INT98294

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.63
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT6) signal transduction (STAT6) nucleolus (STAT6)
nucleus (STAT6) cytoplasm (STAT6) signal transducer activity (STAT6)
Anatomy Link Frequency
egg 1
STAT6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 27 86.68 High High
Inflammation 9 81.60 Quite High
opioid receptor 2 75.00 Quite High
mu opioid receptor 1 69.76 Quite High
Opioid 1 68.32 Quite High
Endogenous opioid 1 64.72 Quite High
Morphine 1 63.68 Quite High
fibrosis 27 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 60 95.92 Very High Very High Very High
Infection 246 88.88 High High
Ascariasis 6 84.76 Quite High
Helminth Infection 66 83.92 Quite High
Hypersensitivity 27 82.32 Quite High
INFLAMMATION 9 81.60 Quite High
Attention Deficit Hyperactivity Disorder 3 63.04 Quite High
Schistosomiasis 63 5.00 Very Low Very Low Very Low
Fibrosis 24 5.00 Very Low Very Low Very Low
Disease 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found a trend (p=0.04) of association for only one polymorphism, rs324013, localized in the STAT6 gene promoter, taking into account age (p<10-3) and gender (p<10-3).
STAT6 Binding (association) of
1) Confidence 0.40 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.51 Pain Relevance 0.04
They bind STAT6 transcription factors as shown by electrophoretic mobility shift assays.
STAT6 Binding (bind) of
2) Confidence 0.31 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11572871 Disease Relevance 0 Pain Relevance 0.31
Linear regression after log transformation of egg counts confirmed a highly significant association with this STAT6 variant (p=0.001).
STAT6 Binding (association) of in egg
3) Confidence 0.31 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.90 Pain Relevance 0
Thus, binding of YY1 would inhibit the activity of STAT6, which would lead to increased IL-13 expression.
STAT6 Binding (binding) of
4) Confidence 0.30 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.22 Pain Relevance 0.04

General Comments

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