaggerated rebound excitation (Bevan et al. 2002).
Negative_regulation (inhibited) of STN
6) Confidence 0.11 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.40 Pain Relevance 0.07

General Comments

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